Published Year: 2022
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Industry and Technology Overview
Global 3D Protein Structure Analysis Market Industry Overview
In 2021, the global 3D protein structure analysis market was valued at $1,017.2 million, and it is expected to reach $2,676.6 million by 2032, growing at a CAGR of 9.32% during the forecast period 2022-2032. The growth in the global 3D protein structure analysis market is expected to be driven by technological advancements in equipment for protein structure analysis and by an increase in R&D expenditure to accelerate protein structure analysis.
Market Lifecycle Stage
One of the main goals of molecular biology research is to understand protein structure. Protein complex analysis involves a complete evaluation of the structure and function of proteins because proteins are found in intricate biological samples. The structure of protein complexes can be discovered using contemporary protein complex analysis methods. At present cryo-electron microscopy (EM), small angle X-Ray scattering (SAXS), nuclear magnetic resonance (NMR) spectroscopy, and X-Ray crystallography are used extensively in efforts to describe and understand molecular structures and molecular recognition mechanisms. Leading manufacturers like Bruker Corporation, JEOL Ltd., and Spectris plc provide equipment for 3D protein structure analysis according to one’s needs. These equipment can address the laboratory’s throughput needs.
Figure: Global 3D Protein Structure Analysis Market Snapshot
Source: BIS Research Analysis
Impact
• The presence of major equipment providers of 3D protein structure analysis has a major impact on the market. For instance, in April 2022, NJ Biopharmaceuticals LLC and JEOL Ltd. announced their collaboration to bring innovative drug discovery platform solutions using JEOL's 800 MHz NMR. With the help of this partnership, JEOL Ltd. aspires to grow its 3D protein structure analysis base and increase its existing product line.
• In August 2020, Thermo Fisher Scientific Inc., a global leader in providing scientific services, announced that it would facilitate access to cryo-electron microscopy (cryo-EM) by connecting pharmaceutical and biotechnology companies with contract research organizations (CROs) that provide start-up packages for this game-changing technology as a service.
Market Segmentation:
Segmentation 1: by Product
• Consumable
• Equipment
• Computational Software
Based on product, the global 3D protein structure analysis market is expected to be dominated by the consumable segment. This is due to the availability of several reagents, kits, screens, solvents, detergents, and others to be used in different technologies for 3D protein structure analysis.
Segmentation 2: by End User
• Biopharmaceutical Company
• Academic and Research Institute
• Other End User
Based on end users, the biopharmaceutical company segment is the dominating end user in the market. The expanding application of protein structure analysis in a variety of industries, primarily in pharmaceutical companies for drug development, is further expected to contribute to its growing trend.
Segmentation 3: by Region
• North America
• Europe
• Asia-Pacific
• Rest-of-the-World
North America dominated the global market with a revenue of $395.5 million in 2021. However, the Asia-Pacific (APAC) region, constituting several emerging economies, is expected to register the highest CAGR of 10.33% during the forecast period 2022-2032.
Recent Developments in Global 3D Protein Structure Analysis Market
• In February 2022, JEOL Ltd. announced the development of a new cold field emission cryo-electron microscope (cryo-EM), the CRYO ARM 200 II (JEM-Z200CA), dedicated to single particle analysis of proteins.
• In November 2021, JEOL Ltd. announced the availability of "ECZ Luminous" nuclear magnetic resonance console (JNM-ECZL series). This product is the next step in spectrometer miniaturization and extended performance through state-of-the-art digital and high-frequency technologies.
• In October 2020, Thermo Fisher Scientific Inc. introduced two ground-breaking imaging filters, i.e., the Thermo Scientific Selectris Imaging Filter and the Thermo Scientific Selectris X Imaging Filter, which elevated cryo-electron microscopy (cryo-EM) to a new level by allowing users to view proteins at true atomic resolution.
• In April 2021, Thermo Fisher Scientific Inc. unveiled the Thermo Scientific E-CFEG, a significant accessory for the Thermo Scientific Krios Cryo-TEM and the company's new cold field emission gun. In comparison to other commercially available technologies, the E-four CFEG's key components work together to achieve single particle analysis (SPA) resolution levels that are unprecedented.
Demand – Drivers and Limitations
Following are the demand drivers for the global 3D protein structure analysis market:
• Technological Advancements in Equipment for Protein Structure Analysis
• Increase in R&D Expenditure in Drug Discovery and Development
• Rising Focus on Automation and Miniaturization in X-Ray Crystallography Workflow
The market is expected to face some limitations too due to the following challenges:
• Certain Instrument Limitations Pertaining to 3D Protein Structure Analysis
• Lack of Qualified Personnel
• High Cost and Time-Consuming Method
Analyst View
According to Nitish Kumar, Principal Analyst, BIS Research, “Global 3D protein structure analysis market is a well-established market and is expected to grow further in the coming years due to the continuous technological advancements in equipment for protein structure analysis along with the increase in the use of small angle X-Ray scattering (SAXS) technique for 3D protein structure analysis."
3D Protein Structure Analysis Market - A Global and Country Analysis
Focus on Product, End User, and Region - Analysis and Forecast, 2022-2032
Some Faq's
Frequently Asked Questions
The function and structure of proteins are widely studied in proteomics, which facilitates the recognition of protein biomarkers associated with specific disease states, thereby providing potential targets for therapeutic treatment. Knowledge about the three-dimensional (3D) structure of proteins provides a high understanding of how the protein works and to use that collective data for various purposes. For instance, the information is used to control or alter protein's function, understand various protein biological interactions, and assist drug discovery.
Modern biotechnology places a significant emphasis on understanding the structure and function of proteins. Understanding 3D structures at atomic resolution helps with molecular docking, structure-based drug design, and understanding how proteins work. X-Ray crystallography, commonly known as single-crystal X-Ray diffraction, is the main method used to determine the 3D structure of proteins at atomic resolution. While most developing countries still rely on X-Ray crystallography to analyze the structure of proteins, developed nations like the U.S., Germany, and the U.K. have established their footprint on other technologies, most notably relying upon cryo-electron microscopy and NMR spectroscopy owing to their additional benefits.
The global 3D protein structure analysis market has seen major developments such as partnerships, collaborations, and product launches by key players operating in the market. According to BIS Research analysis, most of the companies preferred partnerships and collaborations as a strategy to further increase their growth in the global 3D protein structure analysis market. Companies such as JEOL Ltd., and Cambridge Isotope Laboratories, Inc. have majorly adopted the partnership and collaboration strategy.
A new entrant can focus on developing efficient and accurate automating strategies which have not been used before. Novel ideas include the increase in the use of small angle X-Ray scattering (SAXS) technique for 3D protein structure analysis in the global 3D protein structure analysis market.
The following can be considered the USPs of the report:
· Extensive competitive benchmarking of the top 15 players done to offer a holistic view of the global 3D protein structure analysis market landscape
· Market ranking analysis based on product portfolio, recent developments, and regional spread
· Coverage of investment landscape, including product adoption scenario, funding, and patent analysis
This report will be useful for manufacturers looking to start producing equipment, consumables, and computational software for 3D protein structure analysis. Additionally, the report would be useful for manufacturers already producing these systems and equipment.
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