Published Year: 2022
NGS Sample Preparation Market - A Global and Regional Analysis: Focus on Product, Workflow, Therapeu
The global NGS sample preparation market is projected to reach $3,279.3 million by 2026,...
Market Research Report
A quick peek into the report
Industry and Technology Overview
Global Library Preparation Automation Market Industry Overview
In 2021, the global NGS library preparation automation market was valued at $1,273.2 million, and it is expected to reach $3,803.3 million by 2029, growing at a CAGR of 14.85% during the forecast period 2022-2029. The growth in the global NGS library preparation automation market is expected to be driven by increasing demand for next-generation sequencing, as there is no human error when the system is fully automated. Additionally, it saves time and money.
Market Lifecycle Stage
Automated NGS library preparation methods can address the issue like chances of human error during library preparation, as they require low amounts of hands-on time, thereby lowering manual error risk. Fully automated NGS library preparation solutions provide good library preparation quality, and at the same time, transform the efficiency of the workflow. Thus, NGS library preparation automation is extremely beneficial as it helps increase the lab’s efficiency and generates more consistent results. Automation can help one maintain turnaround time and expand sample workload. Leading automation companies like Agilent Technologies, Inc., Hamilton Company, and Tecan Trading AG provide various methods for adopting NGS library preparation automation according to one’s needs. These fully automated instruments can address the laboratory’s throughput needs.
Figure: Global NGS Library Preparation Automation Market Snapshot
Source: BIS Research Analysis
Impact
• The presence of major instrument providers of NGS library preparation automation has a major impact on the market. For instance, in March 2021, Integrated DNA Technologies, Inc., a subsidiary of Danaher., acquired Swift Biosciences. Swift Biosciences is the pioneer in NGS library preparation genomics kit development for academic, translational, and clinical research. With the help of this acquisition, Integrated DNA Technologies, Inc. aspires to grow its library preparation automation base and increase its existing product line.
• Companies such as Agilent Technologies, Inc. partnered with Element Biosciences Inc. in February 2022 and developed new and disruptive DNA sequencing platforms through this partnership. Element Biosciences Inc.’s AVITI System was integrated with Agilent Technologies Inc.’s SureSelect target enrichment panels, through which this technology can be accessed by a larger number of customers. SureSelect is a DNA library Preparation Automation kit launched by Agilent Technologies, Inc. in 2013.
Impact of COVID-19
In March 2019, the world was hit by the Sars-CoV-2 virus, which led to the entire world shut down and everybody getting tested for the virus. As the amount of testing increased, it became important to increase the pace of testing as well. To do this, automated library preparation systems were set up at many clinical and diagnostic centers to decrease hands-on time and increase the pace of testing.
Steps performed in this process include extracting RNA sample from the patients, which is then reverse transcribed to cDNA, and then amplified using PCR. However, before the PCR step, a sample library needs to be prepared, which is the most time-consuming step of the entire process. With the help of instruments like the Hamilton NGS STAR 96, the entire NGS library preparation automation protocol can be performed hands-free on the instrument itself. Therefore, with the emergence of COVID-19, the popularity of NGS library preparation automation systems has increased.
Market Segmentation:
Segmentation 1: by Sequencing Type
• DNA Sequencing
• RNA Sequencing
The global NGS library preparation automation market in the sequencing segment is expected to be dominated by DNA sequencing technology. This is due to the expansion of therapeutic and diagnostic uses for DNA sequencing as well as the decreasing cost of genomic sequencing globally.
Segmentation 2: by Product
• Library Preparation Automated Kits and Consumables
• Automated Instruments
The global NGS library preparation automation market is dominated by library preparation automated kits and consumables. This is owing to the availability of several library preparation kit types, falling sequencing costs, expanding use of NGS in a variety of industries, including drug development, diagnostics, and animal research, as well as the availability of research grants.
Segmentation 3: by Application
• Research
• Diagnostics
The research application dominated the market. The growth of the research segment is primarily attributed to the identification of novel oncology targets, a growing understanding of cancer, and the expanding demand for the development of novel therapeutic approaches in oncology.
Segmentation 4: by End User
• Pharmaceutical and Biotechnology Companies
• Clinical and Diagnostic Laboratories
• Academic and Research Institutions
• Other End Users (Reference laboratories, Sequencing Laboratories, and Others)
Academic and research institutions dominated the end user segment in the market. The growth of this segment is primarily attributed to the growth in financing for genomic R&D and the persistent rise in demand for affordable NGS tools and supplies.
Segmentation 5: by Region
• North America
• Europe
• Asia-Pacific
• Latin America
• Rest-of-the-World
In 2021, the North America region dominated the global market, and it is expected to hold its dominance throughout the forecast period 2022-2029. However, the Asia-Pacific (APAC) region, constituting several emerging economies, is expected to register the highest CAGR of 15.87% during the forecast period 2022-2029.
Recent Developments in Global NGS Library Preparation Automation Market
• In March 2022, Beckman Coulter, Inc. launched CellMekSPS, which is a fully automated sample preparation system that is used for clinical flow cytometry. This fully automated system offers an on-demand multitude of sample types processing that can help laboratories expand testing capabilities.
• In June 2022, Bio-Rad Laboratories, Inc. launched its SEQuoia Express Stranded RNA Library Prep Kit at the AGBT 2022. This kit is highly efficient for optimal RNA Sequencing Library Preparation and can be used for comprehensive transcriptome profiling.
• In April 2022, OPENTRONS launched four new OT-2 workstations for all types of applications, including NGS, PCR, and protein purification. Its NGS workstation automates multiple steps of the pre-sequencing, including library preparations. This expansion is expected to increase the accessibility of automation products to customers.
• In June 2022, PerkinElmer, Inc. launched its BioQule NGS System, which was an automated NGS solution for library preparation for up to eight samples. BioQule NGS System enabled researchers to produce high-quality NGS libraries through its optical quantification and robust liquid handling technology.
Demand – Drivers and Limitations
Following are the demand drivers for the global NGS library preparation automation market:
• Rising Demand for Next-Generation Sequencing (NGS)
• Fully Automated Systems Help in Avoiding Human Error
• Automated Instruments Can Save Money
• Library Preparation is the Most Time-Consuming Step and Automation is Promising a Significant Reduction in Time
The market is expected to face some limitations too due to the following challenges:
• Complex Handling of NGS Library Preparation Automation Systems
• High Initial Cost of NGS Library Preparation Automation Instruments
Analyst’s View
According to Nitish Kumar, Principal Analyst, BIS Research, “Global NGS library preparation automation market is a well-established market and is expected to grow further in the coming years due to the continuous increase in the demand for NGS, as there is no human error when the system is automated. Additionally, such an automated system saves time and money."
NGS Library Preparation Automation Market - A Global and Regional Analysis
Focus on Sequencing Type, Product, Application, End User, and Region - Analysis and Forecast, 2022-2029
Some Faq's
Frequently Asked Questions
Automation of the library preparation step in the NGS workflow is known as NGS library preparation automation. This is the second step of the entire workflow right after nucleic acid extraction, up to the preparation of sequencing reads right before sequencing. Library preparation is the most time-consuming and error-prone step in the entire NGS workflow, thereby increasing the demand for its automation.
The adoption of next-generation sequencing has increased significantly and has since become a valuable tool in many diseases’ diagnoses. Converting a native DNA into a barcoded library is a highly technical process, which requires significant time and reagents. Additionally, they are error-prone, and a single hurdle can lead to the corruption of entire testing results. Thus, some companies have to outsource their NGS testing process. However, with the help of dedicated automation solutions, such as liquid handling instruments or integrated microfluidic systems, this can be solved. These automated NGS library prep systems can save overall time and cost and reduce errors.
The global NGS library preparation automation market has seen major developments such as business expansion, partnership, collaboration, and joint ventures by key players operating in the market. According to BIS Research analysis, the majority of the companies preferred partnerships, collaborations, and joint ventures as a strategy to further increase their growth in the global NGS library preparation automation market. Companies such as Agilent Technologies, Inc., F. Hoffman-La Roche Ltd, Hamilton Company., and Illumina, Inc. have majorly adopted partnerships, collaborations, and joint venture strategies.
A new entrant can focus on developing efficient and accurate automating strategies which have not been used before. Novel ideas include the entrance of single-cell and spatial multi-omics companies into the global NGS library preparation automation market.
The following can be considered the USPs of the report:
· Extensive competitive benchmarking of the top 20 players been done to offer a holistic view of the global NGS library preparation automation market landscape
· Market ranking analysis based on product portfolio, recent developments, and regional spread
· Coverage of investment landscape, including product adoption scenario, funding, and patent analysis
This report will be useful for manufacturers who are looking to start producing automated NGS library preparation instruments or kits. Additionally, the report would be useful for manufacturers who are already producing these systems and instruments.
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