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US MRD Testing Facilities Set for Steady Growth Over the Next 10 Years

18 Mar 2025


Minimal Residual Disease (MRD) testing is crucial for tracking leukemia and lymphoma, helping detect cancer recurrence with high precision. Many U.S. laboratories and medical institutions offer MRD testing services, making it an essential component of oncology diagnostics and treatment monitoring. Advanced technologies like Next-Generation Sequencing (NGS), digital PCR, and flow cytometry have enhanced MRD detection, improving sensitivity and early intervention. As MRD testing continues to evolve, its role in precision medicine and cancer management is expanding, driving widespread adoption in clinical settings.

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U.S. MRD Testing Facilities Market Overview

According to BIS research U.S. Minimal Residual Disease (MRD) testing market is projected to reach $1,667.5 million by 2030, growing at a CAGR of 14.18% (2024-2030). In 2023, U.S. testing facilities held a 39.53% share of the global MRD testing market, reflecting strong demand for high-precision cancer monitoring. Numerous U.S. laboratories provide MRD testing, with factors such as technology used, test accuracy, and clinical expertise influencing patient choices. The rising adoption of Next-Generation Sequencing (NGS), digital PCR, and flow cytometry continues to drive market growth, making MRD testing a key component of precision oncology.

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U.S. MRD Testing Facilities Market Dynamics: Growth Drivers, Technology Landscape & Challenges

Market Drivers

  • Rising Cancer Incidence: In 2022, leukemia accounted for 13% of adolescent cancer diagnoses, while myeloma cases exceeded 34,000 (American Cancer Society).
  • Personalized Medicine Demand: Increasing use of MRD testing in oncology services enhances treatment precision and patient outcomes.
  • Expanding Market Segments:
    • Hospitals & Specialty Clinics: Held 44.01% market share in 2023, integrating MRD for advanced cancer care.
    • Research Institutions & Diagnostic Labs: Projected to grow at 14.1% and 13.3% CAGR, respectively, highlighting MRD’s role in clinical trials.

Technology Landscape

  • Next-Generation Sequencing (NGS): Offers high sensitivity and accuracy, becoming a gold standard in MRD detection.
  • Digital PCR: Provides precise quantification of residual cancer cells, improving early relapse detection.
  • Flow Cytometry: A widely used method in MRD testing, enabling real-time cell analysis for leukemia and lymphoma monitoring.

Market Challenges

  • High Testing Costs: Advanced MRD technologies require significant investment, limiting accessibility in some healthcare settings.
  • Standardization Issues: Variability in testing methodologies affects result consistency and clinical decision-making.
  • Regulatory Hurdles: Strict FDA and CLIA compliance requirements slow down new MRD testing approvals and adoption

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Conclusion

The growing adoption of advanced technologies is transforming MRD testing, enhancing accuracy, accessibility, and personalized cancer treatment. By leveraging in-depth genetic data, MRD testing is shaping precision medicine in oncology.

The U.S. MRD testing market is driven by innovation, strategic collaborations, and personalized medicine advancements. While cost barriers and sensitivity challenges remain, progress in companion diagnostics, Medicare coverage, and clinical trials is expanding accessibility. By overcoming these hurdles, MRD testing is poised to revolutionize cancer care and patient outcomes in the coming years.