Global Human Microbiome Modulators Market

Global Human Microbiome Modulators Market: Focus on Non-Dairy Supplements, Drugs, Applications, 15 Countries Data, Pipeline Product Mapping, and Competitive Landscape – Analysis and Forecast, 2018-2023

The global human microbiome modulators market has been witnessing a steady annual growth rate of approximately 6.08% in past three years (2015-2017), and the market is expected to continue to grow with a double digit CAGR of 16.29% during the forecast period, 2018-2023.

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Published Year: 2018
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In the era of precision medicine, the healthcare industry is focused on the development of advanced therapeutics to deliver improved patient care and enhance treatment outcome. The increasing prevalence of chronic disorders and an overall increased demand for preventive medication with minimal/no side-effect are promoting the growth of the human microbiome modulators market. Thereby, the advent of precision medicine approach and development of individualized care regimes are improving quality of life of the patients and reducing economic, societal, and clinical burden.

Presently, product categories within the human microbiome modulators market include probiotics and creams, prebiotics and dietary supplements, and drugs. Till date, the healthcare industry has witnessed a number of successful products modulating the gut microbiome, addressing digestive health. However, successful research substantiating a more inclusive role of the microbiome in human health and diseases, including immune health, women’s health, oral health, and other health applications such as skin health, have further drawn the attention of several pharmaceutical companies to venture into this lucrative market by either advancing their respective product portfolios or acquiring companies with immense potentials. Further, several players are now focusing on the development of drugs modulating the microbiome, which is anticipated to enhance the growth of the entire market.

The purpose of the study is to gain a holistic view of the global human microbiome modulators market in terms of various factors influencing the market, including regulatory reforms and technological advancements. The market has been segmented into ‘products’, ‘applications’, and ‘regions’. The scope of this report is centered upon conducting a detailed study of the products allied with the human microbiome modulators market. In addition, the study also includes the exhaustive information on the unmet needs, perception on the new products, competitive landscape (including pipeline analysis), market share of leading manufacturers, growth potential of each product, application, and region, as well as other vital information with respect to human microbiome modulators market. The report presents the reader with an opportunity to unlock comprehensive insights with respect to the market and helps in forming well-informed strategic decisions. The research uncovers some of the substantial parameters that must be taken into consideration before entering into the market.

This research report aims at answering various aspects of the global human microbiome modulators market with the help of the key factors driving the market, the restraints, and the current growth opportunities that are going to shape the future trajectory of the market expansion. The report includes an in-depth examination of the key players and recent developments taking place in this market. Moreover, the report includes chapters on market dynamics (market drivers, opportunities, and challenges) and industry analysis as well.

The research study highlights the factors governing the industry attractiveness with Porter’s Five Forces for a comprehensive understanding of the global human microbiome modulators market. Moreover, the study includes detailed product mapping, market estimation, and analysis of key trends in multiple geographical regions, growth of human microbiome modulators market in each region for different applications, and the key strategies and developments by the prominent human microbiome modulators manufacturers.

The answers to the following key questions can be derived from this report:

•    What are the major market drivers, challenges, and opportunities in the global human microbiome modulators market?
•    What are the underlying structures resulting in the emerging trends within the human microbiome modulators industry?
•    What was the market value of the leading segments and sub-segments of the global human microbiome modulators market in 2017?
•    How will each segment of the global human microbiome modulators market grow during the forecast period and what will be the revenue generated by each of the segments by the end of 2023?
•    What are the influencing factors that may affect the market share of the key players?
•    How will the industry evolve during the forecast period, 2018- 2023?
•    What are the key developmental strategies which are being implemented by the key players in order to sustain in the competitive market?
•    What are the key product types in human microbiome modulators market? What are the major benefits of each product type?
•    How has the market been segmented on the basis of application? Which application is dominating the global human microbiome modulators market and its reason? 
•    Who are the key manufacturers in human microbiome modulators market and what are their contributions?
•    What is the status of each major human microbiome modulators manufacturer with respect to their pipeline?
•    What is the scope of each human microbiome modulators product in North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World?
•    What are the key regulatory implications in developed and developing regions for human microbiome modulators?
•    What is the growth potential of human microbiome modulators in each region, including North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World?
•    Which human microbiome modulators product type is having most promising growth and in which application type?

The key manufacturers who have been contributing significantly to the human microbiome modulators market include Sanofi S.A., The Procter and Gamble Company, Bayer AG, Koninklijke DSM N.V., E. I. du Pont de Nemours and Company, Yakult Honsha Co., Ltd., BioGaia AB, Probi AB, Chr. Hansen Holding A/S, Ingredion Incorporated, and Immuron Ltd., among others.

    Executive Summary
    1    Market Overview
          1.1    Classification of Human Microbiome Modulators
          1.2    Historical Perspective of Human Microbiome Modulators
          1.3    The Human Microbiome Project (2007-2016)
          1.4    Impact of Microbiome on Human Physiology
          1.5    Global Footprint
          1.6    Human Microbiome Modulators: Future Potential
 
    2    Market Dynamics
          2.1    Overview
          2.2    Iceberg Analysis
          2.3    Market Drivers
                   2.3.1    Rising Geriatric Population
                   2.3.2    Increasing Incidence of Lifestyle-related Diseases
                   2.3.3    Gradual Demand for Preventive Medication with Minimal/No Side-Effects
                   2.3.4    Limited Success Rate of Drugs Targeting Specific Diseases
          2.4    Market Restraints
                   2.4.1    Insufficient Application-Based Research Hindering Market Pull
                   2.4.2    Lack of Awareness Regarding the Usage of Probiotics and Prebiotics
                   2.4.3    Non-Harmonized Government Regulations on Probiotics and Prebiotics
          2.5    Market Opportunities
                   2.5.1    Massive Scope for Phenomenal Profits through Venturous Investments
                   2.5.2    Integrative Industry-Academia Collaboration
                   2.5.3    Rise of Next-Generation Probiotics
                   2.5.4    Novel Diagnostic Applications
 
    3    Competitive Landscape
          3.1    Key Strategies and Developments
                   3.1.1    Joint Ventures, Collaborations, and Partnerships
                   3.1.2    Fundings and Business Expansion Activities
                   3.1.3    Product Launch
                   3.1.4    Mergers and Acquisitions
                   3.1.5    Product Approvals
          3.2    Market Share Analysis
          3.3    Growth Share Analysis
                   3.3.1    Growth Share Analysis (by Application)
                   3.3.2    Growth Share Analysis (by Company)
                   3.3.3    Growth Share Analysis (by Country)
          3.4    Industry Attractiveness
                   3.4.1    Bargaining Power of Suppliers
                   3.4.2    Bargaining Power of Buyer
                   3.4.3    Threat of New Entrants
                   3.4.4    Threat of Substitute Products
                   3.4.5    Intensity of Competitive Rivalry
          3.5    Product Pipeline Analysis
 
    4    Regulatory Framework
          4.1    Legal Requirements and Framework in the U.S.
                   4.1.1    For Probiotics
                   4.1.2    For Prebiotics/Dietary Fibers
                   4.1.3    For Live Biotherapeutic Products (LBPs)
          4.2    Legal Requirements and Framework in Europe
          4.3    Legal Requirements and Framework in Asia-Pacific
                   4.3.1    Japan
                   4.3.2    China
          4.4    Global Microbiome Consortiums
 
    5    Global Human Microbiome Modulators Market (by Product)
          5.1    Overview
          5.2    Probiotics and Creams
          5.3    Prebiotics and Dietary Supplements
          5.4    Drugs
 
    6    Global Human Microbiome Modulators Market (by Application)
          6.1    Overview
          6.2    Digestive Health
          6.3    Immune Health
          6.4    Women’s Health
          6.5    Oral Health
          6.6    Others
 
    7    Global Human Microbiome Modulators Market (by Region)
          7.1    Analysis of Growth Potential of Different Countries: Global Human Microbiome Modulators Market
          7.2    North America
                   7.2.1    The U.S.
                   7.2.2    Canada
          7.3    Europe
                   7.3.1    Italy
                   7.3.2    Russia
                   7.3.3    France
                   7.3.4    Poland
                   7.3.5    Germany
                   7.3.6    The U.K.
                   7.3.7    Rest-of-Europe
          7.4    Asia-Pacific
                   7.4.1    Japan
                   7.4.2    Australia
                   7.4.3    South Korea
                   7.4.4    China
                   7.4.5    India
                   7.4.6    Rest-of-Asia-Pacific
          7.5    Latin America
                   7.5.1    Brazil
                   7.5.2    Mexico
                   7.5.3    Rest-of-Latin America
          7.6    Rest-of-the-World
 
    8    Company Profiles
          8.1    Overview
          8.2    Bayer AG
                   8.2.1    Company Overview
                   8.2.2    Role of Bayer AG in the Human Microbiome Modulators Market
                   8.2.3    Financials
                   8.2.4    Key Insights about Financial Health of the Company
                   8.2.5    Global Presence
                   8.2.6    SWOT Analysis
          8.3    BioGaia AB
                   8.3.1    Company Overview
                   8.3.2    Role of BioGaia AB in the Human Microbiome Modulators Market
                   8.3.3    Financials
                   8.3.4    Key Insights about Financial Health of the Company
                   8.3.5    Global Presence
                   8.3.6    SWOT Analysis
          8.4    Chr. Hansen Holding A/S
                   8.4.1    Company Overview
                   8.4.2    Role of Chr. Hansen Holding A/S in the Human Microbiome Modulators Market
                   8.4.3    Financials
                   8.4.4    Key Insights about Financial Health of the Company
                   8.4.5    Global Presence
                   8.4.6    SWOT Analysis
          8.5    DowDuPont Inc.
                   8.5.1    Company Overview
                   8.5.2    Role of DowDuPont Inc. in the Human Microbiome Modulators Market
                   8.5.3    Financials
                   8.5.4    Key Insights about Financial Health of the Company
                   8.5.5    Global Presence
                   8.5.6    SWOT Analysis
          8.6    Garden of Life, LLC.
                   8.6.1    Company Overview
                   8.6.2    Role of Garden of Life, LLC. in Human Microbiome Modulators Market
                   8.6.3    SWOT Analysis
          8.7    Ingredion Incorporated
                   8.7.1    Company Overview
                   8.7.2    Role of Ingredion Incorporated in Human Microbiome Modulators Market
                   8.7.3    Financials
                   8.7.4    Key Insights about Financial Health of the Company
                   8.7.5    Global Presence
                   8.7.6    SWOT Analysis
          8.8    ISOThrive LLC
                   8.8.1    Company Overview
                   8.8.2    Role of ISOThrive LLC in the Human Microbiome Modulators Market
                   8.8.3    SWOT Analysis
          8.9    Jarrow Formulas, Inc.
                   8.9.1    Company Overview
                   8.9.2    Role of Jarrow Formulas, Inc. in Human Microbiome Modulators Market
                   8.9.3    SWOT Analysis
         8.10   Koninklijke DSM N.V.
                   8.10.1    Company Overview
                   8.10.2    Role of Koninklijke DSM N.V. in the Human Microbiome Modulators Market
                   8.10.3    Financials
                   8.10.4    Key Insights about Financial Health of the Company
                   8.10.5    Global Presence
                   8.10.6    SWOT Analysis
         8.11   Lallemand Inc.
                   8.11.1    Company Overview
                   8.11.2    Role of Lallemand Inc. in Human Microbiome Modulators Market
                   8.11.3    SWOT Analysis
         8.12   MicroBiome Therapeutics, LLC
                   8.12.1    Company Overview
                   8.12.2    Role of MicroBiome Therapeutics, LLC in Human Microbiome Modulators Market
                   8.12.3    SWOT Analysis
         8.13   Pharmavite LLC
                   8.13.1    Company Overview
                   8.13.2    Role of Pharmavite LLC in Human Microbiome Modulators Market
                   8.13.3    SWOT Analysis
         8.14   Probi AB
                   8.14.1    Company Overview
                   8.14.2    Role of Probi AB in the Human Microbiome Modulators Market
                   8.14.3    Financials
                   8.14.4    Key Insights about Financial Health of the Company
                   8.14.5    Global Presence
                   8.14.6    SWOT Analysis
         8.15   Probiotics International Limited (ADM Protexin)
                   8.15.1    Company Overview
                   8.15.2    Role of ADM Protexin in Human Microbiome Modulators Market
                   8.15.3    SWOT Analysis
         8.16   Quorum Innovations, LLC
                   8.16.1    Company Overview
                   8.16.2    Role of Quorum Innovations, LLC in Human Microbiome Modulators Market
                   8.16.3    SWOT Analysis
         8.17   Sanofi S.A.
                   8.17.1    Company Overview
                   8.17.2    Role of Sanofi S.A. in Human Microbiome Modulators Market
                   8.17.3    Financials
                                 8.17.3.1     Key Insights about Financial Health of the Company
                   8.17.4    SWOT Analysis
         8.18   The Procter and Gamble Company
                   8.18.1    Company Overview
                   8.18.2    Role of The Procter and Gamble Company in the Human Microbiome Modulators Market
                   8.18.3    Financials
                   8.18.4    Key Insights about Financial Health of the Company
                   8.18.5    Global Presence
                   8.18.6    SWOT Analysis
         8.19   Yakult Honsha Co., Ltd.
                   8.19.1    Company Overview
                   8.19.2    Role of Yakult Honsha Co., Ltd. in Human Microbiome Modulators Market
                   8.19.3    Financials
                   8.19.4    Key Insights about Financial Health of the Company
                   8.19.5    Global Presence
                   8.19.6    SWOT Analysis
 
    9    Research Scope and Methodology
          9.1    Report Scope
          9.2    Human Microbiome Modulators Market: Research Methodology
 

List of Tables

Table 2.1    Impact Analysis of Market Drivers
Table 2.2    Impact Analysis of Market Restraints
Table 3.1    R&D Expenditure of Major Human Microbiome Therapeutic Companies (as of FY2017)
Table 4.1    Global Microbiome Consortiums and Their Participants
Table 6.1    Documented Microbial Associations with Disease Status

List of Figures

Figure 1    Antibiotic Resistance (%) in OECD Countries, 2014
Figure 2    Global Value of Precision Medicine Within Healthcare, 2016 and 2020
Figure 3    Impact Analysis of Market Drivers and Market Restraints, 2018-2023
Figure 4    Global Human Microbiome Modulators Market Snapshot
Figure 5    Dominating Segments of Global Human Microbiome Modulators Market, 2017 and 2023
Figure 6    Global Human Microbiome Modulators Market (by Products), 2017 and 2023
Figure 7    Global Human Microbiome Modulators Market (by Application), 2017 and 2023
Figure 8    Global Human Microbiome Modulator Market (by Region), 2017 and 2023
Figure 9    Pipeline Analysis
Figure 10    Vital Strategies Incorporated by Key Players in the Global Human Microbiome Modulators Market
Figure 11    Market Statistics
Figure 12    Market Share Analysis for the Global Human Microbiome Modulators Market, 2017
Figure 1.1    Classification of Human Microbiome Modulators
Figure 1.2    Evolution of Human Microbiome Modulators
Figure 1.3    Significant Milestones from the HMP (Phase 1)
Figure 1.4    Global Human Microbiome Modulators Market, 2017-2023
Figure 2.1    Iceberg Analysis
Figure 2.2    Projected Global Geriatric Population (in billion), 1900-2100
Figure 2.3    Global Deaths Per Year By Cause (WHO), 2016
Figure 2.4    Average Healthcare Expenditure (by OECD Countries), 2015
Figure 3.1    Share of Key Developments and Strategies, January 2014-August 2018
Figure 3.2    Agreement, Collaboration, and Partnership Share (by Companies), January 2014-August 2018
Figure 3.3    Funding and Expansion Activities Share (by Companies), January 2014-August 2018
Figure 3.4    Product Launches Share (by Companies), January 2014-August 2018
Figure 3.5    Merger and Acquisition Share (by Companies), January 2014-August 2018
Figure 3.6    Product Approval Share (by Companies), January 2014-August 2018
Figure 3.7    Market Share Analysis for the Global Human Micorbiome Modulators  Market, 2016
Figure 3.8    Market Share Analysis for Global Human Microbiome Modulators Market, 2017
Figure 3.9    Growth Share Matrix for Global Human Microbiome Modulators Market (by Application), 2017
Figure 3.10    Growth Share Matrix for Global Human Microbiome Modulators Market (by Company), 2017
Figure 3.11    Growth Share Matrix for Global Human Microbiome Modulators Market (by Country), 2017
Figure 3.12    Industy Attractiveness (Porter’s Five Forces Analysis)
Figure 3.13    Bargaining Power of Suppliers: Overall Impact
Figure 3.14    Bargaining Power of Buyers: Overall Impact
Figure 3.15    Threat of New Entrants: Overall Impact
Figure 3.16    Threat of Substitute Products: Overall Impact
Figure 3.17    Intensity of Competitive Rivalry: Overall Impact
Figure 3.18    Pipeline Analysis
Figure 3.19    Distribution of Pipeline Products According to Their Development Stage
Figure 4.1    Guidelines for the Evaluation of Probiotics for Food Use
Figure 4.2    Guidelines for the Chemistry, Manufacturing, and Control of LBPs by the FDA, 2016
Figure 4.3    Guidelines on the Scientific Requirements for Health Claims by the EFSA (2015)
Figure 4.4    Guidelines by the CFDA for Approval of Health Foods
Figure 5.1    Human Microbiome Modulators Market (by Product)
Figure 5.2    Global Human Microbiome Modulators Market (by Product), 2017 and 2023
Figure 5.3    Mechanism of Action of Probiotic in the Gut Microbiome
Figure 5.4    Global Human Microbiome Modulators Market (by Probiotics and Creams), 2017-2023
Figure 5.5    Effects of Prebiotics in Human Body
Figure 5.6    Global Human Microbiome Modulators Market (by Prebiotics and Dietary Supplements), 2017-2023
Figure 5.7    Mechanisms of Action of Human Microbiome Therapeutic Drugs
Figure 5.8    Number of Drugs in Active Development, 2011-2017
Figure 5.9    Global Human Microbiome Modulators Market (by Drugs), 2017-2023
Figure 6.1    Global Human Microbiome Modulators Market (by Application), 2017 and 2023
Figure 6.2    Global Human Microbiome Modulators Market (by Digestive Health), 2017-2023
Figure 6.3    Total Market Size for Digestive Health-related Modulators  (2017-2023)
Figure 6.4    Interdepending Regulators of the Immune System
Figure 6.5    Global Human Microbiome Modulators Market (by Immune Health), 2017-2023
Figure 6.6    Total Market Size for Immune Health-related Modulators  (2017-2023)
Figure 6.7    Inter-related Factors Governing Women’s Health
Figure 6.8    Global Human Microbiome Modulators Market (by Women’s Health), 2017-2023
Figure 6.9    Total Market Size for Women’s Health-related Modulators  (2017-2023)
Figure 6.10    Ecological Shifts in the Oral Microbiome Causing a Diseased Oral Cavity
Figure 6.11    Global Human Microbiome Modulators Market (by Oral Health), 2017-2023
Figure 6.12    Total Market Size for Oral Health-related Modulators  (2017-2023)
Figure 6.13    Global Human Microbiome Modulators Market (by Other Health Applications), 2017-2023
Figure 6.14    Total Market Size for Other Health-related Modulators, 2017-2023
Figure 7.1    Global Human Microbiome Modulators Market Scenario, 2017 and 2023
Figure 7.2    Global Human Microbiome Modulators (by Region), 2017-2023
Figure 7.3    Analysis of Growth Potential (by Countries)
Figure 7.4    North America: Human Microbiome Modulators Market, 2017-2023
Figure 7.5    North America: Market Dynamics
Figure 7.6    North America: Human Microbiome Modulators Market (by Country), 2017 and 2023
Figure 7.7    The U.S: Human Microbiome Modulators Market, 2017-2023
Figure 7.8    Canada: Human Microbiome Modulators Market, 2017-2023
Figure 7.9    Europe: Human Microbiome Modulators Market, 2017-2023
Figure 7.10    Europe: Market Dynamics
Figure 7.11    Europe: Human Microbiome Modulators Market (by Country), 2017 and 2023
Figure 7.12    Italy: Human Microbiome Modulators Market, 2017-2023
Figure 7.13    Russia: Human Microbiome Modulators Market, 2017-2023
Figure 7.14    France: Human Microbiome Modulators Market, 2017-2023
Figure 7.15    Poland: Human Microbiome Modulators Market, 2017-2023
Figure 7.16    Germany: Human Microbiome Modulators Market, 2017-2023
Figure 7.17    The U.K.: Human Microbiome Modulators Market, 2017-2023
Figure 7.18    Rest-of-Europe: Human Micorbiome Modulators Market, 2017-2023
Figure 7.19    Asia-Pacific: Human Microbiome Modulators Market, 2017-2023
Figure 7.20    Asia-Pacific: Market Dynamics
Figure 7.21    Asia Pacific: Human Microbiome Modulators Market (by Country), 2017 and 2023
Figure 7.22    Japan: Human Microbiome Modulators Market, 2017-2023
Figure 7.23    Australia: Human Microbiome Modulators Market, 2017-2023
Figure 7.24    South Korea: Human Microbiome Modulators Market, 2017-2023
Figure 7.25    China: Human Microbiome Modulators Market, 2017-2023
Figure 7.26    India: Human Microbiome Modulators Market, 2017-2023
Figure 7.27    Rest-of-Asia Pacific: Human Micorbiome Modulators  Market, 2017-2023
Figure 7.28    Latin America: Human Microbiome Modulators Market, 2017-2023
Figure 7.29    Latin America: Market Dynamics
Figure 7.30    Latin America: Human Microbiome Modulators Market (by Country), 2017 and 2023
Figure 7.31    Brazil: Human Microbiome Modulators Market, 2017-2023
Figure 7.32    Mexico: Human Microbiome Modulators Market, 2017-2023
Figure 7.33    Rest-of-Latin America: Human Microbiome Modulators Market, 2017-2023
Figure 7.34    Rest-of-the-World: Human Microbiome Modulators Market, 2017-2023
Figure 8.1    Total Number of Companies Profiled
Figure 8.2    Bayer AG: Product Portfolio for Human Microbiome Modulators Market
Figure 8.3    Bayer AG: Overall Financials, 2015-2017
Figure 8.4    Bayer AG: Revenue (by Segment), 2015-2017
Figure 8.5    Bayer AG: Revenue (by Region), 2015-2017
Figure 8.6    Bayer AG: R&D Expenditure, 2015-2017
Figure 8.7    Bayer AG: Global Presence, 2015-2017
Figure 8.8    Bayer AG: SWOT Analysis
Figure 8.9    BioGaia AB: Product Portfolio for Human Microbiome Modulators Market
Figure 8.10    BioGaia AB: Overall Financials, 2015-2017
Figure 8.11    BioGaia AB: Revenue (by Segment), 2015-2017
Figure 8.12    BioGaia AB: Revenue (by Region), 2015-2017
Figure 8.13    BioGaia AB: R&D Expenditure, 2015-2017
Figure 8.14    BioGaia AB: Revenue Forecast, 2015-2020
Figure 8.15    BioGaia AB: Global Presence, 2015-2017
Figure 8.16    BioGaia AB: SWOT Analysis
Figure 8.17    Chr. Hansen Holding A/S: Product Portfolio for Human Microbiome Modulators Market
Figure 8.18    Chr. Hansen Holding A/S: Overall Financials, 2015-2017
Figure 8.19    Chr. Hansen Holding A/S: Revenue (by Segment), 2015-2017
Figure 8.20    Chr. Hansen Holding A/S: Revenue (by Region), 2015-2017
Figure 8.21    Chr. Hansen Holding A/S: R&D Expenditure, 2015-2017
Figure 8.22    Chr. Hansen Holding A/S: Revenue Forecast, 2015-2020
Figure 8.23    Chr. Hansen Holding A/S: Global Presence, 2015-2017
Figure 8.24    Chr. Hansen Holding A/S: SWOT Analysis
Figure 8.25    DowDuPont Inc.: Product Portfolio for Human Microbiome Modulators Market
Figure 8.26    DowDuPont Inc.: Overall Financials, 2015-2017
Figure 8.27    DowDuPont Inc.: Revenue (by Segment), 2015-2017
Figure 8.28    DowDuPont Inc.: Revenue (by Region), 2015-2017
Figure 8.29    DowDuPont Inc.: R&D Expenditure, 2015-2017
Figure 8.30    DowDuPont Inc.: Global Presence, 2015-2017
Figure 8.31    DowDuPont Inc.: SWOT Analysis
Figure 8.32    Garden of Life, LLC.: Overall Product Portfolio
Figure 8.33    Garden of Life, LLC.: SWOT Analysis
Figure 8.34    Ingredion Incorporated: Product Portfolio for Human Microbiome Modulators Market
Figure 8.35    Ingredion Incorporated: Overall Financials, 2015-2017
Figure 8.36    Ingredion Incorporated: Revenue (by Segment), 2015-2017
Figure 8.37    Ingredion Incorporated: Revenue (by Region), 2015-2017
Figure 8.38    Ingredion Incorporated: R&D Expenditure, 2015-2017
Figure 8.39    Ingredion Incorporated: Revenue Forecast, 2015-2020
Figure 8.40    Ingredion Incorporated: Global Presence, 2015-2017
Figure 8.41    Ingredion Incorporated: SWOT Analysis
Figure 8.42    ISOThrive LLC.: Overall Product Portfolio
Figure 8.43    ISOThrive LLC: SWOT Analysis
Figure 8.44    Jarrow Formulas, Inc.: Overall Product Portfolio
Figure 8.45    Jarrow Formulas, Inc.: SWOT Analysis
Figure 8.46    Koninklijke DSM N.V.: Product Portfolio for Human Microbiome Modulators Market
Figure 8.47    Koninklijke DSM N.V.: Overall Financials, 2015-2017
Figure 8.48    Koninklijke DSM N.V.: Revenue (by Segment), 2015-2017
Figure 8.49    Koninklijke DSM N.V.: Revenue (by Region), 2015-2017
Figure 8.50    Koninklijke DSM N.V.: R&D Expenditure, 2015-2017
Figure 8.51    Koninklijke DSM N.V.: Global Presence, 2015-2017
Figure 8.52    Koninklijke DSM N.V.: SWOT Analysis
Figure 8.53    Lallemand Inc.: Overall Product Portfolio
Figure 8.54    Lallemand Inc.: SWOT Analysis
Figure 8.55    MicroBiome Therapeutics, LLC: Overall Product Portfolio
Figure 8.56    MicroBiome Therapeutics, LLC: SWOT Analysis
Figure 8.57    Pharmavite LLC: Overall Product Portfolio
Figure 8.58    Pharmavite LLC: SWOT Analysis
Figure 8.59    Probi AB: Product Portfolio for Human Microbiome Modulators Market
Figure 8.60    Probi AB: Overall Financials, 2015-2017
Figure 8.61    Probi AB: Revenue (by Segment), 2015-2017
Figure 8.62    Probi AB: Revenue (by Region), 2015-2017
Figure 8.63    Probi AB: R&D Expenditure, 2015-2017
Figure 8.64    Probi AB: Revenue Forecast, 2015-2020
Figure 8.65    Probi AB: Global Presence, 2015-2017
Figure 8.66    Probi AB: SWOT Analysis
Figure 8.67    ADM Protexin: Overall Product Portfolio
Figure 8.68    ADM Protexin: SWOT Analysis
Figure 8.69    Quorum Innovations, LLC: Overall Product Portfolio
Figure 8.70    Quorum Innovations, LLC: SWOT Analysis
Figure 8.71    Sanofi S.A.: Product Portfolio for Human Microbiome Modulators Market
Figure 8.72    Sanofi S.A.: Overall Financials, 2015-2017
Figure 8.73    Sanofi S.A.: Revenue (by Segment), 2015-2017
Figure 8.74    Sanofi S.A.: Revenue (by Region), 2015-2017
Figure 8.75    Sanofi S.A.: R&D Expenditure, 2015-2017
Figure 8.76    Sanofi S.A.: Revenue Forecast, 2015-2020
Figure 8.77    Sanofi S.A.: SWOT Analysis
Figure 8.78    The Procter and Gamble Company: Product Portfolio for Human Microbiome Modulators Market
Figure 8.79    The Procter and Gamble Company: Overall Financials, 2016-2018
Figure 8.80    The Procter and Gamble Company: Revenue (by Segment), 2016-2018
Figure 8.81    The Procter and Gamble Company: Revenue (by Region), 2016-2018
Figure 8.82    Procter and Gamble Company: R&D Expenditure, 2016-2018
Figure 8.83    The Procter and Gamble Company: Global Presence, 2016-2018
Figure 8.84    The Procter and Gamble Company: SWOT Analysis
Figure 8.85    Yakult Honsha Co., Ltd.: Product Portfolio for Human Microbiome Modulators Market
Figure 8.86    Yakult Honsha Co., Ltd.: Overall Financials, 2015-2017
Figure 8.87    Yakult Honsha Co., Ltd.: Revenue (by Segment), 2015-2017
Figure 8.88    Yakult Honsha Co., Ltd.: Revenue (by Region), 2015-2017
Figure 8.89    Yakult Honsha Co., Ltd.: R&D Expenditure, 2015-2017
Figure 8.90    Yakult Honsha Co., Ltd.: Global Presence, 2015-2017
Figure 8.91    Yakult Honsha Co., Ltd.: SWOT Analysis
Figure 9.1    Global Human Microbiome Modulators Market Segmentation
Figure 9.2    Global Human Microbiome Modulators Market Research Methodology
Figure 9.3    Primary Research
Figure 9.4    Secondary Research
Figure 9.5    Data Triangulation
Figure 9.6    Bottom-up Approach (Segment-wise Analysis)
Figure 9.7    Top-down Approach (Segment-wise Analysis)
Figure 9.8    Assumptions and Limitations
Figure 9.9    Considered Factors for Data Prediction and Modeling

Non-communicable diseases (NCDs) or chronic diseases are a combination of genetic, physiological, behavioral, and environmental factors. Generally tending to be persistent for long durations, NCDs impose immense economic burdens on countries. Given the fact that in 2015, the global healthcare expenditure was estimated by the World Health Organization (WHO) at approximately $7 trillion, the escalating prevalence of NCDs such as diabetes, obesity, cardiovascular diseases, respiratory diseases, and cancers, among others, have significantly driven this expenditure. Expected to reach over $8.5 trillion by 2020, the global health expenditure has been one of the leading causes of economic burden over governments, worldwide.

As of WHO’s estimates in 2016, NCDs are responsible for almost 71% deaths globally, killing 41 million people each year. Also, WHO’s estimates in 2017 report of a global population of 7.55 billion individuals, a recurrent factor in having direct consequences upon increasing the global disease burden. In addition to the aforementioned estimates, the United Nations Department of Economic and Social Affairs/Population Division estimated that the life expectancy increased from 67.2 years to 70.8 years in the years 2010-2015. In the same report, it was also estimated that approximately 13% of the global population was aged 60 years or above. Compounding these factors, the global economic, clinical, and social burden of NCDs has been escalating at a rapid pace.

Another largely undermined factor for the rising global disease burden is antimicrobial resistance (AMR). Largely a natural phenomenon, antimicrobial resistance is triggered by the excess usage of antibiotics for treatment of diseases with microbial origins. A complex issue of global concern, AMR is majorly driven by human action and perverse incentives. The misuse of antibiotics in the medical, agricultural, and veterinary sectors, which also include inappropriate antibiotic prescription, the overuse of antibiotics in the livestock sector, and insufficient hygiene practices in hospital, all contribute significantly to the rise of AMR.

The advent of precision medicine, a patient-centric treatment approach, is perceived to be promising in driving a paradigm shift in the healthcare industry, facilitating the elimination of uncertainty pertaining to trial and error method of medications, and consequently eliminating unnecessary healthcare spending. As an extension of the precision medicine approach through the Human Genome Project (HGP), the Human Microbiome Project (HMP) was implemented to acquire the ‘complete’ scope of the human body for precision care. With results published form the Phase 1 of HMP (HMP1), the scientific scope for disease treatment was significantly expanded by the realization of the central role of the microbial population co-existing with the human body. NCDs, being an area direly in need of immediate therapeutic interventions, have naturally become a prevalent scope for microbiome modulation. Consequently, the evolution of human microbiome modulators has come a long way from addressing only digestive complications via dairy-based probiotics to ongoing clinical trials for microbiome-targeting drugs that address a range of diseases indications.

Till 2010, the healthcare industry was largely dominated by synthetic drug modules catering to major disease indications. However, post-2010, precision care has been the prime target for any therapeutic module. With the microbiome’s unravelling as a central component of human health and disease, precision care has evolved significantly into becoming a more integrative and more personalized approach. As of 2018, the microbiome modulators market can be seen to have exposure in very few countries. However, with the rapid advancements taking place and an exponential progression in the number of companies entering the space, access to consumers is bound to become easier. The global human microbiome modulators market has been witnessing a steady annual growth rate of approximately 6.08% in past three years (2015-2017), and the market is expected to continue to grow with a double digit CAGR of 16.29% during the forecast period, 2018-2023. Growing at a CAGR of 13.92% during the forecast period of 2018-2023, the probiotics and creams product segment is anticipated to generate a value of $1.66 billion in 2023. However, the global market for drugs is anticipated to grow at the fastest CAGR of 22.26% during the forecast period 2018-2023.

The purpose of the study is to gain a holistic view of the global human microbiome modulators market in terms of various factors such as recent trends and product advancements, influencing the market. The scope of this report is centered upon conducting a detailed study of the products allied with the human microbiome modulators market, which includes various products such as probiotics and creams, prebiotics and dietary supplements, and drugs. However, the market estimation only comprises manufacturers of human microbiome modulators. The human microbiome modulators market is segmented into three different parts namely products, applications, and region. The global market value was estimated using these three different approaches and was validated with one another. These segments are further segmented into several sub-segments to ease the market estimation and to gain a holistic view of the market.

Based on the region, the global human microbiome modulators market is segmented into North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World (RoW). North America is the leading contributor to the global human microbiome modulators market and was responsible for a 38.47% share of the global market values in 2017. Also, North America is expected to grow the fastest among all other regions with a CAGR of 18.79% during the forecast period 2018-2023.

The key human microbiome modulator manufacturers who have been contributing significantly to the human microbiome modulator market include Sanofi S.A., The Procter and Gamble Company, Bayer AG, Koninklijke DSM N.V., E. I. du Pont de Nemours and Company, Yakult Honsha Co., Ltd., BioGaia AB, Probi AB, Chr. Hansen Holding A/S, and Ingredion Incorporated, among others.

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In the era of precision medicine, the healthcare industry is focused on the development of advanced therapeutics to deliver improved patient care and enhance treatment outcome. The increasing prevalence of chronic disorders and an overall increased demand for preventive medication with minimal/no side-effect are promoting the growth of the human microbiome modulators market. Thereby, the advent of precision medicine approach and development of individualized care regimes are improving quality of life of the patients and reducing economic, societal, and clinical burden.

Presently, product categories within the human microbiome modulators market include probiotics and creams, prebiotics and dietary supplements, and drugs. Till date, the healthcare industry has witnessed a number of successful products modulating the gut microbiome, addressing digestive health. However, successful research substantiating a more inclusive role of the microbiome in human health and diseases, including immune health, women’s health, oral health, and other health applications such as skin health, have further drawn the attention of several pharmaceutical companies to venture into this lucrative market by either advancing their respective product portfolios or acquiring companies with immense potentials. Further, several players are now focusing on the development of drugs modulating the microbiome, which is anticipated to enhance the growth of the entire market.

The purpose of the study is to gain a holistic view of the global human microbiome modulators market in terms of various factors influencing the market, including regulatory reforms and technological advancements. The market has been segmented into ‘products’, ‘applications’, and ‘regions’. The scope of this report is centered upon conducting a detailed study of the products allied with the human microbiome modulators market. In addition, the study also includes the exhaustive information on the unmet needs, perception on the new products, competitive landscape (including pipeline analysis), market share of leading manufacturers, growth potential of each product, application, and region, as well as other vital information with respect to human microbiome modulators market. The report presents the reader with an opportunity to unlock comprehensive insights with respect to the market and helps in forming well-informed strategic decisions. The research uncovers some of the substantial parameters that must be taken into consideration before entering into the market.

This research report aims at answering various aspects of the global human microbiome modulators market with the help of the key factors driving the market, the restraints, and the current growth opportunities that are going to shape the future trajectory of the market expansion. The report includes an in-depth examination of the key players and recent developments taking place in this market. Moreover, the report includes chapters on market dynamics (market drivers, opportunities, and challenges) and industry analysis as well.

The research study highlights the factors governing the industry attractiveness with Porter’s Five Forces for a comprehensive understanding of the global human microbiome modulators market. Moreover, the study includes detailed product mapping, market estimation, and analysis of key trends in multiple geographical regions, growth of human microbiome modulators market in each region for different applications, and the key strategies and developments by the prominent human microbiome modulators manufacturers.

The answers to the following key questions can be derived from this report:

•    What are the major market drivers, challenges, and opportunities in the global human microbiome modulators market?
•    What are the underlying structures resulting in the emerging trends within the human microbiome modulators industry?
•    What was the market value of the leading segments and sub-segments of the global human microbiome modulators market in 2017?
•    How will each segment of the global human microbiome modulators market grow during the forecast period and what will be the revenue generated by each of the segments by the end of 2023?
•    What are the influencing factors that may affect the market share of the key players?
•    How will the industry evolve during the forecast period, 2018- 2023?
•    What are the key developmental strategies which are being implemented by the key players in order to sustain in the competitive market?
•    What are the key product types in human microbiome modulators market? What are the major benefits of each product type?
•    How has the market been segmented on the basis of application? Which application is dominating the global human microbiome modulators market and its reason? 
•    Who are the key manufacturers in human microbiome modulators market and what are their contributions?
•    What is the status of each major human microbiome modulators manufacturer with respect to their pipeline?
•    What is the scope of each human microbiome modulators product in North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World?
•    What are the key regulatory implications in developed and developing regions for human microbiome modulators?
•    What is the growth potential of human microbiome modulators in each region, including North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World?
•    Which human microbiome modulators product type is having most promising growth and in which application type?

The key manufacturers who have been contributing significantly to the human microbiome modulators market include Sanofi S.A., The Procter and Gamble Company, Bayer AG, Koninklijke DSM N.V., E. I. du Pont de Nemours and Company, Yakult Honsha Co., Ltd., BioGaia AB, Probi AB, Chr. Hansen Holding A/S, Ingredion Incorporated, and Immuron Ltd., among others.

    Executive Summary
    1    Market Overview
          1.1    Classification of Human Microbiome Modulators
          1.2    Historical Perspective of Human Microbiome Modulators
          1.3    The Human Microbiome Project (2007-2016)
          1.4    Impact of Microbiome on Human Physiology
          1.5    Global Footprint
          1.6    Human Microbiome Modulators: Future Potential
 
    2    Market Dynamics
          2.1    Overview
          2.2    Iceberg Analysis
          2.3    Market Drivers
                   2.3.1    Rising Geriatric Population
                   2.3.2    Increasing Incidence of Lifestyle-related Diseases
                   2.3.3    Gradual Demand for Preventive Medication with Minimal/No Side-Effects
                   2.3.4    Limited Success Rate of Drugs Targeting Specific Diseases
          2.4    Market Restraints
                   2.4.1    Insufficient Application-Based Research Hindering Market Pull
                   2.4.2    Lack of Awareness Regarding the Usage of Probiotics and Prebiotics
                   2.4.3    Non-Harmonized Government Regulations on Probiotics and Prebiotics
          2.5    Market Opportunities
                   2.5.1    Massive Scope for Phenomenal Profits through Venturous Investments
                   2.5.2    Integrative Industry-Academia Collaboration
                   2.5.3    Rise of Next-Generation Probiotics
                   2.5.4    Novel Diagnostic Applications
 
    3    Competitive Landscape
          3.1    Key Strategies and Developments
                   3.1.1    Joint Ventures, Collaborations, and Partnerships
                   3.1.2    Fundings and Business Expansion Activities
                   3.1.3    Product Launch
                   3.1.4    Mergers and Acquisitions
                   3.1.5    Product Approvals
          3.2    Market Share Analysis
          3.3    Growth Share Analysis
                   3.3.1    Growth Share Analysis (by Application)
                   3.3.2    Growth Share Analysis (by Company)
                   3.3.3    Growth Share Analysis (by Country)
          3.4    Industry Attractiveness
                   3.4.1    Bargaining Power of Suppliers
                   3.4.2    Bargaining Power of Buyer
                   3.4.3    Threat of New Entrants
                   3.4.4    Threat of Substitute Products
                   3.4.5    Intensity of Competitive Rivalry
          3.5    Product Pipeline Analysis
 
    4    Regulatory Framework
          4.1    Legal Requirements and Framework in the U.S.
                   4.1.1    For Probiotics
                   4.1.2    For Prebiotics/Dietary Fibers
                   4.1.3    For Live Biotherapeutic Products (LBPs)
          4.2    Legal Requirements and Framework in Europe
          4.3    Legal Requirements and Framework in Asia-Pacific
                   4.3.1    Japan
                   4.3.2    China
          4.4    Global Microbiome Consortiums
 
    5    Global Human Microbiome Modulators Market (by Product)
          5.1    Overview
          5.2    Probiotics and Creams
          5.3    Prebiotics and Dietary Supplements
          5.4    Drugs
 
    6    Global Human Microbiome Modulators Market (by Application)
          6.1    Overview
          6.2    Digestive Health
          6.3    Immune Health
          6.4    Women’s Health
          6.5    Oral Health
          6.6    Others
 
    7    Global Human Microbiome Modulators Market (by Region)
          7.1    Analysis of Growth Potential of Different Countries: Global Human Microbiome Modulators Market
          7.2    North America
                   7.2.1    The U.S.
                   7.2.2    Canada
          7.3    Europe
                   7.3.1    Italy
                   7.3.2    Russia
                   7.3.3    France
                   7.3.4    Poland
                   7.3.5    Germany
                   7.3.6    The U.K.
                   7.3.7    Rest-of-Europe
          7.4    Asia-Pacific
                   7.4.1    Japan
                   7.4.2    Australia
                   7.4.3    South Korea
                   7.4.4    China
                   7.4.5    India
                   7.4.6    Rest-of-Asia-Pacific
          7.5    Latin America
                   7.5.1    Brazil
                   7.5.2    Mexico
                   7.5.3    Rest-of-Latin America
          7.6    Rest-of-the-World
 
    8    Company Profiles
          8.1    Overview
          8.2    Bayer AG
                   8.2.1    Company Overview
                   8.2.2    Role of Bayer AG in the Human Microbiome Modulators Market
                   8.2.3    Financials
                   8.2.4    Key Insights about Financial Health of the Company
                   8.2.5    Global Presence
                   8.2.6    SWOT Analysis
          8.3    BioGaia AB
                   8.3.1    Company Overview
                   8.3.2    Role of BioGaia AB in the Human Microbiome Modulators Market
                   8.3.3    Financials
                   8.3.4    Key Insights about Financial Health of the Company
                   8.3.5    Global Presence
                   8.3.6    SWOT Analysis
          8.4    Chr. Hansen Holding A/S
                   8.4.1    Company Overview
                   8.4.2    Role of Chr. Hansen Holding A/S in the Human Microbiome Modulators Market
                   8.4.3    Financials
                   8.4.4    Key Insights about Financial Health of the Company
                   8.4.5    Global Presence
                   8.4.6    SWOT Analysis
          8.5    DowDuPont Inc.
                   8.5.1    Company Overview
                   8.5.2    Role of DowDuPont Inc. in the Human Microbiome Modulators Market
                   8.5.3    Financials
                   8.5.4    Key Insights about Financial Health of the Company
                   8.5.5    Global Presence
                   8.5.6    SWOT Analysis
          8.6    Garden of Life, LLC.
                   8.6.1    Company Overview
                   8.6.2    Role of Garden of Life, LLC. in Human Microbiome Modulators Market
                   8.6.3    SWOT Analysis
          8.7    Ingredion Incorporated
                   8.7.1    Company Overview
                   8.7.2    Role of Ingredion Incorporated in Human Microbiome Modulators Market
                   8.7.3    Financials
                   8.7.4    Key Insights about Financial Health of the Company
                   8.7.5    Global Presence
                   8.7.6    SWOT Analysis
          8.8    ISOThrive LLC
                   8.8.1    Company Overview
                   8.8.2    Role of ISOThrive LLC in the Human Microbiome Modulators Market
                   8.8.3    SWOT Analysis
          8.9    Jarrow Formulas, Inc.
                   8.9.1    Company Overview
                   8.9.2    Role of Jarrow Formulas, Inc. in Human Microbiome Modulators Market
                   8.9.3    SWOT Analysis
         8.10   Koninklijke DSM N.V.
                   8.10.1    Company Overview
                   8.10.2    Role of Koninklijke DSM N.V. in the Human Microbiome Modulators Market
                   8.10.3    Financials
                   8.10.4    Key Insights about Financial Health of the Company
                   8.10.5    Global Presence
                   8.10.6    SWOT Analysis
         8.11   Lallemand Inc.
                   8.11.1    Company Overview
                   8.11.2    Role of Lallemand Inc. in Human Microbiome Modulators Market
                   8.11.3    SWOT Analysis
         8.12   MicroBiome Therapeutics, LLC
                   8.12.1    Company Overview
                   8.12.2    Role of MicroBiome Therapeutics, LLC in Human Microbiome Modulators Market
                   8.12.3    SWOT Analysis
         8.13   Pharmavite LLC
                   8.13.1    Company Overview
                   8.13.2    Role of Pharmavite LLC in Human Microbiome Modulators Market
                   8.13.3    SWOT Analysis
         8.14   Probi AB
                   8.14.1    Company Overview
                   8.14.2    Role of Probi AB in the Human Microbiome Modulators Market
                   8.14.3    Financials
                   8.14.4    Key Insights about Financial Health of the Company
                   8.14.5    Global Presence
                   8.14.6    SWOT Analysis
         8.15   Probiotics International Limited (ADM Protexin)
                   8.15.1    Company Overview
                   8.15.2    Role of ADM Protexin in Human Microbiome Modulators Market
                   8.15.3    SWOT Analysis
         8.16   Quorum Innovations, LLC
                   8.16.1    Company Overview
                   8.16.2    Role of Quorum Innovations, LLC in Human Microbiome Modulators Market
                   8.16.3    SWOT Analysis
         8.17   Sanofi S.A.
                   8.17.1    Company Overview
                   8.17.2    Role of Sanofi S.A. in Human Microbiome Modulators Market
                   8.17.3    Financials
                                 8.17.3.1     Key Insights about Financial Health of the Company
                   8.17.4    SWOT Analysis
         8.18   The Procter and Gamble Company
                   8.18.1    Company Overview
                   8.18.2    Role of The Procter and Gamble Company in the Human Microbiome Modulators Market
                   8.18.3    Financials
                   8.18.4    Key Insights about Financial Health of the Company
                   8.18.5    Global Presence
                   8.18.6    SWOT Analysis
         8.19   Yakult Honsha Co., Ltd.
                   8.19.1    Company Overview
                   8.19.2    Role of Yakult Honsha Co., Ltd. in Human Microbiome Modulators Market
                   8.19.3    Financials
                   8.19.4    Key Insights about Financial Health of the Company
                   8.19.5    Global Presence
                   8.19.6    SWOT Analysis
 
    9    Research Scope and Methodology
          9.1    Report Scope
          9.2    Human Microbiome Modulators Market: Research Methodology
 

List of Tables

Table 2.1    Impact Analysis of Market Drivers
Table 2.2    Impact Analysis of Market Restraints
Table 3.1    R&D Expenditure of Major Human Microbiome Therapeutic Companies (as of FY2017)
Table 4.1    Global Microbiome Consortiums and Their Participants
Table 6.1    Documented Microbial Associations with Disease Status

List of Figures

Figure 1    Antibiotic Resistance (%) in OECD Countries, 2014
Figure 2    Global Value of Precision Medicine Within Healthcare, 2016 and 2020
Figure 3    Impact Analysis of Market Drivers and Market Restraints, 2018-2023
Figure 4    Global Human Microbiome Modulators Market Snapshot
Figure 5    Dominating Segments of Global Human Microbiome Modulators Market, 2017 and 2023
Figure 6    Global Human Microbiome Modulators Market (by Products), 2017 and 2023
Figure 7    Global Human Microbiome Modulators Market (by Application), 2017 and 2023
Figure 8    Global Human Microbiome Modulator Market (by Region), 2017 and 2023
Figure 9    Pipeline Analysis
Figure 10    Vital Strategies Incorporated by Key Players in the Global Human Microbiome Modulators Market
Figure 11    Market Statistics
Figure 12    Market Share Analysis for the Global Human Microbiome Modulators Market, 2017
Figure 1.1    Classification of Human Microbiome Modulators
Figure 1.2    Evolution of Human Microbiome Modulators
Figure 1.3    Significant Milestones from the HMP (Phase 1)
Figure 1.4    Global Human Microbiome Modulators Market, 2017-2023
Figure 2.1    Iceberg Analysis
Figure 2.2    Projected Global Geriatric Population (in billion), 1900-2100
Figure 2.3    Global Deaths Per Year By Cause (WHO), 2016
Figure 2.4    Average Healthcare Expenditure (by OECD Countries), 2015
Figure 3.1    Share of Key Developments and Strategies, January 2014-August 2018
Figure 3.2    Agreement, Collaboration, and Partnership Share (by Companies), January 2014-August 2018
Figure 3.3    Funding and Expansion Activities Share (by Companies), January 2014-August 2018
Figure 3.4    Product Launches Share (by Companies), January 2014-August 2018
Figure 3.5    Merger and Acquisition Share (by Companies), January 2014-August 2018
Figure 3.6    Product Approval Share (by Companies), January 2014-August 2018
Figure 3.7    Market Share Analysis for the Global Human Micorbiome Modulators  Market, 2016
Figure 3.8    Market Share Analysis for Global Human Microbiome Modulators Market, 2017
Figure 3.9    Growth Share Matrix for Global Human Microbiome Modulators Market (by Application), 2017
Figure 3.10    Growth Share Matrix for Global Human Microbiome Modulators Market (by Company), 2017
Figure 3.11    Growth Share Matrix for Global Human Microbiome Modulators Market (by Country), 2017
Figure 3.12    Industy Attractiveness (Porter’s Five Forces Analysis)
Figure 3.13    Bargaining Power of Suppliers: Overall Impact
Figure 3.14    Bargaining Power of Buyers: Overall Impact
Figure 3.15    Threat of New Entrants: Overall Impact
Figure 3.16    Threat of Substitute Products: Overall Impact
Figure 3.17    Intensity of Competitive Rivalry: Overall Impact
Figure 3.18    Pipeline Analysis
Figure 3.19    Distribution of Pipeline Products According to Their Development Stage
Figure 4.1    Guidelines for the Evaluation of Probiotics for Food Use
Figure 4.2    Guidelines for the Chemistry, Manufacturing, and Control of LBPs by the FDA, 2016
Figure 4.3    Guidelines on the Scientific Requirements for Health Claims by the EFSA (2015)
Figure 4.4    Guidelines by the CFDA for Approval of Health Foods
Figure 5.1    Human Microbiome Modulators Market (by Product)
Figure 5.2    Global Human Microbiome Modulators Market (by Product), 2017 and 2023
Figure 5.3    Mechanism of Action of Probiotic in the Gut Microbiome
Figure 5.4    Global Human Microbiome Modulators Market (by Probiotics and Creams), 2017-2023
Figure 5.5    Effects of Prebiotics in Human Body
Figure 5.6    Global Human Microbiome Modulators Market (by Prebiotics and Dietary Supplements), 2017-2023
Figure 5.7    Mechanisms of Action of Human Microbiome Therapeutic Drugs
Figure 5.8    Number of Drugs in Active Development, 2011-2017
Figure 5.9    Global Human Microbiome Modulators Market (by Drugs), 2017-2023
Figure 6.1    Global Human Microbiome Modulators Market (by Application), 2017 and 2023
Figure 6.2    Global Human Microbiome Modulators Market (by Digestive Health), 2017-2023
Figure 6.3    Total Market Size for Digestive Health-related Modulators  (2017-2023)
Figure 6.4    Interdepending Regulators of the Immune System
Figure 6.5    Global Human Microbiome Modulators Market (by Immune Health), 2017-2023
Figure 6.6    Total Market Size for Immune Health-related Modulators  (2017-2023)
Figure 6.7    Inter-related Factors Governing Women’s Health
Figure 6.8    Global Human Microbiome Modulators Market (by Women’s Health), 2017-2023
Figure 6.9    Total Market Size for Women’s Health-related Modulators  (2017-2023)
Figure 6.10    Ecological Shifts in the Oral Microbiome Causing a Diseased Oral Cavity
Figure 6.11    Global Human Microbiome Modulators Market (by Oral Health), 2017-2023
Figure 6.12    Total Market Size for Oral Health-related Modulators  (2017-2023)
Figure 6.13    Global Human Microbiome Modulators Market (by Other Health Applications), 2017-2023
Figure 6.14    Total Market Size for Other Health-related Modulators, 2017-2023
Figure 7.1    Global Human Microbiome Modulators Market Scenario, 2017 and 2023
Figure 7.2    Global Human Microbiome Modulators (by Region), 2017-2023
Figure 7.3    Analysis of Growth Potential (by Countries)
Figure 7.4    North America: Human Microbiome Modulators Market, 2017-2023
Figure 7.5    North America: Market Dynamics
Figure 7.6    North America: Human Microbiome Modulators Market (by Country), 2017 and 2023
Figure 7.7    The U.S: Human Microbiome Modulators Market, 2017-2023
Figure 7.8    Canada: Human Microbiome Modulators Market, 2017-2023
Figure 7.9    Europe: Human Microbiome Modulators Market, 2017-2023
Figure 7.10    Europe: Market Dynamics
Figure 7.11    Europe: Human Microbiome Modulators Market (by Country), 2017 and 2023
Figure 7.12    Italy: Human Microbiome Modulators Market, 2017-2023
Figure 7.13    Russia: Human Microbiome Modulators Market, 2017-2023
Figure 7.14    France: Human Microbiome Modulators Market, 2017-2023
Figure 7.15    Poland: Human Microbiome Modulators Market, 2017-2023
Figure 7.16    Germany: Human Microbiome Modulators Market, 2017-2023
Figure 7.17    The U.K.: Human Microbiome Modulators Market, 2017-2023
Figure 7.18    Rest-of-Europe: Human Micorbiome Modulators Market, 2017-2023
Figure 7.19    Asia-Pacific: Human Microbiome Modulators Market, 2017-2023
Figure 7.20    Asia-Pacific: Market Dynamics
Figure 7.21    Asia Pacific: Human Microbiome Modulators Market (by Country), 2017 and 2023
Figure 7.22    Japan: Human Microbiome Modulators Market, 2017-2023
Figure 7.23    Australia: Human Microbiome Modulators Market, 2017-2023
Figure 7.24    South Korea: Human Microbiome Modulators Market, 2017-2023
Figure 7.25    China: Human Microbiome Modulators Market, 2017-2023
Figure 7.26    India: Human Microbiome Modulators Market, 2017-2023
Figure 7.27    Rest-of-Asia Pacific: Human Micorbiome Modulators  Market, 2017-2023
Figure 7.28    Latin America: Human Microbiome Modulators Market, 2017-2023
Figure 7.29    Latin America: Market Dynamics
Figure 7.30    Latin America: Human Microbiome Modulators Market (by Country), 2017 and 2023
Figure 7.31    Brazil: Human Microbiome Modulators Market, 2017-2023
Figure 7.32    Mexico: Human Microbiome Modulators Market, 2017-2023
Figure 7.33    Rest-of-Latin America: Human Microbiome Modulators Market, 2017-2023
Figure 7.34    Rest-of-the-World: Human Microbiome Modulators Market, 2017-2023
Figure 8.1    Total Number of Companies Profiled
Figure 8.2    Bayer AG: Product Portfolio for Human Microbiome Modulators Market
Figure 8.3    Bayer AG: Overall Financials, 2015-2017
Figure 8.4    Bayer AG: Revenue (by Segment), 2015-2017
Figure 8.5    Bayer AG: Revenue (by Region), 2015-2017
Figure 8.6    Bayer AG: R&D Expenditure, 2015-2017
Figure 8.7    Bayer AG: Global Presence, 2015-2017
Figure 8.8    Bayer AG: SWOT Analysis
Figure 8.9    BioGaia AB: Product Portfolio for Human Microbiome Modulators Market
Figure 8.10    BioGaia AB: Overall Financials, 2015-2017
Figure 8.11    BioGaia AB: Revenue (by Segment), 2015-2017
Figure 8.12    BioGaia AB: Revenue (by Region), 2015-2017
Figure 8.13    BioGaia AB: R&D Expenditure, 2015-2017
Figure 8.14    BioGaia AB: Revenue Forecast, 2015-2020
Figure 8.15    BioGaia AB: Global Presence, 2015-2017
Figure 8.16    BioGaia AB: SWOT Analysis
Figure 8.17    Chr. Hansen Holding A/S: Product Portfolio for Human Microbiome Modulators Market
Figure 8.18    Chr. Hansen Holding A/S: Overall Financials, 2015-2017
Figure 8.19    Chr. Hansen Holding A/S: Revenue (by Segment), 2015-2017
Figure 8.20    Chr. Hansen Holding A/S: Revenue (by Region), 2015-2017
Figure 8.21    Chr. Hansen Holding A/S: R&D Expenditure, 2015-2017
Figure 8.22    Chr. Hansen Holding A/S: Revenue Forecast, 2015-2020
Figure 8.23    Chr. Hansen Holding A/S: Global Presence, 2015-2017
Figure 8.24    Chr. Hansen Holding A/S: SWOT Analysis
Figure 8.25    DowDuPont Inc.: Product Portfolio for Human Microbiome Modulators Market
Figure 8.26    DowDuPont Inc.: Overall Financials, 2015-2017
Figure 8.27    DowDuPont Inc.: Revenue (by Segment), 2015-2017
Figure 8.28    DowDuPont Inc.: Revenue (by Region), 2015-2017
Figure 8.29    DowDuPont Inc.: R&D Expenditure, 2015-2017
Figure 8.30    DowDuPont Inc.: Global Presence, 2015-2017
Figure 8.31    DowDuPont Inc.: SWOT Analysis
Figure 8.32    Garden of Life, LLC.: Overall Product Portfolio
Figure 8.33    Garden of Life, LLC.: SWOT Analysis
Figure 8.34    Ingredion Incorporated: Product Portfolio for Human Microbiome Modulators Market
Figure 8.35    Ingredion Incorporated: Overall Financials, 2015-2017
Figure 8.36    Ingredion Incorporated: Revenue (by Segment), 2015-2017
Figure 8.37    Ingredion Incorporated: Revenue (by Region), 2015-2017
Figure 8.38    Ingredion Incorporated: R&D Expenditure, 2015-2017
Figure 8.39    Ingredion Incorporated: Revenue Forecast, 2015-2020
Figure 8.40    Ingredion Incorporated: Global Presence, 2015-2017
Figure 8.41    Ingredion Incorporated: SWOT Analysis
Figure 8.42    ISOThrive LLC.: Overall Product Portfolio
Figure 8.43    ISOThrive LLC: SWOT Analysis
Figure 8.44    Jarrow Formulas, Inc.: Overall Product Portfolio
Figure 8.45    Jarrow Formulas, Inc.: SWOT Analysis
Figure 8.46    Koninklijke DSM N.V.: Product Portfolio for Human Microbiome Modulators Market
Figure 8.47    Koninklijke DSM N.V.: Overall Financials, 2015-2017
Figure 8.48    Koninklijke DSM N.V.: Revenue (by Segment), 2015-2017
Figure 8.49    Koninklijke DSM N.V.: Revenue (by Region), 2015-2017
Figure 8.50    Koninklijke DSM N.V.: R&D Expenditure, 2015-2017
Figure 8.51    Koninklijke DSM N.V.: Global Presence, 2015-2017
Figure 8.52    Koninklijke DSM N.V.: SWOT Analysis
Figure 8.53    Lallemand Inc.: Overall Product Portfolio
Figure 8.54    Lallemand Inc.: SWOT Analysis
Figure 8.55    MicroBiome Therapeutics, LLC: Overall Product Portfolio
Figure 8.56    MicroBiome Therapeutics, LLC: SWOT Analysis
Figure 8.57    Pharmavite LLC: Overall Product Portfolio
Figure 8.58    Pharmavite LLC: SWOT Analysis
Figure 8.59    Probi AB: Product Portfolio for Human Microbiome Modulators Market
Figure 8.60    Probi AB: Overall Financials, 2015-2017
Figure 8.61    Probi AB: Revenue (by Segment), 2015-2017
Figure 8.62    Probi AB: Revenue (by Region), 2015-2017
Figure 8.63    Probi AB: R&D Expenditure, 2015-2017
Figure 8.64    Probi AB: Revenue Forecast, 2015-2020
Figure 8.65    Probi AB: Global Presence, 2015-2017
Figure 8.66    Probi AB: SWOT Analysis
Figure 8.67    ADM Protexin: Overall Product Portfolio
Figure 8.68    ADM Protexin: SWOT Analysis
Figure 8.69    Quorum Innovations, LLC: Overall Product Portfolio
Figure 8.70    Quorum Innovations, LLC: SWOT Analysis
Figure 8.71    Sanofi S.A.: Product Portfolio for Human Microbiome Modulators Market
Figure 8.72    Sanofi S.A.: Overall Financials, 2015-2017
Figure 8.73    Sanofi S.A.: Revenue (by Segment), 2015-2017
Figure 8.74    Sanofi S.A.: Revenue (by Region), 2015-2017
Figure 8.75    Sanofi S.A.: R&D Expenditure, 2015-2017
Figure 8.76    Sanofi S.A.: Revenue Forecast, 2015-2020
Figure 8.77    Sanofi S.A.: SWOT Analysis
Figure 8.78    The Procter and Gamble Company: Product Portfolio for Human Microbiome Modulators Market
Figure 8.79    The Procter and Gamble Company: Overall Financials, 2016-2018
Figure 8.80    The Procter and Gamble Company: Revenue (by Segment), 2016-2018
Figure 8.81    The Procter and Gamble Company: Revenue (by Region), 2016-2018
Figure 8.82    Procter and Gamble Company: R&D Expenditure, 2016-2018
Figure 8.83    The Procter and Gamble Company: Global Presence, 2016-2018
Figure 8.84    The Procter and Gamble Company: SWOT Analysis
Figure 8.85    Yakult Honsha Co., Ltd.: Product Portfolio for Human Microbiome Modulators Market
Figure 8.86    Yakult Honsha Co., Ltd.: Overall Financials, 2015-2017
Figure 8.87    Yakult Honsha Co., Ltd.: Revenue (by Segment), 2015-2017
Figure 8.88    Yakult Honsha Co., Ltd.: Revenue (by Region), 2015-2017
Figure 8.89    Yakult Honsha Co., Ltd.: R&D Expenditure, 2015-2017
Figure 8.90    Yakult Honsha Co., Ltd.: Global Presence, 2015-2017
Figure 8.91    Yakult Honsha Co., Ltd.: SWOT Analysis
Figure 9.1    Global Human Microbiome Modulators Market Segmentation
Figure 9.2    Global Human Microbiome Modulators Market Research Methodology
Figure 9.3    Primary Research
Figure 9.4    Secondary Research
Figure 9.5    Data Triangulation
Figure 9.6    Bottom-up Approach (Segment-wise Analysis)
Figure 9.7    Top-down Approach (Segment-wise Analysis)
Figure 9.8    Assumptions and Limitations
Figure 9.9    Considered Factors for Data Prediction and Modeling

Non-communicable diseases (NCDs) or chronic diseases are a combination of genetic, physiological, behavioral, and environmental factors. Generally tending to be persistent for long durations, NCDs impose immense economic burdens on countries. Given the fact that in 2015, the global healthcare expenditure was estimated by the World Health Organization (WHO) at approximately $7 trillion, the escalating prevalence of NCDs such as diabetes, obesity, cardiovascular diseases, respiratory diseases, and cancers, among others, have significantly driven this expenditure. Expected to reach over $8.5 trillion by 2020, the global health expenditure has been one of the leading causes of economic burden over governments, worldwide.

As of WHO’s estimates in 2016, NCDs are responsible for almost 71% deaths globally, killing 41 million people each year. Also, WHO’s estimates in 2017 report of a global population of 7.55 billion individuals, a recurrent factor in having direct consequences upon increasing the global disease burden. In addition to the aforementioned estimates, the United Nations Department of Economic and Social Affairs/Population Division estimated that the life expectancy increased from 67.2 years to 70.8 years in the years 2010-2015. In the same report, it was also estimated that approximately 13% of the global population was aged 60 years or above. Compounding these factors, the global economic, clinical, and social burden of NCDs has been escalating at a rapid pace.

Another largely undermined factor for the rising global disease burden is antimicrobial resistance (AMR). Largely a natural phenomenon, antimicrobial resistance is triggered by the excess usage of antibiotics for treatment of diseases with microbial origins. A complex issue of global concern, AMR is majorly driven by human action and perverse incentives. The misuse of antibiotics in the medical, agricultural, and veterinary sectors, which also include inappropriate antibiotic prescription, the overuse of antibiotics in the livestock sector, and insufficient hygiene practices in hospital, all contribute significantly to the rise of AMR.

The advent of precision medicine, a patient-centric treatment approach, is perceived to be promising in driving a paradigm shift in the healthcare industry, facilitating the elimination of uncertainty pertaining to trial and error method of medications, and consequently eliminating unnecessary healthcare spending. As an extension of the precision medicine approach through the Human Genome Project (HGP), the Human Microbiome Project (HMP) was implemented to acquire the ‘complete’ scope of the human body for precision care. With results published form the Phase 1 of HMP (HMP1), the scientific scope for disease treatment was significantly expanded by the realization of the central role of the microbial population co-existing with the human body. NCDs, being an area direly in need of immediate therapeutic interventions, have naturally become a prevalent scope for microbiome modulation. Consequently, the evolution of human microbiome modulators has come a long way from addressing only digestive complications via dairy-based probiotics to ongoing clinical trials for microbiome-targeting drugs that address a range of diseases indications.

Till 2010, the healthcare industry was largely dominated by synthetic drug modules catering to major disease indications. However, post-2010, precision care has been the prime target for any therapeutic module. With the microbiome’s unravelling as a central component of human health and disease, precision care has evolved significantly into becoming a more integrative and more personalized approach. As of 2018, the microbiome modulators market can be seen to have exposure in very few countries. However, with the rapid advancements taking place and an exponential progression in the number of companies entering the space, access to consumers is bound to become easier. The global human microbiome modulators market has been witnessing a steady annual growth rate of approximately 6.08% in past three years (2015-2017), and the market is expected to continue to grow with a double digit CAGR of 16.29% during the forecast period, 2018-2023. Growing at a CAGR of 13.92% during the forecast period of 2018-2023, the probiotics and creams product segment is anticipated to generate a value of $1.66 billion in 2023. However, the global market for drugs is anticipated to grow at the fastest CAGR of 22.26% during the forecast period 2018-2023.

The purpose of the study is to gain a holistic view of the global human microbiome modulators market in terms of various factors such as recent trends and product advancements, influencing the market. The scope of this report is centered upon conducting a detailed study of the products allied with the human microbiome modulators market, which includes various products such as probiotics and creams, prebiotics and dietary supplements, and drugs. However, the market estimation only comprises manufacturers of human microbiome modulators. The human microbiome modulators market is segmented into three different parts namely products, applications, and region. The global market value was estimated using these three different approaches and was validated with one another. These segments are further segmented into several sub-segments to ease the market estimation and to gain a holistic view of the market.

Based on the region, the global human microbiome modulators market is segmented into North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World (RoW). North America is the leading contributor to the global human microbiome modulators market and was responsible for a 38.47% share of the global market values in 2017. Also, North America is expected to grow the fastest among all other regions with a CAGR of 18.79% during the forecast period 2018-2023.

The key human microbiome modulator manufacturers who have been contributing significantly to the human microbiome modulator market include Sanofi S.A., The Procter and Gamble Company, Bayer AG, Koninklijke DSM N.V., E. I. du Pont de Nemours and Company, Yakult Honsha Co., Ltd., BioGaia AB, Probi AB, Chr. Hansen Holding A/S, and Ingredion Incorporated, among others.

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