Ligase Market - A Global and Regional Analysis

Focus on Product, Source, Application, End User, and Country - Analysis and Forecast, 2022-2032

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A quick peek into the report

Market Report Coverage

Global Ligase Market
Forecast Period: 2022-2032
CAGR During Forecast Period: 5.29%

Ligase Market

Base Year

2021

Market Size in 2021

$371.2 Million

Forecast Period

2022-2032

Value Projection and Estimation by 2032

$651.4 Million

CAGR During Forecast Period

5.29%

Number of Tables

28

Number of Pages

197

Number of Figures

148

 

Key Market Players and Competition Synopsis

The companies that are profiled have been selected based on inputs gathered from primary experts and analyzing company coverage, product portfolio, and market penetration.

Some of the prominent names established in this market are:

•    Agilent Technologies, Inc.
•    ArcticZymes Technologies ASA
•    BD
•    Bio-Rad Laboratories, Inc.
•    Codexis, Inc.
•    F. Hoffmann-La Roche Ltd.
•    Merck KGaA
•    New England Biolabs (UK) Ltd.
•    Promega Corporation
•    QIAGEN N.V.
•    SBS Genetech
•    Takara Bio Inc.
•    Thermo Fisher Scientific, Inc.

How Can This Report Add Value to an Organization?

Key players in the market analysed and profiled in the study, consisting of both products-based companies as well as few emerging

Product/Innovation Strategy: The report considers ligase kits and enzymes both from the product-based companies. These companies are actively involved in undertaking significant business strategies to translate success in research and development into the commercial clinical setting.

Growth/Marketing Strategy: Owing to the explosion of massively parallel sequencing and its applications, all areas of healthcare have been affected, particularly enzyme-based molecular diagnostics. The key components in the ligase market consists of diverse range of ligase-based products and ligation kits, generally purchased by the testing companies and the testing services themselves. The entire workflow is well explained in the report along with pricing analysis considering the applications that are used in testing.

Competitive Strategy: Key players in the global ligase market analysed and profiled in the study, consisting of both products-based companies as well as few emerging companies. Moreover, a detailed competitive benchmarking of the players operating in the global ligase market has been done to help the reader understand how players stack against each other, presenting a clear market landscape. Additionally, comprehensive competitive strategies such as partnerships, agreements, and collaborations will aid the reader in understanding the untapped revenue pockets in the market.

Industry & Technology Overview

The global ligase market is projected to reach $651.4 million by 2032 from $371.2 million in 2021.

Global Ligase Market Industry Overview

The global ligase market is projected to reach $651.4 million by 2032 from $371.2 million in 2021, at a CAGR of 5.29% during the forecast period 2022-2032. The growth in the global ligase market is expected to be driven by factors such as the increasing prevalence of infectious and genetic diseases on a global level, rising awareness of enzyme based diagnostic testing and significant number of funding for executing research and development.

Market Lifecycle Stage

The global ligase market is progressing rapidly with a significant increase in the research and development activities pertaining to a wide range of ligase product for disease detection, accentuating their criticality in healthcare. Ligase enzyme has a critical role in the molecular diagnostics approach, as it ensures the safe and effective application of targeted therapeutics. Most of the players in the global ligase market offer products encompassing the ligation kits and enzymes.

Increasing investments in the R&D for enzyme-based molecular diagnostics is one of the major opportunities in the ligase market. Several diagnostics and pharmaceutical companies are working collaboratively on drug development and using ligase as a therapeutic means for applications in several disease indications in order to enable efficient diagnosis, treatment selection, dosage selection, and treatment monitoring.

Figure: Global Ligase Market Snapshot

Global Ligase Market

Source: BIS Research Analysis

Impact

Several techniques are employed in the development of ligase utilization to detect and quantify specific DNA or RNA sequences. This ligase market space has been segmented into applications that includes ligase chain reaction (LCR), ligase detection reaction (LDR), next-generation sequencing (NGS), repeat expansion detection (RED), rolling circle amplification (RCA), proximity ligation assay (PLA), molecular cloning, ligation mediated PCR, mutation detection, and other application such as drug target. Some of these technologies are described briefly as follows:
•    Ligase chain reaction (LCR): LCR is an amplification process that contrasts with polymerase chain reaction (PCR), which includes a thermostable ligase to join two probes or different particles together, which can then be amplified by standard PCR cycling.
•    Ligase detection reaction (LDR): LDR is a ligase chain reaction (LCR) dependent methodology which that involves a single pair of complementary probes to one strand of targeted DNA. This technique utilizes a high fidelity based thermostable DNA ligase that can distinguish against the ligation of mismatched probes.
•    Next-generation sequencing (NGS): In next-generation sequencing, DNA ligase is used to identify the presence of the nucleotide at a specific position in a DNA sequence. The role of this sequencing depends upon the ability of DNA ligase to identify and consolidate bases in an unmistakable way.
•    Ligation mediated PCR: The process of ligation mediated PCR allows to generate prototypical sequencing templates without subcloning from huge molecules, for example-., amplified yeast artificial chromosomes (YACs).

Impact of COVID-19

The current global ligase market comprises kits and enzymes. The unexpected crisis of the pandemic has surged the demand for essentials, and thus, increased the demand for ligase enzymes. There was increased demand for ligase enzymes from biotechnology and pharmaceutical companies. Overall, the impact of COVID-19 on the global ligase market size has been low-moderate. Some of the market players have reported a slight decline in sales. However, there are some new entrants in the global ligase market that are expected to witness a growth in the market. There is also a decline in revenues mostly as a result of the initial phases of the COVID-19 pandemic, which comprised complete lockdowns across countries and major cities, thus interrupting the supply chain. Several other products are under development for years that may take longer than the 2-4 years for commercialization. The pandemic has played a key role in enhancing the growth prospects of ligase-based molecular diagnostics and is expected to indirectly aid in improving the market growth outlook.

Market Segmentation:

Segmentation 1: by Product
•    Quick Ligase
•    T4 DNA Ligase
•    E. coli DNA Ligase
•    Tth DNA Ligase 
•    T4 RNA Ligase 
•    Pfu DNA Ligase  
•    Others

The global ligase market in the products segment is expected to be dominated by T4 DNA ligase. This is due to an increased usage of T4 DNA ligase, and it is the most commonly used ligase type among suppliers offering kits and enzymes to their end users.

Segmentation 2: by Source
•    Archaebacterium
•    Escherichia coli
•    Thermus thermophilus 
•    Pyrococcus furiosus 
•    Others

The global ligase market is dominated by the Escherichia coli source as it is a commonly used ligase to join recombinant ends of molecules before they are introduced into the cell. Products like T4 RNA ligase, T4 DNA ligase, E. coli DNA ligase, and salt T4 DNA ligase are obtained from Escherichia coli in abundance.

Segmentation 3: by Application
•    Ligase Chain Reaction (LCR)
•    Ligase Detection Reaction (LDR) 
•    Next-Generation Sequencing (NGS)
•    Repeat Expansion Detection (RED) 
•    Rolling Circle Amplification (RCA) 
•    Proximity Ligation Assay (PLA)
•    Molecular Cloning 
•    Ligation Mediated PCR 
•    Mutation Detection 
•    Others

The molecular cloning process dominates the application segment and NGS is the emerging diagnostic application in the global ligase market. The increase in the utilization of this procedure is due to various cloning techniques that have been created that fall under molecular cloning to improve the ease and speed at which DNA fragments can be recombined.

Segmentation 4: by End User
•    Research Laboratories and Institutions 
•    Pharmaceutical and Biopharmaceutical Companies 
•    Diagnostic Laboratories
•    Others

The research laboratories and institutions dominate the end-user segment in the global ligase market as research laboratories, particularly are most involved in carrying out the research studies that are focused on the identification of understanding the diagnostic application of ligase enzyme.

Recent Developments in Global Ligase Market

•    In January 2022, ArcticZymes Technologies launched new products such as ArcticZymes R2DTM Ligase, IsoPol BST+ High Concentration Glycerol FREE and M-SAN HQ ELISA Kit and M-SAN HQ
•    In April 2022, Codexis, Inc. and Molecular Assemblies, Inc., partnered to engineer enzymes and deliver differentiated and cost-effective solutions for the enzymatic synthesis of DNA.
•    In May 2022, QIAGEN acquired majority stake of 96% in BLIRT e.u.., a manufacturer of recombinant enzymes for the life science industry based in Gdansk, Poland. The acquisition was carried out to bring companies capabilities to create additional growth prospects to their enzymes and reagents business.
•    In July 2021, Merck invested $282.5 million at its global headquarters in Darmstadt. Company is involved in building a new translational science center for its healthcare business sector as well as a new learning center.

Demand – Drivers and Limitations

Following are the demand drivers for the global ligase market:

•    Growing Need for Ligases in Disease Treatment 
•    Rising Incidence of Diseases such as Cancer and Genetic Disorders
•    Rising Focus of Researchers on Non-Toxic Biocatalyst

The market is expected to face some limitations too due to the following challenges:

•    High Reception Costs Involving Small and Medium Enterprises
•    Variation in the Ability of Ligase to Repair

Analyst Thoughts

According to Nitish Kumar, Principal Analyst, BIS Research, “Global ligase market has evolved to be an integrative aspect of healthcare practices by providing most diagnostic laboratory tests equipped with infectious disease, oncology, and genetics. The massively parallel methods that have now transcended enzyme-based molecular diagnostics further allow the sequencing of entire genomes at very low costs and are expected to grow further in the coming years due to the continuous increase in prognostic assessments for a wide range of diseases."

Table of Contents

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1.1    Product Definition
         1.1.1    Inclusion and Exclusion
1.2    Ligase Market Workflow
1.3    Market Scope
         1.3.1    Scope of the Study
         1.3.2    Key Questions Answered in the Report

2.1    Global Ligase Market: Research Methodology
2.2    Data Sources
         2.2.1    Primary Data Sources
         2.2.2    Secondary Data Sources
2.3    Market Estimation Model
2.4    Criteria for Company Profiling

3.1    Overview
3.2    Market Footprint and Growth Potential, $Million, 2021-2032
3.3    COVID-19 Impact on Global Ligase Market
         3.3.1    Impact on Market Growth Due to COVID-19

4.1    Regulatory Framework Overview
         4.1.1    Regulatory Guidelines of Ligase Enzymes
                     4.1.1.1    Regulatory Framework in the U.S.
                     4.1.1.2    Regulatory Framework in the European Union
4.2    Patent Analysis
         4.2.1    By Region
         4.2.2    By Year

5.1    Overview
5.2    Impact Analysis
5.3    Market Drivers
         5.3.1    Growing Need for Ligases in Disease Treatment
         5.3.2    Rising Incidence of Diseases such as Cancer and Genetic Disorders
         5.3.3    Rising Focus of Researchers on Non-Toxic Biocatalyst
5.4    Market Restraints
         5.4.1    High Reception Costs Involving Small and Medium Enterprises
         5.4.2    Variation in the Ability of Ligase to Repair
5.5    Market Opportunities
         5.5.1    Utilization of PCR-Based Frameworks
         5.5.2    Recuperation of Lost or Rearranged Genetic Information

6.1    Competitive Landscape
         6.1.1    Mergers and Acquisitions
         6.1.2    Synergistic Activities
         6.1.3    Product Launches
         6.1.4    Fundings and Expansions
6.2    Supply Chain Analysis
6.3    Pricing Analysis (by Product)
         6.3.1    Market Share Analysis (2021)
         6.3.2    Growth-Share Analysis (2021)
                     6.3.2.1    Growth-Share Analysis by Company
                     6.3.2.2    Growth-Share Analysis by Application Type
                     6.3.2.3    Growth-Share Analysis by End User

7.1    Product Outlook
         7.1.1    Quick Ligase
         7.1.2    T4 DNA Ligase
         7.1.3    E. coli DNA Ligase
         7.1.4    Tth DNA Ligase
         7.1.5    T4 RNA Ligase
         7.1.6    Pfu DNA Ligase
         7.1.7    Others

8.1    Source Outlook
         8.1.1    Archaebacterium
         8.1.2    Escherichia coli
         8.1.3    Thermus thermophilus
         8.1.4    Pyrococcus furiosus
         8.1.5    Others

9.1    Application Outlook
         9.1.1    Ligase Chain Reaction (LCR)
         9.1.2    Ligase Detection Reaction (LDR)
         9.1.3    Next-Generation Sequencing (NGS)
         9.1.4    Repeat Expansion Detection (RED)
         9.1.5    Rolling Circle Amplification (RCA)
         9.1.6    Proximity Ligation Assay (PLA)
         9.1.7    Molecular Cloning
         9.1.8    Ligation Mediated PCR
         9.1.9    Mutation Detection
         9.1.10    Others

10.1    End User Outlook
           10.1.1    Research Laboratories and Institutions
           10.1.2    Pharmaceutical and Biopharmaceutical Companies
           10.1.3    Diagnostic Laboratories
           10.1.4    Others

11.1    Regional Outlook
11.2    North America
           11.2.1    Key Dynamics
           11.2.2    U.S
           11.2.3    Canada
11.3    Europe
           11.3.1    Key Dynamics
           11.3.2    France
           11.3.3    Germany
           11.3.4    U.K.
           11.3.5    Italy
           11.3.6    Spain
           11.3.7    Rest-of-Europe
11.4    Asia-Pacific (APAC)
           11.4.1    Key Dynamics
           11.4.2    China
           11.4.3    Japan
           11.4.4    India
           11.4.5    Australia
           11.4.6    South Korea
           11.4.7    Rest-of-Asia-Pacific
11.5    Latin America (LATAM)
           11.5.1    Key Dynamics
           11.5.2    Brazil
           11.5.3    Mexico
           11.5.4    Rest-of-the-LATAM
11.6    Rest-of-the-World

12.1    Agilent Technologies, Inc.
          12.1.1    Company Overview
          12.1.2    Role of Agilent Technologies, Inc. in the Global Ligase Market
          12.1.3    Key Competitors of the Company
          12.1.4    Key Customers of the Company
          12.1.5    Financials
          12.1.6    Analyst Perspective
12.2    ArcticZymes Technologies ASA
          12.2.1    Company Overview
          12.2.2    Role of ArcticZymes Technologies ASA in the Global Ligase Market
          12.2.3    Key Competitors of the Company
          12.2.4    Key Customers of the Company
          12.2.5    Corporate Strategies
          12.2.6    Financials
          12.2.7    Analyst Perspective
12.3    BD
          12.3.1    Company Overview
          12.3.2    Role of BD in the Global Ligase Market
          12.3.3    Key Competitors of the Company
          12.3.4    Key Customers of the Company
          12.3.5    Financials
          12.3.6    Analyst Perspective
12.4    Bio-Rad Laboratories, Inc.
          12.4.1    Company Overview
          12.4.2    Role of Bio-Rad Laboratories, Inc. in the Global Ligase Market
          12.4.3    Key Competitors of the Company
          12.4.4    Key Customers of the Company
          12.4.5    Financials
          12.4.6    Analyst Perspective
12.5    Codexis, Inc.
          12.5.1    Company Overview
          12.5.2    Role of Codexis, Inc. in the Global Ligase Market
          12.5.3    Key Competitors of the Company
          12.5.4    Key Customers of the Company
          12.5.5    Corporate Strategies
          12.5.6    Financials
          12.5.7    Analyst Perspective
12.6    F. Hoffmann-La Roche Ltd.
          12.6.1    Company Overview
          12.6.2    Role of F. Hoffmann-La Roche Ltd. in the Global Ligase Market
          12.6.3    Key Competitors of the Company
          12.6.4    Key Customers of the Company
          12.6.5    Corporate Strategies
          12.6.6    Financials
          12.6.7    Analyst Perspective
12.7    Inspiralis Limited, Inc.
          12.7.1    Company Overview
          12.7.2    Role of Inspiralis Limited, Inc. in the Global Ligase Market
          12.7.3    Key Competitors of the Company
          12.7.4    Key Customers of the Company
          12.7.5    Analyst Perspective
12.8    Merck KGaA
          12.8.1    Company Overview
          12.8.2    Role of Merck KGaA in the Global Ligase Market
          12.8.3    Key Competitors of the Company
          12.8.4    Key Customers of the Company
          12.8.5    Corporate Strategies
          12.8.6    Financials
          12.8.7    Analyst Perspective
12.9    New England Biolabs (UK) Ltd.
          12.9.1    Company Overview
          12.9.2    Role of New England Biolabs (UK) Ltd. In the Global Ligase Market
          12.9.3    Key Competitors of the Company
          12.9.4    Analyst Perspective
12.10    Promega Corporation
             12.10.1    Company Overview
             12.10.2    Role of Promega Corporation in the Global Ligase Market
             12.10.3    Key Competitors of the Company
             12.10.4    Analyst Perspective
12.11    QIAGEN N.V.
             12.11.1    Company Overview
             12.11.2    Role of QIAGEN N.V. in the Global Ligase Market
             12.11.3    Key Competitors of the Company
             12.11.4    Key Customers of the Company
             12.11.5    Corporate strategies
             12.11.6    Financials
             12.11.7    Analyst Perspective
12.12    SBS Genetech
             12.12.1    Company Overview
             12.12.2    Role of SBS Genetech in the Global Ligase Market
             12.12.3    Key Competitors of the Company
             12.12.4    Key Customers of the Company
             12.12.5    Analyst Perspective
12.13    Takara Bio Inc.
             12.13.1    Company Overview
             12.13.2    Role of Takara Bio Inc. in the Global Ligase Market
             12.13.3    Key Competitors of the Company
             12.13.4    Key Customers of the Company
             12.13.5    Financials
             12.13.6    Analyst Perspective
12.14    Thermo Fisher Scientific, Inc.
             12.14.1    Company Overview
             12.14.2    Role of Thermo Fisher Scientific, Inc. in the Global Ligase Market
             12.14.3    Key Competitors of the Company
             12.14.4    Key Customers of the Company
             12.14.5    Financials
             12.14.6    Analyst Perspective
12.15    Emerging Companies
             12.15.1    Tinzyme Ltd.
             12.15.2    Hotspot Therapeutics
             12.15.3    Nurix Therapeutics
             12.15.4    Vividion Therapeutics

Table 1:    COVID-19 Impact on Global Ligase Market
Table 2:    Companies Providing Quick Ligase Kits
Table 3:    Companies Providing T4 DNA Ligase Kits
Table 4:    Companies Providing E.coli DNA Ligase
Table 5:    Companies Providing Tth Ligase
Table 6:    Companies Providing T4RNA Ligase
Table 7:    Companies Providing Pfu DNA Ligase
Table 8:    Companies Providing Other DNA Ligase
Table 9:    Companies Using E.coli Source for Products
Table 10:    Companies Providing Thermus thermophilus Source for Products
Table 11:    U.S. Ligase Market (by Application), $Million, 2022, 2026, 2032
Table 12:    Canada Ligase Market, by Application, $Million, 2022, 2026, 2032
Table 13:    France Ligase Market (by Application), $Million, 2022, 2026, 2032
Table 14:    Germany Ligase Market (by Application), $Million, 2022, 2026, 2032
Table 15:    U.K. Ligase Market (by Application), $Million, 2022, 2026, 2032
Table 16:    Italy Ligase Market (by Application), $Million, 2022, 2026, 2032
Table 17:    Spain Ligase Market, by Application, $Million, 2022, 2026, 2032
Table 18:    Rest-of-Europe Ligase Market (by Application), $Million, 2022, 2026, 2032
Table 19:    China Ligase Market, by Application, $Million, 2022, 2026, 2032
Table 20:    Japan Ligase Market, by Application, $Million, 2022, 2026, 2032
Table 21:    India Ligase Market, by Application, $Million, 2022, 2026, 2032
Table 22:    Australia Ligase Market, by Application, $Million, 2022, 2026, 2032
Table 23:    South Korea Ligase Market, by Application, $Million, 2022, 2026, 2032
Table 24:    Rest-of-Asia-Pacific Ligase Market (by Application), $Million, 2022, 2026, 2032
Table 25:    Brazil Ligase Market, by Application, $Million, 2022, 2026, 2032
Table 26:    Mexico Ligase Market (by Application), $Million, 2022, 2026, 2032
Table 27:    Rest-of-LATAM Ligase Market (by Application), $Million, 2022, 2026, 2032
Table 28:    Rest-of-the-World Ligase Market (by Application), $Million, 2022, 2026, 2032

Figure 1:    Growth Strategy by Companies
Figure 2:    Top Eight Infectious Diseases by Disability-Adjusted Life Years (DALY)
Figure 3:    Global Ligase Market (by Product), $Million, 2021 and 2032
Figure 4:    Global Ligase Market (by Source), $Million, 2021 and 2032
Figure 5:    Global Ligase Market (by Application), 2021 and 2032
Figure 6:    Global Ligase Market (by End User), $Million, 2021 and 2032
Figure 7:    Global Ligase Market Snapshot
Figure 8:    Ligase Market Workflow
Figure 9:    Global Ligase Market Segmentation
Figure 10:    Global Ligase Market: Research Methodology
Figure 11:    Primary Research Methodology
Figure 12:    Bottom-Up Approach (Segment-Wise Analysis)
Figure 13:    Top-Down Approach (Segment-Wise Analysis)
Figure 14:    Global Ligase Market, $Million, 2021-2032
Figure 15:    Region-Wise Analysis (January 2019-June 2022) of Patents Related to the Global Ligase market
Figure 16:    Year-Wise Analysis (January 2019-June 2022) of Patents Related to the Global Ligase market
Figure 17:    Market Dynamics
Figure 18:    Likert Scale
Figure 19:    Impact Analysis
Figure 20:    Alzheimer’s Disease Prevalence in the Year 2019 in Men Population
Figure 21:    List of Ligase Type with Respect to Disease Type
Figure 22:    Share of Key Developments and Strategies, January 2019-January 2022
Figure 23:    Share of Acquisitions (by Company), January 2019-January 2022
Figure 24:    Synergistic Activities Share (by Company), January 2019-January 2022
Figure 25:    Product Launches (by Company), January 2019-January 2022
Figure 26:    Share of Funding Activities (by Company), January 2019-January 2022
Figure 27:    Supply Chain Analysis of the Global Ligase Market
Figure 28:    Market Share Analysis for Global Ligase Market, $Million, 2021
Figure 29:    Growth-Share Analysis of the Global Ligase Market (by Company), 2021
Figure 30:    Growth-Share Matrix for Global Ligase Market (by Application Type), 2021
Figure 31:    Growth-Share Matrix for Global Ligase Market (by End User), 2021
Figure 32:    Global Ligase Market (Quick Ligase), $Million, 2021-2032
Figure 33:    Global Ligase Market (Quick Ligase), Million Units, 2021-2032
Figure 34:    Global Ligase Market (T4 DNA Ligase), $Million, 2021-2032
Figure 35:    Global Ligase Market (T4 DNA Ligase), Million Units, 2021-2032
Figure 36:    Global Ligase Market (E. coli Ligase), $Million, 2021-2032
Figure 37:    Global Ligase Market (E. coli Ligase), Million Units, 2021-2032
Figure 38:    Global Ligase Market (Tth DNA Ligase), $Million, 2021-2032
Figure 39:    Global Ligase Market (Tth DNA Ligase), Million Units, 2021-2032
Figure 40:    Global Ligase Market (T4 RNA Ligase), $Million, 2021-2032
Figure 41:    Global Ligase Market (T4 RNA Ligase), Million Units, 2021-2032
Figure 42:    Global Ligase Market (Pfu DNA Ligase), $Million, 2021-2032
Figure 43:    Global Ligase Market (Pfu DNA Ligase), Million Units, 2021-2032
Figure 44:    Global Ligase Market (Others), $Million, 2021-2032
Figure 45:    Global Ligase Market (Others), Million Units, 2021-2032
Figure 46:    Global Ligase Market (Archaebacterium), $Million, 2021-2032
Figure 47:    Global Ligase Market (E. coli), $Million, 2021-2032
Figure 48:    Global Ligase Market (Thermus Thermophillus), $Million, 2021-2032
Figure 49:    Global Ligase Market (Pyrococcus furiosus), $Million, 2021-2032
Figure 50:    Global Ligase Market (Others), $Million, 2021-2032
Figure 51:    Global Ligase Market (Ligase Chain Reaction), $Million, 2021-2032
Figure 52:    Global Ligase Market (Ligase Detection Reaction), $Million, 2021-2032
Figure 53:    Global Ligase Market (Next-Generation Sequencing), $Million, 2021-2032
Figure 54:    Global Ligase Market (Repeat Expansion Detection), $Million, 2021-2032
Figure 55:    Global Ligase Market (Rolling Circle Amplification), $Million, 2021-2032
Figure 56:    Global Ligase Market (Proximity Ligation Assay), $Million, 2021-2032
Figure 57:    Global Ligase Market (Molecular Cloning), $Million, 2021-2032
Figure 58:    Global Ligase Market (Ligation Mediated PCR), $Million, 2021-2032
Figure 59:    Global Ligase Market (Mutation Detection), $Million, 2021-2032
Figure 60:    Global Ligase Market (Others), $Million, 2021-2032
Figure 61:    Global Ligase Market (Research Laboratories and Institutions), $Million, 2021-2032
Figure 62:    Global Ligase Market (Research Laboratories and Institutions), Million Units, 2021-2032
Figure 63:    Global Ligase Market (Pharmaceutical and Biopharmaceutical Companies), $Million, 2021-2032
Figure 64:    Global Ligase Market (Pharmaceutical and Biopharmaceutical Companies), Million Units, 2021-2032
Figure 65:    Global Ligase Market (Diagnostic Laboratories), $Million, 2021-2032
Figure 66:    Global Ligase Market (Diagnostic Laboratories), Million Units, 2021-2032
Figure 67:    Global Ligase Market (Others), $Million, 2021-2032
Figure 68:    Global Ligase Market (Others), Million Units, 2021-2032
Figure 69:    Global Ligase Market Snapshot (by Region)
Figure 70:    Growth Potential Analysis (by Country)
Figure 71:    North America: Market Dynamics
Figure 72:    U.S. Ligase Market, $Million, 2021-2032
Figure 73:    Canada Ligase Market, $Million, 2021-2032
Figure 74:    Growth Potential Analysis (by Country)
Figure 75:    Europe: Market Dynamics
Figure 76:    France Ligase Market, $Million, 2021-2032
Figure 77:    Germany Ligase Market, $Million, 2021-2032
Figure 78:    U.K. Ligase Market, $Million, 2021-2032
Figure 79:    Italy Ligase Market, $Million, 2021-2032
Figure 80:    Spain Ligase Market, $Million, 2021-2032
Figure 81:    Rest-of-Europe Ligase Market, $Million, 2021-2032
Figure 82:    Growth Potential Analysis (by Country)
Figure 83:    APAC: Market Dynamics
Figure 84:    China Ligase Market, $Million, 2021-2032
Figure 85:    Japan Ligase Market, $Million, 2021-2032
Figure 86:    India Ligase Market, $Million, 2021-2032
Figure 87:    Ligase Market, $Million, 2021-2032
Figure 88:    South Korea Ligase Market, $Million, 2021-2032
Figure 89:    Rest-of-Asia-Pacific Ligase Market, $Million, 2021-2032
Figure 90:    Growth Potential Analysis (by Country)
Figure 91:    LATAM: Market Dynamics
Figure 92:    Brazil Ligase Market, $Million, 2021-2032
Figure 93:    Mexico Ligase Market, $Million, 2021-2032
Figure 94:    Rest-of-the-LATAM Ligase Market, $Million, 2021-2032
Figure 95:    Rest-of-the-World Ligase Market, $Million, 2021-2032
Figure 96:    Agilent Technologies, Inc.: Product Portfolio
Figure 97:    Agilent Technologies, Inc.: Overall Financial 2019-2021
Figure 98:    Agilent Technologies, Inc.: Revenue (by Segment), $Million, 2019-2021
Figure 99:    Agilent Technologies, Inc.: Revenue (by Region), $Million, 2019-2021
Figure 100:    Agilent Technologies, Inc: R&D Expenditure, $Million, 2019-2021
Figure 101:    ArcticZymes Technologies ASA: Product Portfolio
Figure 102:    ArcticZymes Technologies ASA: Overall Financials, 2019-2021
Figure 103:    ArcticZymes Technologies ASA: Revenue (by Segment), $Million, 2019-2021
Figure 104:    ArcticZymes Technologies ASA: R&D Expenditure, $Million, 2019-2021
Figure 105:    BD.: Product Portfolio
Figure 106:    BD.: Overall Financials, 2019-2021
Figure 107:    BD.: Revenue (by Segment), $Million, 2019-2021
Figure 108:    BD.: Revenue (by Region), $Million, 2019-2021
Figure 109:    BD.: R&D Expenditure, $Million, 2019-2021
Figure 110:    Bio-Rad Laboratories, Inc.: Product Portfolio
Figure 111:    Bio-Rad Laboratories, Inc.: Overall Financials, 2019-2021
Figure 112:    Bio-Rad Laboratories, Inc.: Revenue (by Segment), $Million, 2019-2021
Figure 113:    Bio-Rad Laboratories, Inc.: Revenue (by Region), $Million, 2019-2021
Figure 114:    Bio-Rad Laboratories, Inc.: R&D Expenditure, $Million, 2019-2021
Figure 115:    Codexis, Inc.: Product Portfolio
Figure 116:    Codexis, Inc.: Overall Financials, 2019-2021
Figure 117:    Codexis, Inc.: Revenue (by Segment), $Million, 2019-2021
Figure 118:    Codexis, Inc.: Revenue (by Region), $Million, 2019-2021
Figure 119:    Codexis, Inc.: R&D Expenditure, $Million, 2019-2021
Figure 120:    F. Hoffmann-La Roche Ltd.: Product Portfolio
Figure 121:    F. Hoffmann-La Roche Ltd.: Overall Financials, 2019-2021
Figure 122:    F. Hoffmann-La Roche Ltd.: Revenue (by Segment), $Million, 2019-2021
Figure 123:    F. Hoffmann-La Roche Ltd.: Revenue (by Region), $Million, 2019-2021
Figure 124:    F. Hoffmann-La Roche Ltd.: R&D Expenditure, $Million, 2019-2021
Figure 125:    Inspiralis Limited, Inc.: Product Portfolio
Figure 126:    Merck KGaA: Product Portfolio
Figure 127:    Merck KGaA: Overall Financials, $Million, 2019-2021
Figure 128:    Merck KGaA: Revenue (by Segment), $Million, 2019-2021
Figure 129:    Merck KGaA: Revenue (by Region), $Million, 2019-2021
Figure 130:    Merck KGaA: R&D Expenditure, $Million, 2019-2021
Figure 131:    New England Biolabs (UK) Ltd.: Product Portfolio
Figure 132:    Promega Corporation: Product Portfolio
Figure 133:    QIAGEN N.V.: Product Portfolio
Figure 134:    QIAGEN N.V.: Overall Financials, 2019-2021
Figure 135:    QIAGEN N.V.: Revenue (by Segment), $Million, 2019-2021
Figure 136:    QIAGEN N.V.: Revenue (by Region), $Million, 2019-2021
Figure 137:    QIAGEN N.V.: R&D Expenditure, 2019-2021
Figure 138:    SBS Genetech: Product Portfolio
Figure 139:    Takara Bio Inc.: Product Portfolio
Figure 140:    Takara Bio Inc.: Overall Financials, 2019-2021
Figure 141:    Takara Bio Inc.: Revenue (by Segment), $Million, 2019-2021
Figure 142:    Takara Bio Inc.: Revenue (by Region), $Million, 2019-2021
Figure 143:    Takara Bio Inc.: R&D Expenditure, $Million, 2019-2021
Figure 144:    Thermo Fisher Scientific, Inc.: Product Portfolio
Figure 145:    Thermo Fisher Scientific, Inc.: Overall Financials, 2019-2021
Figure 146:    Thermo Fisher Scientific, Inc.: Revenue (by Segment), $Million, 2019-2021
Figure 147:    Thermo Fisher Scientific, Inc.: Revenue (by Region), $Million, 2019-2021
Figure 148:    Thermo Fisher Scientific, Inc.: R&D Expenditure, $Million, 2019-2021

Market Report Coverage

Ligase Market

Base Year

2021

Market Size in 2021

$371.2 Million

Forecast Period

2022-2032

Value Projection and Estimation by 2032

$651.4 Million

CAGR During Forecast Period

5.29%

Number of Tables

28

Number of Pages

197

Number of Figures

148

 

Key Market Players and Competition Synopsis

The companies that are profiled have been selected based on inputs gathered from primary experts and analyzing company coverage, product portfolio, and market penetration.

Some of the prominent names established in this market are:

•    Agilent Technologies, Inc.
•    ArcticZymes Technologies ASA
•    BD
•    Bio-Rad Laboratories, Inc.
•    Codexis, Inc.
•    F. Hoffmann-La Roche Ltd.
•    Merck KGaA
•    New England Biolabs (UK) Ltd.
•    Promega Corporation
•    QIAGEN N.V.
•    SBS Genetech
•    Takara Bio Inc.
•    Thermo Fisher Scientific, Inc.

How Can This Report Add Value to an Organization?

Product/Innovation Strategy: The report considers ligase kits and enzymes both from the product-based companies. These companies are actively involved in undertaking significant business strategies to translate success in research and development into the commercial clinical setting.

Growth/Marketing Strategy: Owing to the explosion of massively parallel sequencing and its applications, all areas of healthcare have been affected, particularly enzyme-based molecular diagnostics. The key components in the ligase market consists of diverse range of ligase-based products and ligation kits, generally purchased by the testing companies and the testing services themselves. The entire workflow is well explained in the report along with pricing analysis considering the applications that are used in testing.

Competitive Strategy: Key players in the global ligase market analysed and profiled in the study, consisting of both products-based companies as well as few emerging companies. Moreover, a detailed competitive benchmarking of the players operating in the global ligase market has been done to help the reader understand how players stack against each other, presenting a clear market landscape. Additionally, comprehensive competitive strategies such as partnerships, agreements, and collaborations will aid the reader in understanding the untapped revenue pockets in the market.

Industry & Technology Overview

Global Ligase Market Industry Overview

The global ligase market is projected to reach $651.4 million by 2032 from $371.2 million in 2021, at a CAGR of 5.29% during the forecast period 2022-2032. The growth in the global ligase market is expected to be driven by factors such as the increasing prevalence of infectious and genetic diseases on a global level, rising awareness of enzyme based diagnostic testing and significant number of funding for executing research and development.

Market Lifecycle Stage

The global ligase market is progressing rapidly with a significant increase in the research and development activities pertaining to a wide range of ligase product for disease detection, accentuating their criticality in healthcare. Ligase enzyme has a critical role in the molecular diagnostics approach, as it ensures the safe and effective application of targeted therapeutics. Most of the players in the global ligase market offer products encompassing the ligation kits and enzymes.

Increasing investments in the R&D for enzyme-based molecular diagnostics is one of the major opportunities in the ligase market. Several diagnostics and pharmaceutical companies are working collaboratively on drug development and using ligase as a therapeutic means for applications in several disease indications in order to enable efficient diagnosis, treatment selection, dosage selection, and treatment monitoring.

Figure: Global Ligase Market Snapshot

Global Ligase Market

Source: BIS Research Analysis

Impact

Several techniques are employed in the development of ligase utilization to detect and quantify specific DNA or RNA sequences. This ligase market space has been segmented into applications that includes ligase chain reaction (LCR), ligase detection reaction (LDR), next-generation sequencing (NGS), repeat expansion detection (RED), rolling circle amplification (RCA), proximity ligation assay (PLA), molecular cloning, ligation mediated PCR, mutation detection, and other application such as drug target. Some of these technologies are described briefly as follows:
•    Ligase chain reaction (LCR): LCR is an amplification process that contrasts with polymerase chain reaction (PCR), which includes a thermostable ligase to join two probes or different particles together, which can then be amplified by standard PCR cycling.
•    Ligase detection reaction (LDR): LDR is a ligase chain reaction (LCR) dependent methodology which that involves a single pair of complementary probes to one strand of targeted DNA. This technique utilizes a high fidelity based thermostable DNA ligase that can distinguish against the ligation of mismatched probes.
•    Next-generation sequencing (NGS): In next-generation sequencing, DNA ligase is used to identify the presence of the nucleotide at a specific position in a DNA sequence. The role of this sequencing depends upon the ability of DNA ligase to identify and consolidate bases in an unmistakable way.
•    Ligation mediated PCR: The process of ligation mediated PCR allows to generate prototypical sequencing templates without subcloning from huge molecules, for example-., amplified yeast artificial chromosomes (YACs).

Impact of COVID-19

The current global ligase market comprises kits and enzymes. The unexpected crisis of the pandemic has surged the demand for essentials, and thus, increased the demand for ligase enzymes. There was increased demand for ligase enzymes from biotechnology and pharmaceutical companies. Overall, the impact of COVID-19 on the global ligase market size has been low-moderate. Some of the market players have reported a slight decline in sales. However, there are some new entrants in the global ligase market that are expected to witness a growth in the market. There is also a decline in revenues mostly as a result of the initial phases of the COVID-19 pandemic, which comprised complete lockdowns across countries and major cities, thus interrupting the supply chain. Several other products are under development for years that may take longer than the 2-4 years for commercialization. The pandemic has played a key role in enhancing the growth prospects of ligase-based molecular diagnostics and is expected to indirectly aid in improving the market growth outlook.

Market Segmentation:

Segmentation 1: by Product
•    Quick Ligase
•    T4 DNA Ligase
•    E. coli DNA Ligase
•    Tth DNA Ligase 
•    T4 RNA Ligase 
•    Pfu DNA Ligase  
•    Others

The global ligase market in the products segment is expected to be dominated by T4 DNA ligase. This is due to an increased usage of T4 DNA ligase, and it is the most commonly used ligase type among suppliers offering kits and enzymes to their end users.

Segmentation 2: by Source
•    Archaebacterium
•    Escherichia coli
•    Thermus thermophilus 
•    Pyrococcus furiosus 
•    Others

The global ligase market is dominated by the Escherichia coli source as it is a commonly used ligase to join recombinant ends of molecules before they are introduced into the cell. Products like T4 RNA ligase, T4 DNA ligase, E. coli DNA ligase, and salt T4 DNA ligase are obtained from Escherichia coli in abundance.

Segmentation 3: by Application
•    Ligase Chain Reaction (LCR)
•    Ligase Detection Reaction (LDR) 
•    Next-Generation Sequencing (NGS)
•    Repeat Expansion Detection (RED) 
•    Rolling Circle Amplification (RCA) 
•    Proximity Ligation Assay (PLA)
•    Molecular Cloning 
•    Ligation Mediated PCR 
•    Mutation Detection 
•    Others

The molecular cloning process dominates the application segment and NGS is the emerging diagnostic application in the global ligase market. The increase in the utilization of this procedure is due to various cloning techniques that have been created that fall under molecular cloning to improve the ease and speed at which DNA fragments can be recombined.

Segmentation 4: by End User
•    Research Laboratories and Institutions 
•    Pharmaceutical and Biopharmaceutical Companies 
•    Diagnostic Laboratories
•    Others

The research laboratories and institutions dominate the end-user segment in the global ligase market as research laboratories, particularly are most involved in carrying out the research studies that are focused on the identification of understanding the diagnostic application of ligase enzyme.

Recent Developments in Global Ligase Market

•    In January 2022, ArcticZymes Technologies launched new products such as ArcticZymes R2DTM Ligase, IsoPol BST+ High Concentration Glycerol FREE and M-SAN HQ ELISA Kit and M-SAN HQ
•    In April 2022, Codexis, Inc. and Molecular Assemblies, Inc., partnered to engineer enzymes and deliver differentiated and cost-effective solutions for the enzymatic synthesis of DNA.
•    In May 2022, QIAGEN acquired majority stake of 96% in BLIRT e.u.., a manufacturer of recombinant enzymes for the life science industry based in Gdansk, Poland. The acquisition was carried out to bring companies capabilities to create additional growth prospects to their enzymes and reagents business.
•    In July 2021, Merck invested $282.5 million at its global headquarters in Darmstadt. Company is involved in building a new translational science center for its healthcare business sector as well as a new learning center.

Demand – Drivers and Limitations

Following are the demand drivers for the global ligase market:

•    Growing Need for Ligases in Disease Treatment 
•    Rising Incidence of Diseases such as Cancer and Genetic Disorders
•    Rising Focus of Researchers on Non-Toxic Biocatalyst

The market is expected to face some limitations too due to the following challenges:

•    High Reception Costs Involving Small and Medium Enterprises
•    Variation in the Ability of Ligase to Repair

Analyst Thoughts

According to Nitish Kumar, Principal Analyst, BIS Research, “Global ligase market has evolved to be an integrative aspect of healthcare practices by providing most diagnostic laboratory tests equipped with infectious disease, oncology, and genetics. The massively parallel methods that have now transcended enzyme-based molecular diagnostics further allow the sequencing of entire genomes at very low costs and are expected to grow further in the coming years due to the continuous increase in prognostic assessments for a wide range of diseases."

FAQ's

What is ligase enzyme?

Ligase enzyme is a type of speciality enzyme that promotes the joining of DNA or RNA strands.  It is widely applied in DNA repair, replication, and recombination process.

What are the key trends in the Global Ligase Enzyme?

The key trends in the global ligase market include enzyme based diagnostic procedures that have witnessed significant growth due to research activities for sequencing applications. Rise in the incidence of infectious and genetic disorders. Additionally, a rise in R&D can be seen to develop ligase as therapeutics agents. For example, ArcticZymes Technologies makes novel enzyme to support Next Generation Sequencing (NGS) library preparation and isothermal amplification methods in assay development and point-of-care.

What kind of new strategies is being adopted by the existing market players to strengthen their market position in the ligase industry?

The global ligase market has seen major developments by key players operating in the market, such as business expansion, partnership, collaboration, and product launch. According to BIS Research analysis, the majority of the companies preferred partnership, expansion, investment, and acquisition as a strategy to further increase their growth in the global ligase market. Companies such as Codexis, Inc., Merck KGaA, QIAGEN N.V., F. Hoffmann-La Roche Ltd., and Hotspot Therapeutics have majorly adopted partnerships, acquisitions, and collaborative strategies. 

For a new company looking to enter the global ligase market, which areas could it focus upon to stay ahead of the competition?

A new entrant can focus on various applications that are being offered by the established market players of ligase market.

What is the USP of this report?

o    Extensive competitive benchmarking of top 20 players has been carried out to offer a holistic view of the global ligase market.
o    Market ranking analysis based on product portfolio, recent developments, and regional spread
o    Investment landscape including product adoption scenario, funding, and patent analysis

Who should buy this report?

The ligase enzyme kit providers, pharmaceutical companies, research and academic institutions etc. should buy this report.

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