Global Next Generation Sequencing (NGS) Market

Global Next-Generation Sequencing Market: Focus on Products and Services, Applications, Technology, 18 Countries Data, Industry Insights, and Competitive Landscape – Analysis and Forecast, 2019-2024

The global next-generation sequencing market was $4.93 billion in 2018 and is estimated to grow over $9.91 billion by 2024.

SKU: BH039C
Published Year: 2019
 

The next-generation sequencing (NGS) industry is a multibillion market which consists of multitudinous companies involved in the manufacturing of instruments and kits and consumables and the development of software to bolster the NGS workflow.  NGS has fundamentally changed the genomic research. It enables the scientist to sequence an entire genome, exome, or transcriptome by conducting experiments that were previously impossible. There were some limitations with traditional sequencing platforms. Platforms rely on the reads that are short and are less than 1Kb, further requiring scale up to millions of fragments that are sequenced in parallel.

Advancements in sequencing chemistry, molecular biology, and technical engineering over the years have profoundly increased the sequencing efficiency while decreasing the cost. Impressive progress in these fields have paved the way for the development of massively parallel, high-throughput sequencing technology, known as Next-Generation Sequencing (NGS).

The purpose of this study is to gain a holistic view of the NGS market in terms of various influencing factors, such as trends, technological advancements, role of service providers, and funding scenario in the market. The scope of this report constitutes of an in-depth study of the global next-generation sequencing market, including a thorough analysis of the products across different regions. The market has been segmented into ‘technology’, ‘product’, ‘application’ and ‘geographical regions’. The report presents the reader with an opportunity to unlock comprehensive insights with respect to the market and helps in forming well-informed strategic decisions. The research uncovers some of the substantial parameters that must be taken into consideration before entering into the market.

This research report aims at answering various aspects of the global NGS market with the help of key factors driving the market, restraints, and challenges that can possibly inhibit the overall market growth and the current growth opportunities that are likely to shape the future trajectory of the market expansion. The report includes an in-depth examination of the key ecosystem players and key strategies and developments taking place in this market. In addition, the report includes market dynamics (market drivers, opportunities, and challenges) and industry analysis.

The research study considers the market share analysis for a comprehensive understanding of the global NGS market and assesses the factors governing the same. Funding scenarios, Porter’s Five Force analysis, opportunity matrix, detailed product mapping, pricing analysis, value chain analysis, supply chain of NGS kits and consumables, growth share analysis by products and sequencing instrument provider, and R&D analysis have been included in the report.

The market by region has been further sub-segmented into countries, and the key market trends, key players, and recent developments have been listed in each sub-segment. The answers to the following key questions can be derived from this report:

•    What are the major market drivers, challenges, and opportunities in the global NGS market?
•    How did the NGS market evolve and what is its scope in the future?
•    What was the market share of the leading segments and sub-segments of the global NGS market in 2018?
•    How is each segment of the global NGS market expected to grow during the forecast period, and how much revenue is expected to be generated by each of the segments by the end of 2024?
•    What are the influencing factors that may affect the market share of the key players?
•    What is the influential stake held by the sequencing technology providers in the global NGS market?
•    What is the growth potential of different sequencing technologies in the forecast period 2019-2024?
•    What is expected to be the impact of commercialization of the portable sequencers on global healthcare industry?
•    What are the required features for an instrument to make $100 per genome sequencing a reality?
•    What is industry’s best value chain practice? 
•    Which are the leading raw material providers to the players offering NGS kits and consumables? 
•    What is the market dominance by key players in each region?
•    How is the industry expected to evolve during the forecast period 2019- 2024?
•    What are the key developmental strategies which are being implemented by the key players to stand out in this market?
•    Which are the key service providers of the NGS market?
•    What is the funding scenario for the emerging companies that are investing substantial amount into the development of propitious technologies or products for bringing forth the evolution of the NGS market?
•    How has the market been segmented on the basis of sequencing technology? Which NGS technology is being adopted extensively for undertaking the sequencing procedure?
•    What is the market share of the companies by different segments, namely products, technology, applications, and geography, along with the global share analysis of the market?

The key players which have been contributing significantly to the NGS market include 10x Genomics, Agilent Technologies, Inc., bioMerieux SA, Bio-Rad Laboratories, Inc., Danaher Corporation, F. Hoffmann-La Roche AG, GenapSys, Inc., Illumina, Inc., New England Biolabs, Inc., NuGEN Technologies Inc., Oxford Nanopore Technologies Limited, Pacific Biosciences of California, Inc., PerkinElmer, Inc., QIAGEN, and Thermo Fisher Scientific, among others.

    Executive Summary
    1    Market Overview
          1.1    The Basic NGS Workflow
          1.2    Historical Trends
          1.3    Comparative Analysis of Sanger Sequencing and Next-Generation Sequencing
          1.4    Global NGS Market Scenario
          1.5    Assumptions and Limitations
 
    2    Market Dynamics
          2.1    Impact Analysis
          2.2    Market Drivers
                   2.2.1    Growing Demand for Non-Invasive Diagnosis
                   2.2.2    Technological Advancements in the Field of Computational Biology
                   2.2.3    Growing Prominence of Precision Medicine
          2.3   Market Restraints
                  2.3.1    Uncertain Reimbursement and Regulatory Policies
                  2.3.2    Expensive Sequencing Procedures and Their Applications in Medical Treatments
                  2.3.3    High Capital Requirement Hampering the Expansion of Global Reach
         2.4    Market Opportunities
                  2.4.1    Development of Portable Technologies
                  2.4.2    Hybridization of Technologies
                  2.4.3    Technological Developments in the Field of Bioinformatics and Automation Software
 
    3    Competitive Landscape
          3.1    Key Strategies and Developments
                   3.1.1    Product Launch and Enhancements
                   3.1.2    Collaborations, Partnership, Joint Ventures, and Agreements
                   3.1.3    Mergers and Acquisition
                   3.1.4    Business Expansion and Others
          3.2    Market Share Analysis (2016 and 2017)
                   3.2.1    Market Share Analysis, by Company, by Instruments
                   3.2.2    Market Share Analysis, by Company, by Kits and Consumables
          3.3    Growth Share Analysis
                   3.3.1    Growth Share Analysis (by Products)
                   3.3.2    Growth Share Analysis (by Sequencing Instruments Provider)
          3.4    Value Chain Analysis
                   3.4.1    Value Chain Analysis of Medical Device Industry
                   3.4.2    Value Chain Analysis: Illumina, Inc.
          3.5    $100 per Genome: Era of Predictive and Personalized Medicine
          3.6    Industry Attractiveness
                   3.6.1    Bargaining Power of Suppliers
                   3.6.2    Bargaining Power of Buyer
                   3.6.3    Threat of New Entrants
                   3.6.4    Threat of Substitute Products
                   3.6.5    Intensity of Competitive Rivalry
 
    4    Industry Insights
          4.1    Emerging Companies and Leading Investors of NGS Market
          4.2    Legal Requirements and Regulations
          4.3    Role of Service Provider in the Next-Generation Sequencing Market
 
    5    Global NGS Market (by Product Type)
          5.1    Instruments
          5.2    Kits and Consumables
                   5.2.1    Supply Chain of NGS Kits and Consumables
                               5.2.1.1    Key Challenges for MedTech Supply Chain
                               5.2.1.2    Supply Chain Model: Next-Generation Sequencing Market
                               5.2.1.3    Thermo Fisher Scientific
                               5.2.1.4    QIAGEN N.V.
                               5.2.1.5    PerkinElmer, Inc.
                               5.2.1.6    Pacific Biosciences of California, Inc.
                               5.2.1.7    Oxford Nanopore Technologies Limited.
                               5.2.1.8    NuGEN Technologies, Inc.
                               5.2.1.9    New England Biolabs, Inc.
                               5.2.1.10    Illumina, Inc.
                               5.2.1.11    F. Hoffmann-La Roche AG
                               5.2.1.12    Danaher Corporation
                               5.2.1.13    ASURAGEN, INC
                               5.2.1.14    Agilent Technologies, Inc.
                               5.2.1.15    Adaptive Biotechnologies.
                               5.2.1.16    10x Genomics
           5.3    Software
 
    6    Global NGS Market (by Technology)
          6.1    Reversible Terminator Sequencing
          6.2    Ion Torrent Semiconductor Sequencing
          6.3    Single Molecule Real Time Sequencing (SMRT)
          6.4    Nanopore Sequencing Technology
          6.5    Others
 
    7    Global NGS Market (by Application)
          7.1    Pharmaceuticals
          7.2    Diagnostics
          7.3    Agricultural and Animal Research
          7.4    Forensics
          7.5    Others
 
    8    Global NGS Market (by Region)
          8.1    North America
                   8.1.1    North America: Market Dynamics
                   8.1.2    North America NGS Market (by Product), 2018-2024
                   8.1.3    North America NGS Market: Market Share, by Company
                   8.1.4    North America NGS Market, (by Country)
                               8.1.4.1    The U.S.
                               8.1.4.2    Canada
          8.2    Europe
                   8.2.1    Europe: Market Dynamics
                   8.2.2    Europe NGS Market (by Product), 2018-2024
                   8.2.3    Europe: Market Share, by Company
                   8.2.4    Europe NGS Market, by Country
                               8.2.4.1    Germany
                               8.2.4.2    The U.K.
                               8.2.4.3    France
                               8.2.4.4    Italy
                               8.2.4.5    Spain
                               8.2.4.6    The Netherlands
                               8.2.4.7    Sweden
                               8.2.4.8    Denmark
                               8.2.4.9    Rest-of-Europe
          8.3    Asia-Pacific
                   8.3.1    Asia-Pacific: Market Dynamics
                   8.3.2    Asia-Pacific NGS Market (by Product), 2018-2024
                   8.3.3    Asia-Pacific, by Country
                               8.3.3.1    China
                               8.3.3.2    Japan
                               8.3.3.3    Australia
                               8.3.3.4    India
                               8.3.3.5    South Korea
                               8.3.3.6    Singapore
                               8.3.3.7    Rest-of-the-Asia-Pacific
          8.4    Latin America
                   8.4.1    Latin America: Market Dynamics
                   8.4.2    Latin America NGS Market (by Product), 2018-2024
                   8.4.3    Latin America: Market Share, by Company
                   8.4.4    Latin America, by Country
                               8.4.4.1    Brazil
                               8.4.4.2    Mexico
                               8.4.4.3    Rest-of-Latin America
          8.5    Rest-of-the-World
                   8.5.1    Rest-of-the-World NGS Market (by Product), 2018-2024
 
    9    Company Profiles
          9.1    Overview
          9.2    10x Genomics
                   9.2.1    Company Overview
                   9.2.2    Role of 10x Genomics in the Global NGS Market
                   9.2.3    SWOT Analysis
          9.3    Agilent Technologies, Inc.
                   9.3.1    Company Overview
                   9.3.2    Role of Agilent Technologies, Inc. in the Global NGS Market
                   9.3.3    Financials
                               9.3.3.1    Key Insights about Financial Health of the Company
                   9.3.4    SWOT Analysis
          9.4    Bio-Rad Laboratories, Inc
                   9.4.1    Company Overview
                   9.4.2    Role of Bio-Rad Laboratories, Inc. in the Global NGS Market
                   9.4.3    Financials
                               9.4.3.1    Key Insights about Financial Health of the Company
                   9.4.4    SWOT Analysis
          9.5    BGI
                   9.5.1    Company Overview
                   9.5.2    Role of BGI in the Global NGS Market
                   9.5.3    SWOT Analysis
          9.6    bioMérieux SA
                   9.6.1    Company Overview
                   9.6.2    Role of bioMérieux SA in the Global NGS Market
                   9.6.3    Financials
                               9.6.3.1    Key Insights about Financial Health of the Company
                   9.6.4    SWOT Analysis
          9.7    Danaher Corporation
                   9.7.1    Company Overview
                   9.7.2    Role of Danaher Corporation in the Global NGS Market
                   9.7.3    Financials
                               9.7.3.1    Key Insights about Financial Health of the Company
                   9.7.4    SWOT Analysis
          9.8    F. Hoffmann-La Roche AG
                   9.8.1    Company Overview
                   9.8.2    Role of F. Hoffmann-La Roche AG in the Global NGS Market
                   9.8.3    Financials
                               9.8.3.1    Key Insights about Financial Health of the Company
                   9.8.4    SWOT Analysis
          9.9    Illumina, Inc.
                   9.9.1    Company Overview
                   9.9.2    Role of Illumina, Inc. in the Global NGS Market
                   9.9.3    Financials
                               9.9.3.1    Key Insights about Financial Health of the Company
                   9.9.4    SWOT Analysis
         9.10   New England Biolabs, Inc
                   9.10.1    Company Overview
                   9.10.2    Role of New England Biolabs, Inc. in the Global NGS Market
                   9.10.3    SWOT Analysis
         9.11   NuGEN Technologies, Inc.
                   9.11.1    Company Overview
                   9.11.2    Role of NuGEN Technologies, Inc. in the NGS Market
                   9.11.3    SWOT Analysis
         9.12   Oxford Nanopore Technologies Limited
                   9.12.1    Company Overview
                   9.12.2    Role of Oxford Nanopore Technologies Limited in the Global NGS Market
                   9.12.3    SWOT Analysis
         9.13   Pacific Biosciences of California, Inc.
                   9.13.1    Company Overview
                   9.13.2    Role of Pacific Biosciences of California, Inc. in the Global NGS Market
                   9.13.3    Financials
                                 9.13.3.1    Key Insights on the Financial Health of the Company
                   9.13.4    SWOT Analysis
         9.14   QIAGEN N.V.
                   9.14.1    Company Overview
                   9.14.2    Role of QIAGEN N.V. in the Global NGS Market
                   9.14.3    Financials
                                 9.14.3.1    Key Insights about Financial Health of the Company
                   9.14.4    SWOT Analysis
         9.15   PerkinElmer, Inc.
                   9.15.1    Company Overview
                   9.15.2    Role of PerkinElmer, Inc. in the Global NGS Market
                   9.15.3    Financials
                                 9.15.3.1    Key Insights on the Financial Health of the Company
                   9.15.4    SWOT Analysis
         9.16   Thermo Fisher Scientific
                   9.16.1    Company Overview
                   9.16.2    Role of Thermo Fisher Scientific in the Global NGS Market
                   9.16.3    Financials
                                 9.16.3.1    Key Insights about Financial Health of the Company
                   9.16.4    SWOT Analysis
 
    10    Research Scope and Methodology
            10.1    Report Scope
                       10.1.1    Global Next-Generation Sequencing Market: Research Methodology
                       10.1.2    Primary Data Sources
                       10.1.3    Secondary Data Sources
                       10.1.4    Data Triangulation
                       10.1.5    Assumptions and Limitations
                       10.1.6    Data and Prediction Modelling
 
    11    Annexures
           11.1    Annexure I : Key Developments and Strategies (January 2014 to February 2019)
           11.2    Annexure II : Product Mapping
 

List of Tables

Table 1.1:    Sanger Sequencing vs. Next-Generation Sequencing
Table 2.1:    Impact Analysis
Table 4.1:    Funding Scenario
Table 4.2:    Regulatory Bodies
Table 4.3:    Country-Wise Service Providers
Table 5.1:    Global NGS Instruments Market (by Type), 2018-2024, $Million
Table 5.2:    Global NGS Kits and Consumables Market (by Type), 2018-2024, $Million
Table 5.3:    Few Suppliers of Thermo Fisher Scientific
Table 5.4:    Few Suppliers of QIAGEN N.V.
Table 5.5:    Few Suppliers of PerkinElmer, Inc.
Table 5.6:    Few Suppliers of Pacific Biosciences of California, Inc.
Table 5.7:    Few Suppliers of Oxford Nanopore Technologies Limited.
Table 5.8:    Few Suppliers of NuGEN Technologies, Inc.
Table 5.9:    Few Suppliers of New England Biolabs.
Table 5.10:    Key Offerings of Illumina, Inc.
Table 5.11:    Few Suppliers of Illumina, Inc.
Table 5.12:    Few Suppliers of F. Hoffmann-La Roche AG
Table 5.13:    Few Suppliers of Danaher Corporation
Table 5.14:    Few Suppliers of ASURAGEN, INC.
Table 5.15:    Few Suppliers of Agilent Technologies, Inc.
Table 5.16:    Few Suppliers of Adaptive Biotechnologies.
Table 5.17:    Few Suppliers of 10x Genomics
Table 6.1:    Reversible Terminator Sequencing Country Wise Service Providers
Table 6.2:    Ion Torrent Semiconductor Sequencing Country Wise Service Providers
Table 6.3:    Single Molecule Real-Time Sequencing Country Wise Service Providers
Table 8.1:    North America Next-Generation Sequencing Market (by Product), 2018-2024, $Million
Table 8.2:    Europe Next-Generation Sequencing Market Revenue (by Product), 2018-2024, $Million
Table 8.3:    Asia-Pacific Next-Generation Sequencing Market Revenue (by Product), 2018-2024, $Million
Table 8.4:    Latin America Next-Generation Sequencing Market Revenue (by Product), 2018-2024, $Million
Table 8.5:    Rest-of-the-World: Next-Generation Sequencing Market Revenue (by Product), 2018-2024, $Million

List of Figures

Figure 1:    Drivers and Restraints of Next-Generation Sequencing Market
Figure 2:    Key Strategies Incorporated by Stakeholders of NGS Market, to Sustain the Compatation (from January 2014 to February 2019)
Figure 3:    Leading Service Providers in the Next-Generation Sequencing Market
Figure 4:    Global Next-Generation Sequencing Market, 2018-2024
Figure 5:    Global Next-Generation Sequencing Market Share (by Product), 2018 and 2024
Figure 6:    Global Next-Generation Sequencing Market Share (by Technology), 2018 and 2024
Figure 7:    Global Next-Generation Sequencing Market Share (by Application), 2018 and 2024
Figure 8:    Global Next-Generation Sequencing Market Share (by Region), 2018 and 2024
Figure 1.1:    Different steps in Next-Generation Sequencing Technology
Figure 1.2:    Evolution of Next-Generation Sequencers with Progress in Molecular Technologies
Figure 1.3:    Global Next-Generation Sequencing Market, 2018-2024
Figure 2.1:    Market Dynamics of Global NGS Market
Figure 3.1:    Competitive Landscape, January 2014-February 2019
Figure 3.2:    Share of Key Developments and Strategies, January 2014-February 2019
Figure 3.3:    Product Launch and Enhancements Share (by Companies), January 2014-February 2019
Figure 3.4:    Collaborations, Partnership, Joint Ventures, and Agreements Share (by Companies), January 2014-February 2019
Figure 3.5:    Mergers and Acquisitions Share (by Companies), January 2014-February 2019
Figure 3.6:    Business Expansion and Others Share (by Companies), January 2014-February 2019
Figure 3.7:    Market Share Analysis (by Companies) for the Global Next-Generation Sequencing Market, 2016 and 2017
Figure 3.8:    Market Share Analysis (by Companies) for the Global Next-Generation Sequencing Instruments Market, 2016 and 2017
Figure 3.9:    Market Share Analysis (by Companies) for the Global Next-Generation Sequencing Kits and Consumables Market, 2016 and 2017
Figure 3.10:    Growth Share Matrix for Global Next-Generation Sequencing Market (by Products), 2017
Figure 3.11:    Growth Share Matrix for Global Next-Generation Sequencing Market (by Sequencing Instruments Provider), 2017
Figure 3.12:    Key Entities of Value Chain
Figure 3.13:    Value Chain of Medical Device Industry
Figure 3.14:    Value Chain Analysis: Illumina, Inc.
Figure 3.15:    Cost Per Genome Sequencing ($) vs. Maximum Output of Sequencer Per Run
Figure 3.16:    Maximum Output per Run Required for $100 Genome Sequencing
Figure 4.1:    Level of NGS Service Providers Presence
Figure 5.1:    Global NGS Market (by Product Type)
Figure 5.2:    Global NGS Market (by Product Type), 2018 and 2024
Figure 5.3:    Pivotal Types of Instruments Associated with NGS
Figure 5.4:    Global NGS Instruments Market, 2018-2024
Figure 5.5:    Pivotal Types of Kits & Consumables Associated with NGS
Figure 5.6:    Global NGS Kits & Consumables Market, 2018-2024
Figure 5.7:    Key Entities of Supply Chain
Figure 5.8:    Comparison of MedTech Industry and Total Consumer Industry Supply Chain
Figure 5.9:    Supply Chain Model
Figure 5.10:    Different Types of Computational Platforms
Figure 5.11:    Global NGS Software Market, 2018-2024
Figure 6.1:    Different Types of Sequencing
Figure 6.2:    Global NGS Market (by Technology), 2018 and 2024
Figure 6.3:    Global NGS Market for Reversible Terminator Sequencing, 2018-2024
Figure 6.4:    Global NGS Market for Ion Torrent Semiconductor Sequencing, 2018-2024
Figure 6.5:    Global NGS Market for Single Molecule Real-Time Sequencing, 2018-2024
Figure 6.6:    Global NGS Market for Nanopore Sequencing Technology, 2018-2024
Figure 6.7:    Global NGS Market for Other Technologies, 2018-2024
Figure 7.1:    Leading Fields Which are Witnessing Colossal Incorporation of NGS
Figure 7.2:    Global NGS Market (by Application), 2018-2024
Figure 7.3:    Application of NGS in the field of Pharmaceuticals
Figure 7.4:    Global NGS Market for Pharmaceuticals Applications, 2018-2024
Figure 7.5:    Applications of NGS in the field of Diagnostics
Figure 7.6:    Global NGS Market for Diagnostics Applications, 2018-2024
Figure 7.7:    Global NGS Market for Agricultural and Animal Research Applications, 2018-2024
Figure 7.7:    Global NGS Market for Forensics Applications, 2018-2024
Figure 7.8:    Global NGS Market for Other Applications, 2018-2024
Figure 8.1:    Global Next-Generation Sequencing Market (by Region), 2018 and 2024
Figure 8.2:    North America: Next-Generation Sequencing Market, (2018-2024)
Figure 8.3:    North America: Market Dynamics
Figure 8.4:    Market Share Analysis: North America Sequencing Market, 2016 and 2017
Figure 8.5:    North America: Next-Generation Sequencing Market (by Country), 2018 and 2024
Figure 8.6:    The U.S.: Next-Generation Sequencing Market, 2018-2024
Figure 8.7:    Canada.: Next-Generation Sequencing Market, 2018-2024
Figure 8.8:    Europe: Next-Generation Sequencing Market, (2018-2024)
Figure 8.9:    Europe: Market Dynamics
Figure 8.10:    Market Share Analysis: Europe Sequencing Market, 2016 and 2017
Figure 8.11:    Europe: Next-Generation Sequencing Market (by Country), 2018 and 2024
Figure 8.12:    Germany: Next-Generation Sequencing Market, 2018-2024
Figure 8.13:    The U.K.: Next-Generation Sequencing Market, 2018-2024
Figure 8.14:    France: Next-Generation Sequencing Market, 2018-2024
Figure 8.15:    Italy: Next-Generation Sequencing Market, 2018-2024
Figure 8.16:    Spain: Next-Generation Sequencing Market, 2018-2024
Figure 8.17:    The Netherlands: Next-Generation Sequencing Market, 2018-2024
Figure 8.18:    Sweden: Next-Generation Sequencing Market, 2018-2024
Figure 8.19:    Denmark: Next-Generation Sequencing Market, 2018-2024
Figure 8.20:    Rest-of-Europe: Next-Generation Sequencing Market, 2018-2024
Figure 8.21:    Asia-Pacific: Next-Generation Sequencing Market, (2018-2024)
Figure 8.22:    Asia-Pacific: Market Dynamics
Figure 8.23:    Market Share Analysis: Asia-Pacific Sequencing Market, 2016 and 2017
Figure 8.24:    Asia-Pacific: Next-Generation Sequencing Market (by Country), 2018 and 2024
Figure 8.25:    China: Next-Generation Sequencing Market, 2018-2024
Figure 8.26:    Japan: Next-Generation Sequencing Market, 2018-2024
Figure 8.27:    Australia: Next-Generation Sequencing Market, 2018-2024
Figure 8.28:    India: Next-Generation Sequencing Market, 2018-2024
Figure 8.29:    South Korea: Next-Generation Sequencing Market, 2018-2024
Figure 8.30:    Singapore: Next-Generation Sequencing Market, 2018-2024
Figure 8.31:    Rest-of-the-Asia-Pacific: Next-Generation Sequencing Market, 2018-2024
Figure 8.32:    Latin America: Next-Generation Sequencing Market, (2018-2024)
Figure 8.33:    Latin America: Market Dynamics
Figure 8.34:    Market Share Analysis: Latin America Sequencing Market, 2016 and 2017
Figure 8.35:    Latin America: Next-Generation Sequencing Market (by Country), 2018 and 2024
Figure 8.36:    Brazil: Next-Generation Sequencing Market, 2018-2024
Figure 8.37:    Mexico: Next-Generation Sequencing Market, 2018-2024
Figure 8.38:    Rest-of-Latin America: Next-Generation Sequencing Market, 2018-2024
Figure 8.39:    Rest-of-the-World: Next-Generation Sequencing Market, 2018-2024
Figure 9.1:    Shares of Key Company Profiles
Figure 9.2:    10x Genomics Product Offerings for Global Next-Generation Sequencing Market
Figure 9.3:    10X Genomics: SWOT Analysis
Figure 9.4:    Agilent Technologies, Inc. Product Offerings for Global Next-Generation Sequencing Market
Figure 9.5:    Agilent Technologies, Inc.: Overall Financials, 2016-2018
Figure 9.6:    Agilent Technologies, Inc.: Revenue (by Segment), 2016-2018
Figure 9.7:    Agilent Technologies, Inc.: Revenue (by Region), 2016-2018
Figure 9.8:    Agilent Technologies, Inc.: R&D Expenditure, 2016-2018
Figure 9.9:    Agilent Technologies, Inc.: SWOT Analysis
Figure 9.10:    Bio-Rad Laboratories, Inc. Product Offerings for Global Next-Generation Sequencing Market
Figure 9.11:    Bio-Rad Laboratories, Inc.: Overall Financials, 2015-2017
Figure 9.12:    Bio-Rad Laboratories, Inc.: Revenue (by Segment), 2015-2017
Figure 9.13:    Bio-Rad Laboratories, Inc.: Revenue (by Region), 2015-2017
Figure 9.14:    Bio-Rad Laboratories, Inc.: R&D Expenditure, 2015-2017
Figure 9.15:    Bio-Rad Laboratories, Inc.: SWOT Analysis
Figure 9.16:    BGI Product Offerings for Global Next-Generation Sequencing Market
Figure 9.17:    BGI : SWOT Analysis
Figure 9.18:    bioMérieux SA Product Offerings for Global Next-Generation Sequencing Market
Figure 9.19:    bioMérieux S.A.: Overall Financials, 2015-2017
Figure 9.20:    bioMérieux S.A.: Revenue (by Segment), 2015-2017
Figure 9.21:    bioMérieux S.A.: Revenue (by Region), 2015-2017
Figure 9.22:    bioMérieux S.A.: R&D Expenditure, 2015-2017
Figure 9.23:    bioMérieux SA.: SWOT Analysis
Figure 9.24:    Danaher Corporation Product Offerings for Global Next-Generation Sequencing Market
Figure 9.25:    Danaher Corporation: Overall Financials, 2015-2017
Figure 9.26:    Danaher Corporation: Revenue (by Segment), 2015-2017
Figure 9.27:    Danaher Corporation: Revenue (by Region), 2015-2017
Figure 9.28:    Danaher Corporation: R&D Expenditure, 2015-2017
Figure 9.29:    Danaher Corporation: SWOT Analysis
Figure 9.30:    F. Hoffmann-La Roche AG Product Offerings for Global Next-Generation Sequencing Market
Figure 9.31:    F. Hoffmann-La Roche AG: Overall Financials, 2016-2018
Figure 9.32:    F. Hoffmann-La Roche AG: Revenue (by Segment), 2016-2018
Figure 9.33:    F. Hoffmann-La Roche AG: Revenue (by Region), 2016-2018
Figure 9.34:    F. Hoffmann-La Roche AG: R&D Expenditure, 2016-2018
Figure 9.35:    F. Hoffmann-La Roche AG: SWOT Analysis
Figure 9.36:    Illumina, Inc. Product Offerings for Global Next-Generation Sequencing Market
Figure 9.37:    Illumina, Inc.: Overall Financials, 2016-2018
Figure 9.38:    Illumina, Inc.: Revenue (by Segment), 2016-2018
Figure 9.39:    Illumina, Inc.: Revenue (by Region), 2016-2018
Figure 9.40:    Illumina, Inc.: R&D Expenditure, 2016-2018
Figure 9.41:    Illumina, Inc.: SWOT Analysis
Figure 9.42:    New England Biolabs, Inc Product Offerings for Global Next-Generation Sequencing Market
Figure 9.43:    New England Biolabs, Inc.: SWOT Analysis
Figure 9.44:    NuGEN Technologies, Inc Product Offerings for Global Next-Generation Sequencing Market
Figure 9.45:    NuGEN Technologies, Inc.: SWOT Analysis
Figure 9.46:    Oxford Nanopore Technologies Limited Product Offerings for Global Next-Generation Sequencing Market
Figure 9.47:    Oxford Nanopore Technologies Limited : SWOT Analysis
Figure 9.48:    Pacific Biosciences of California, Inc. Product Offerings for Global Next-Generation Sequencing Market
Figure 9.49:    Pacific Biosciences of California, Inc.: Overall Financials, 2015-2017
Figure 9.50:    Pacific Biosciences of California, Inc.: Net Revenue by Region, 2015-2017
Figure 9.51:    Pacific Biosciences of California, Inc.:R&D Expenditure 2015-2017
Figure 9.52:    Pacific Biosciences of California, Inc.: SWOT Analysis
Figure 9.53:    QIAGEN N.V.: Overall Product Portfolio
Figure 9.54:    QIAGEN N.V.: Overall Financials, 2015-2017
Figure 9.55:    QIAGEN N.V.: Revenue (by Segment), 2015-2017
Figure 9.56:    QIAGEN N.V.: Revenue (by Region), 2015-2017
Figure 9.57:    QIAGEN N.V.: R&D Expenditure, 2015-2017
Figure 9.58:    QIAGEN N.V.: SWOT Analysis
Figure 9.59:    PerkinElmer, Inc. Product Offerings for Global Next-Generation Sequencing Market
Figure 9.60:    PerkinElmer, Inc.: Overall Financials, 2015-2017
Figure 9.61:    PerkinElmer, Inc.: Net Revenue (by Segment), 2015-2017
Figure 9.62:    PerkinElmer, Inc.: Net Revenue (By Region), 2015-2017
Figure 9.63:    PerkinElmer, Inc.: Net Revenue (By Region), 2016-2018
Figure 9.64:    PerkinElmer, Inc.: SWOT Analysis
Figure 9.65:    Thermo Fisher Scientific: Overall Product Portfolio (NGS Market)
Figure 9.66:    Thermo Fisher Scientific: Overall Financials, 2015-2017
Figure 9.67:    Thermo Fisher Scientific: Revenue (by Segment), 2015-2017
Figure 9.68:    Thermo Fisher Scientific: Revenue (by Region), 2015-2017
Figure 9.69:    Thermo Fisher Scientific: R&D Expenditure, 2015-2017
Figure 9.70:    Thermo Fisher Scientific: SWOT Analysis
Figure 10.1:    Next-Generation Sequencing: Market Segmentation
Figure 10.2:    Next-Generation Sequencing Market Segmentation
Figure 10.3:    Primary Research
Figure 10.4:    Secondary Research
Figure 10.5:    Data Triangulation
Figure 10.6:    Top-down Approach (Segment-wise Analysis)
Figure 10.7:    Bottom-up Approach (Segment-wise Analysis)
Figure 10.8:    Assumptions and Limitations
Figure 10.9:    Considered Factors for Data Prediction and Modelling

In the past few years, genome of several species has been sequenced using the automated sanger sequencing. There have been limitations associated with the sanger sequencing, leading to the development of improved sequencing technologies that are capable of sequencing a large number of human genome and are also capable of addressing the problems that were initially hindering growth of the next-generation sequencing (NGS) market. Further, several research centres initiated the designing of the new sequencing technologies which would not require gels and would allow sequencing of a large number of samples in parallel. The three parallel technologies that were introduced in the early 21st century are Polonator, the Heliscope Single Molecule Sequencer Technology, and the Ion Semi-Conductor (Torrent Ion Sequencing).  Since the introduction of these technologies, several attempts were made in the past to generate efficient sequencing technologies that would rely on single molecules, excluding the need for amplification steps. The two promising such technologies are Pacific Single molecule real time (SMRT) DNA sequencing and nanopore DNA sequencing.  The advent of aforementioned technologies has unleased some novel methods which hold the potential to make the $100 genome dream a reality in the near future.  These high-throughput sequencing methods have introduced new fields in the industry, which include analysis of RNA transcript, personal genomics, ChiP-Seq (Chromatin Immunoprecipitation sequencing), and ChiP-chip (Chromatin Immunoprecipitation coupled to DNA microarray), among others.

NGS in the clinical setting requires infrastructure, such as storage and computer capacity, and also the personnel expertise required to comprehensively analyse and interpret the subsequent data.

In addition, the volume of the data needs to be managed skilfully to properly extract the clinically important functions in a robust and clear interface.

The purpose of the study is to gain a holistic view of the next-generation sequencing market in terms of various influencing factors, such as recent trends, technological advancements, and regulatory aspects of the market. The scope of this report is centred upon conducting a detailed study of the technologies allied with the next-generation sequencing market. The global next-generation sequencing market is segmented on the basis of four sections, namely product, technology, application and geography. The global market value was estimated using these four different approaches and was validated with one another. These segments are further segmented into several sub-segments to ease the market estimation and to gain an in-depth view of the market.

The global next-generation sequencing market was $4.93 billion in 2018 and is estimated to grow over $9.91 billion by 2024. The global next-generation sequencing market is expected to grow with a double-digit compound annual growth rate between the years 2019 and 2024. With substantial increase in the demand for genome mapping programs and diagnostics tests based on sequencing, the NGS market is expected to witness an impressive growth and promises to be a lucrative field for investment. In terms of products, the kits and consumables sub-segment dominated the global next-generation sequencing market in 2018. However, the software sub-segment is expected to witness the highest CAGR in the forecast period from 2019 to 2024.

The reversible terminator sequencing technology currently dominates the global NGS market. Nanopore technology is estimated to witness the highest CAGR in the forecast period.

And by application, presently, the pharmaceuticals field holds the largest share of the global next-generation sequencing market and is expected to grow at 13.22% CAGR in the forecast period from 2019 to 2024.  However, with the growing demand for non-invasive diagnostic procedures, the diagnostic field is expected to witness an impressive CAGR in the forecast period from 2019 to 2024. The global next-generation sequencing market is segmented by geographical regions into North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World (RoW). North America is the leading contributor to the global next-generation sequencing market and contributed to 48% of the global market values in 2018. However, Asia-Pacific is expected to grow at a CAGR of 17.25% in the forecast period 2019-2024. Moreover, the Asia Pacific market contributed approximately 18.95% of the total global market value in 2018.

A paradigm shift in the dynamics market is expected in 2023 with the introduction of portable technologies in full scale. The leading players in the market are taking necessary steps to tackle the shift in the dynamics and sustain in the competition. The global next-generation sequencing market is majorly dominated by the U.S. players. Companies belonging to the U.S., such as Illumina, Inc., and Thermo Fisher Scientific, contributed to more than 70% of the market value in 2018. The key players which have significant contributions to the NGS market are 10x Genomics, Agilent Technologies, Inc., bioMérieux SA, Bio-Rad Laboratories, Inc., Danaher Corporation, F. Hoffmann-La Roche AG, GenapSys, Inc., Illumina, Inc., New England Biolabs, Inc., NuGEN Technologies Inc., Oxford Nanopore Technologies Limited, Pacific Biosciences of California, Inc., PerkinElmer, Inc., QIAGEN, and Thermo Fisher Scientific, among others.

The field of service providers for sequencing tests and the applications based on genome sequencing are perceived to be a lucrative business across the globe. With the impressive rise in the demand for sequencing-based diagnostics applications, namely non-invasive prenatal testing, companion diagnostics, and liquid biopsy, the service providing companies have gained popularity and acceptance across the globe. Additionally, substantial investments are being made in bioinformatics startups and service providing companies. With the growing demand for genome mapping programs, a large pool of genomic data is being generated, and the key players of the market are seeking help from the bioinformatics startups to meet the market requirement. Service providing companies help in expanding the global reach of the key players of the market and also play a significant role in increasing the adoptability of sequencing technologies across the globe.

Some of the opportunities on which significant work is being carried out presently in the market are hybridization of technologies and development of portable technologies. The best sequencer is the one with the ability to sequence long reeds, in short run time and with great accuracy. The present available sequencers on the market possess any one of the mentioned features, but not all three. In spite of the substantial investments made by prominent companies to develop the instruments with the aforementioned features, it is not expected to be the reality at any time soon. Thus, the hybridization of available technologies, such as SMRT and reversible semiconductor sequencing technology, is acknowledged to be a promising approach to cater to the needs of the market.

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The next-generation sequencing (NGS) industry is a multibillion market which consists of multitudinous companies involved in the manufacturing of instruments and kits and consumables and the development of software to bolster the NGS workflow.  NGS has fundamentally changed the genomic research. It enables the scientist to sequence an entire genome, exome, or transcriptome by conducting experiments that were previously impossible. There were some limitations with traditional sequencing platforms. Platforms rely on the reads that are short and are less than 1Kb, further requiring scale up to millions of fragments that are sequenced in parallel.

Advancements in sequencing chemistry, molecular biology, and technical engineering over the years have profoundly increased the sequencing efficiency while decreasing the cost. Impressive progress in these fields have paved the way for the development of massively parallel, high-throughput sequencing technology, known as Next-Generation Sequencing (NGS).

The purpose of this study is to gain a holistic view of the NGS market in terms of various influencing factors, such as trends, technological advancements, role of service providers, and funding scenario in the market. The scope of this report constitutes of an in-depth study of the global next-generation sequencing market, including a thorough analysis of the products across different regions. The market has been segmented into ‘technology’, ‘product’, ‘application’ and ‘geographical regions’. The report presents the reader with an opportunity to unlock comprehensive insights with respect to the market and helps in forming well-informed strategic decisions. The research uncovers some of the substantial parameters that must be taken into consideration before entering into the market.

This research report aims at answering various aspects of the global NGS market with the help of key factors driving the market, restraints, and challenges that can possibly inhibit the overall market growth and the current growth opportunities that are likely to shape the future trajectory of the market expansion. The report includes an in-depth examination of the key ecosystem players and key strategies and developments taking place in this market. In addition, the report includes market dynamics (market drivers, opportunities, and challenges) and industry analysis.

The research study considers the market share analysis for a comprehensive understanding of the global NGS market and assesses the factors governing the same. Funding scenarios, Porter’s Five Force analysis, opportunity matrix, detailed product mapping, pricing analysis, value chain analysis, supply chain of NGS kits and consumables, growth share analysis by products and sequencing instrument provider, and R&D analysis have been included in the report.

The market by region has been further sub-segmented into countries, and the key market trends, key players, and recent developments have been listed in each sub-segment. The answers to the following key questions can be derived from this report:

•    What are the major market drivers, challenges, and opportunities in the global NGS market?
•    How did the NGS market evolve and what is its scope in the future?
•    What was the market share of the leading segments and sub-segments of the global NGS market in 2018?
•    How is each segment of the global NGS market expected to grow during the forecast period, and how much revenue is expected to be generated by each of the segments by the end of 2024?
•    What are the influencing factors that may affect the market share of the key players?
•    What is the influential stake held by the sequencing technology providers in the global NGS market?
•    What is the growth potential of different sequencing technologies in the forecast period 2019-2024?
•    What is expected to be the impact of commercialization of the portable sequencers on global healthcare industry?
•    What are the required features for an instrument to make $100 per genome sequencing a reality?
•    What is industry’s best value chain practice? 
•    Which are the leading raw material providers to the players offering NGS kits and consumables? 
•    What is the market dominance by key players in each region?
•    How is the industry expected to evolve during the forecast period 2019- 2024?
•    What are the key developmental strategies which are being implemented by the key players to stand out in this market?
•    Which are the key service providers of the NGS market?
•    What is the funding scenario for the emerging companies that are investing substantial amount into the development of propitious technologies or products for bringing forth the evolution of the NGS market?
•    How has the market been segmented on the basis of sequencing technology? Which NGS technology is being adopted extensively for undertaking the sequencing procedure?
•    What is the market share of the companies by different segments, namely products, technology, applications, and geography, along with the global share analysis of the market?

The key players which have been contributing significantly to the NGS market include 10x Genomics, Agilent Technologies, Inc., bioMerieux SA, Bio-Rad Laboratories, Inc., Danaher Corporation, F. Hoffmann-La Roche AG, GenapSys, Inc., Illumina, Inc., New England Biolabs, Inc., NuGEN Technologies Inc., Oxford Nanopore Technologies Limited, Pacific Biosciences of California, Inc., PerkinElmer, Inc., QIAGEN, and Thermo Fisher Scientific, among others.

    Executive Summary
    1    Market Overview
          1.1    The Basic NGS Workflow
          1.2    Historical Trends
          1.3    Comparative Analysis of Sanger Sequencing and Next-Generation Sequencing
          1.4    Global NGS Market Scenario
          1.5    Assumptions and Limitations
 
    2    Market Dynamics
          2.1    Impact Analysis
          2.2    Market Drivers
                   2.2.1    Growing Demand for Non-Invasive Diagnosis
                   2.2.2    Technological Advancements in the Field of Computational Biology
                   2.2.3    Growing Prominence of Precision Medicine
          2.3   Market Restraints
                  2.3.1    Uncertain Reimbursement and Regulatory Policies
                  2.3.2    Expensive Sequencing Procedures and Their Applications in Medical Treatments
                  2.3.3    High Capital Requirement Hampering the Expansion of Global Reach
         2.4    Market Opportunities
                  2.4.1    Development of Portable Technologies
                  2.4.2    Hybridization of Technologies
                  2.4.3    Technological Developments in the Field of Bioinformatics and Automation Software
 
    3    Competitive Landscape
          3.1    Key Strategies and Developments
                   3.1.1    Product Launch and Enhancements
                   3.1.2    Collaborations, Partnership, Joint Ventures, and Agreements
                   3.1.3    Mergers and Acquisition
                   3.1.4    Business Expansion and Others
          3.2    Market Share Analysis (2016 and 2017)
                   3.2.1    Market Share Analysis, by Company, by Instruments
                   3.2.2    Market Share Analysis, by Company, by Kits and Consumables
          3.3    Growth Share Analysis
                   3.3.1    Growth Share Analysis (by Products)
                   3.3.2    Growth Share Analysis (by Sequencing Instruments Provider)
          3.4    Value Chain Analysis
                   3.4.1    Value Chain Analysis of Medical Device Industry
                   3.4.2    Value Chain Analysis: Illumina, Inc.
          3.5    $100 per Genome: Era of Predictive and Personalized Medicine
          3.6    Industry Attractiveness
                   3.6.1    Bargaining Power of Suppliers
                   3.6.2    Bargaining Power of Buyer
                   3.6.3    Threat of New Entrants
                   3.6.4    Threat of Substitute Products
                   3.6.5    Intensity of Competitive Rivalry
 
    4    Industry Insights
          4.1    Emerging Companies and Leading Investors of NGS Market
          4.2    Legal Requirements and Regulations
          4.3    Role of Service Provider in the Next-Generation Sequencing Market
 
    5    Global NGS Market (by Product Type)
          5.1    Instruments
          5.2    Kits and Consumables
                   5.2.1    Supply Chain of NGS Kits and Consumables
                               5.2.1.1    Key Challenges for MedTech Supply Chain
                               5.2.1.2    Supply Chain Model: Next-Generation Sequencing Market
                               5.2.1.3    Thermo Fisher Scientific
                               5.2.1.4    QIAGEN N.V.
                               5.2.1.5    PerkinElmer, Inc.
                               5.2.1.6    Pacific Biosciences of California, Inc.
                               5.2.1.7    Oxford Nanopore Technologies Limited.
                               5.2.1.8    NuGEN Technologies, Inc.
                               5.2.1.9    New England Biolabs, Inc.
                               5.2.1.10    Illumina, Inc.
                               5.2.1.11    F. Hoffmann-La Roche AG
                               5.2.1.12    Danaher Corporation
                               5.2.1.13    ASURAGEN, INC
                               5.2.1.14    Agilent Technologies, Inc.
                               5.2.1.15    Adaptive Biotechnologies.
                               5.2.1.16    10x Genomics
           5.3    Software
 
    6    Global NGS Market (by Technology)
          6.1    Reversible Terminator Sequencing
          6.2    Ion Torrent Semiconductor Sequencing
          6.3    Single Molecule Real Time Sequencing (SMRT)
          6.4    Nanopore Sequencing Technology
          6.5    Others
 
    7    Global NGS Market (by Application)
          7.1    Pharmaceuticals
          7.2    Diagnostics
          7.3    Agricultural and Animal Research
          7.4    Forensics
          7.5    Others
 
    8    Global NGS Market (by Region)
          8.1    North America
                   8.1.1    North America: Market Dynamics
                   8.1.2    North America NGS Market (by Product), 2018-2024
                   8.1.3    North America NGS Market: Market Share, by Company
                   8.1.4    North America NGS Market, (by Country)
                               8.1.4.1    The U.S.
                               8.1.4.2    Canada
          8.2    Europe
                   8.2.1    Europe: Market Dynamics
                   8.2.2    Europe NGS Market (by Product), 2018-2024
                   8.2.3    Europe: Market Share, by Company
                   8.2.4    Europe NGS Market, by Country
                               8.2.4.1    Germany
                               8.2.4.2    The U.K.
                               8.2.4.3    France
                               8.2.4.4    Italy
                               8.2.4.5    Spain
                               8.2.4.6    The Netherlands
                               8.2.4.7    Sweden
                               8.2.4.8    Denmark
                               8.2.4.9    Rest-of-Europe
          8.3    Asia-Pacific
                   8.3.1    Asia-Pacific: Market Dynamics
                   8.3.2    Asia-Pacific NGS Market (by Product), 2018-2024
                   8.3.3    Asia-Pacific, by Country
                               8.3.3.1    China
                               8.3.3.2    Japan
                               8.3.3.3    Australia
                               8.3.3.4    India
                               8.3.3.5    South Korea
                               8.3.3.6    Singapore
                               8.3.3.7    Rest-of-the-Asia-Pacific
          8.4    Latin America
                   8.4.1    Latin America: Market Dynamics
                   8.4.2    Latin America NGS Market (by Product), 2018-2024
                   8.4.3    Latin America: Market Share, by Company
                   8.4.4    Latin America, by Country
                               8.4.4.1    Brazil
                               8.4.4.2    Mexico
                               8.4.4.3    Rest-of-Latin America
          8.5    Rest-of-the-World
                   8.5.1    Rest-of-the-World NGS Market (by Product), 2018-2024
 
    9    Company Profiles
          9.1    Overview
          9.2    10x Genomics
                   9.2.1    Company Overview
                   9.2.2    Role of 10x Genomics in the Global NGS Market
                   9.2.3    SWOT Analysis
          9.3    Agilent Technologies, Inc.
                   9.3.1    Company Overview
                   9.3.2    Role of Agilent Technologies, Inc. in the Global NGS Market
                   9.3.3    Financials
                               9.3.3.1    Key Insights about Financial Health of the Company
                   9.3.4    SWOT Analysis
          9.4    Bio-Rad Laboratories, Inc
                   9.4.1    Company Overview
                   9.4.2    Role of Bio-Rad Laboratories, Inc. in the Global NGS Market
                   9.4.3    Financials
                               9.4.3.1    Key Insights about Financial Health of the Company
                   9.4.4    SWOT Analysis
          9.5    BGI
                   9.5.1    Company Overview
                   9.5.2    Role of BGI in the Global NGS Market
                   9.5.3    SWOT Analysis
          9.6    bioMérieux SA
                   9.6.1    Company Overview
                   9.6.2    Role of bioMérieux SA in the Global NGS Market
                   9.6.3    Financials
                               9.6.3.1    Key Insights about Financial Health of the Company
                   9.6.4    SWOT Analysis
          9.7    Danaher Corporation
                   9.7.1    Company Overview
                   9.7.2    Role of Danaher Corporation in the Global NGS Market
                   9.7.3    Financials
                               9.7.3.1    Key Insights about Financial Health of the Company
                   9.7.4    SWOT Analysis
          9.8    F. Hoffmann-La Roche AG
                   9.8.1    Company Overview
                   9.8.2    Role of F. Hoffmann-La Roche AG in the Global NGS Market
                   9.8.3    Financials
                               9.8.3.1    Key Insights about Financial Health of the Company
                   9.8.4    SWOT Analysis
          9.9    Illumina, Inc.
                   9.9.1    Company Overview
                   9.9.2    Role of Illumina, Inc. in the Global NGS Market
                   9.9.3    Financials
                               9.9.3.1    Key Insights about Financial Health of the Company
                   9.9.4    SWOT Analysis
         9.10   New England Biolabs, Inc
                   9.10.1    Company Overview
                   9.10.2    Role of New England Biolabs, Inc. in the Global NGS Market
                   9.10.3    SWOT Analysis
         9.11   NuGEN Technologies, Inc.
                   9.11.1    Company Overview
                   9.11.2    Role of NuGEN Technologies, Inc. in the NGS Market
                   9.11.3    SWOT Analysis
         9.12   Oxford Nanopore Technologies Limited
                   9.12.1    Company Overview
                   9.12.2    Role of Oxford Nanopore Technologies Limited in the Global NGS Market
                   9.12.3    SWOT Analysis
         9.13   Pacific Biosciences of California, Inc.
                   9.13.1    Company Overview
                   9.13.2    Role of Pacific Biosciences of California, Inc. in the Global NGS Market
                   9.13.3    Financials
                                 9.13.3.1    Key Insights on the Financial Health of the Company
                   9.13.4    SWOT Analysis
         9.14   QIAGEN N.V.
                   9.14.1    Company Overview
                   9.14.2    Role of QIAGEN N.V. in the Global NGS Market
                   9.14.3    Financials
                                 9.14.3.1    Key Insights about Financial Health of the Company
                   9.14.4    SWOT Analysis
         9.15   PerkinElmer, Inc.
                   9.15.1    Company Overview
                   9.15.2    Role of PerkinElmer, Inc. in the Global NGS Market
                   9.15.3    Financials
                                 9.15.3.1    Key Insights on the Financial Health of the Company
                   9.15.4    SWOT Analysis
         9.16   Thermo Fisher Scientific
                   9.16.1    Company Overview
                   9.16.2    Role of Thermo Fisher Scientific in the Global NGS Market
                   9.16.3    Financials
                                 9.16.3.1    Key Insights about Financial Health of the Company
                   9.16.4    SWOT Analysis
 
    10    Research Scope and Methodology
            10.1    Report Scope
                       10.1.1    Global Next-Generation Sequencing Market: Research Methodology
                       10.1.2    Primary Data Sources
                       10.1.3    Secondary Data Sources
                       10.1.4    Data Triangulation
                       10.1.5    Assumptions and Limitations
                       10.1.6    Data and Prediction Modelling
 
    11    Annexures
           11.1    Annexure I : Key Developments and Strategies (January 2014 to February 2019)
           11.2    Annexure II : Product Mapping
 

List of Tables

Table 1.1:    Sanger Sequencing vs. Next-Generation Sequencing
Table 2.1:    Impact Analysis
Table 4.1:    Funding Scenario
Table 4.2:    Regulatory Bodies
Table 4.3:    Country-Wise Service Providers
Table 5.1:    Global NGS Instruments Market (by Type), 2018-2024, $Million
Table 5.2:    Global NGS Kits and Consumables Market (by Type), 2018-2024, $Million
Table 5.3:    Few Suppliers of Thermo Fisher Scientific
Table 5.4:    Few Suppliers of QIAGEN N.V.
Table 5.5:    Few Suppliers of PerkinElmer, Inc.
Table 5.6:    Few Suppliers of Pacific Biosciences of California, Inc.
Table 5.7:    Few Suppliers of Oxford Nanopore Technologies Limited.
Table 5.8:    Few Suppliers of NuGEN Technologies, Inc.
Table 5.9:    Few Suppliers of New England Biolabs.
Table 5.10:    Key Offerings of Illumina, Inc.
Table 5.11:    Few Suppliers of Illumina, Inc.
Table 5.12:    Few Suppliers of F. Hoffmann-La Roche AG
Table 5.13:    Few Suppliers of Danaher Corporation
Table 5.14:    Few Suppliers of ASURAGEN, INC.
Table 5.15:    Few Suppliers of Agilent Technologies, Inc.
Table 5.16:    Few Suppliers of Adaptive Biotechnologies.
Table 5.17:    Few Suppliers of 10x Genomics
Table 6.1:    Reversible Terminator Sequencing Country Wise Service Providers
Table 6.2:    Ion Torrent Semiconductor Sequencing Country Wise Service Providers
Table 6.3:    Single Molecule Real-Time Sequencing Country Wise Service Providers
Table 8.1:    North America Next-Generation Sequencing Market (by Product), 2018-2024, $Million
Table 8.2:    Europe Next-Generation Sequencing Market Revenue (by Product), 2018-2024, $Million
Table 8.3:    Asia-Pacific Next-Generation Sequencing Market Revenue (by Product), 2018-2024, $Million
Table 8.4:    Latin America Next-Generation Sequencing Market Revenue (by Product), 2018-2024, $Million
Table 8.5:    Rest-of-the-World: Next-Generation Sequencing Market Revenue (by Product), 2018-2024, $Million

List of Figures

Figure 1:    Drivers and Restraints of Next-Generation Sequencing Market
Figure 2:    Key Strategies Incorporated by Stakeholders of NGS Market, to Sustain the Compatation (from January 2014 to February 2019)
Figure 3:    Leading Service Providers in the Next-Generation Sequencing Market
Figure 4:    Global Next-Generation Sequencing Market, 2018-2024
Figure 5:    Global Next-Generation Sequencing Market Share (by Product), 2018 and 2024
Figure 6:    Global Next-Generation Sequencing Market Share (by Technology), 2018 and 2024
Figure 7:    Global Next-Generation Sequencing Market Share (by Application), 2018 and 2024
Figure 8:    Global Next-Generation Sequencing Market Share (by Region), 2018 and 2024
Figure 1.1:    Different steps in Next-Generation Sequencing Technology
Figure 1.2:    Evolution of Next-Generation Sequencers with Progress in Molecular Technologies
Figure 1.3:    Global Next-Generation Sequencing Market, 2018-2024
Figure 2.1:    Market Dynamics of Global NGS Market
Figure 3.1:    Competitive Landscape, January 2014-February 2019
Figure 3.2:    Share of Key Developments and Strategies, January 2014-February 2019
Figure 3.3:    Product Launch and Enhancements Share (by Companies), January 2014-February 2019
Figure 3.4:    Collaborations, Partnership, Joint Ventures, and Agreements Share (by Companies), January 2014-February 2019
Figure 3.5:    Mergers and Acquisitions Share (by Companies), January 2014-February 2019
Figure 3.6:    Business Expansion and Others Share (by Companies), January 2014-February 2019
Figure 3.7:    Market Share Analysis (by Companies) for the Global Next-Generation Sequencing Market, 2016 and 2017
Figure 3.8:    Market Share Analysis (by Companies) for the Global Next-Generation Sequencing Instruments Market, 2016 and 2017
Figure 3.9:    Market Share Analysis (by Companies) for the Global Next-Generation Sequencing Kits and Consumables Market, 2016 and 2017
Figure 3.10:    Growth Share Matrix for Global Next-Generation Sequencing Market (by Products), 2017
Figure 3.11:    Growth Share Matrix for Global Next-Generation Sequencing Market (by Sequencing Instruments Provider), 2017
Figure 3.12:    Key Entities of Value Chain
Figure 3.13:    Value Chain of Medical Device Industry
Figure 3.14:    Value Chain Analysis: Illumina, Inc.
Figure 3.15:    Cost Per Genome Sequencing ($) vs. Maximum Output of Sequencer Per Run
Figure 3.16:    Maximum Output per Run Required for $100 Genome Sequencing
Figure 4.1:    Level of NGS Service Providers Presence
Figure 5.1:    Global NGS Market (by Product Type)
Figure 5.2:    Global NGS Market (by Product Type), 2018 and 2024
Figure 5.3:    Pivotal Types of Instruments Associated with NGS
Figure 5.4:    Global NGS Instruments Market, 2018-2024
Figure 5.5:    Pivotal Types of Kits & Consumables Associated with NGS
Figure 5.6:    Global NGS Kits & Consumables Market, 2018-2024
Figure 5.7:    Key Entities of Supply Chain
Figure 5.8:    Comparison of MedTech Industry and Total Consumer Industry Supply Chain
Figure 5.9:    Supply Chain Model
Figure 5.10:    Different Types of Computational Platforms
Figure 5.11:    Global NGS Software Market, 2018-2024
Figure 6.1:    Different Types of Sequencing
Figure 6.2:    Global NGS Market (by Technology), 2018 and 2024
Figure 6.3:    Global NGS Market for Reversible Terminator Sequencing, 2018-2024
Figure 6.4:    Global NGS Market for Ion Torrent Semiconductor Sequencing, 2018-2024
Figure 6.5:    Global NGS Market for Single Molecule Real-Time Sequencing, 2018-2024
Figure 6.6:    Global NGS Market for Nanopore Sequencing Technology, 2018-2024
Figure 6.7:    Global NGS Market for Other Technologies, 2018-2024
Figure 7.1:    Leading Fields Which are Witnessing Colossal Incorporation of NGS
Figure 7.2:    Global NGS Market (by Application), 2018-2024
Figure 7.3:    Application of NGS in the field of Pharmaceuticals
Figure 7.4:    Global NGS Market for Pharmaceuticals Applications, 2018-2024
Figure 7.5:    Applications of NGS in the field of Diagnostics
Figure 7.6:    Global NGS Market for Diagnostics Applications, 2018-2024
Figure 7.7:    Global NGS Market for Agricultural and Animal Research Applications, 2018-2024
Figure 7.7:    Global NGS Market for Forensics Applications, 2018-2024
Figure 7.8:    Global NGS Market for Other Applications, 2018-2024
Figure 8.1:    Global Next-Generation Sequencing Market (by Region), 2018 and 2024
Figure 8.2:    North America: Next-Generation Sequencing Market, (2018-2024)
Figure 8.3:    North America: Market Dynamics
Figure 8.4:    Market Share Analysis: North America Sequencing Market, 2016 and 2017
Figure 8.5:    North America: Next-Generation Sequencing Market (by Country), 2018 and 2024
Figure 8.6:    The U.S.: Next-Generation Sequencing Market, 2018-2024
Figure 8.7:    Canada.: Next-Generation Sequencing Market, 2018-2024
Figure 8.8:    Europe: Next-Generation Sequencing Market, (2018-2024)
Figure 8.9:    Europe: Market Dynamics
Figure 8.10:    Market Share Analysis: Europe Sequencing Market, 2016 and 2017
Figure 8.11:    Europe: Next-Generation Sequencing Market (by Country), 2018 and 2024
Figure 8.12:    Germany: Next-Generation Sequencing Market, 2018-2024
Figure 8.13:    The U.K.: Next-Generation Sequencing Market, 2018-2024
Figure 8.14:    France: Next-Generation Sequencing Market, 2018-2024
Figure 8.15:    Italy: Next-Generation Sequencing Market, 2018-2024
Figure 8.16:    Spain: Next-Generation Sequencing Market, 2018-2024
Figure 8.17:    The Netherlands: Next-Generation Sequencing Market, 2018-2024
Figure 8.18:    Sweden: Next-Generation Sequencing Market, 2018-2024
Figure 8.19:    Denmark: Next-Generation Sequencing Market, 2018-2024
Figure 8.20:    Rest-of-Europe: Next-Generation Sequencing Market, 2018-2024
Figure 8.21:    Asia-Pacific: Next-Generation Sequencing Market, (2018-2024)
Figure 8.22:    Asia-Pacific: Market Dynamics
Figure 8.23:    Market Share Analysis: Asia-Pacific Sequencing Market, 2016 and 2017
Figure 8.24:    Asia-Pacific: Next-Generation Sequencing Market (by Country), 2018 and 2024
Figure 8.25:    China: Next-Generation Sequencing Market, 2018-2024
Figure 8.26:    Japan: Next-Generation Sequencing Market, 2018-2024
Figure 8.27:    Australia: Next-Generation Sequencing Market, 2018-2024
Figure 8.28:    India: Next-Generation Sequencing Market, 2018-2024
Figure 8.29:    South Korea: Next-Generation Sequencing Market, 2018-2024
Figure 8.30:    Singapore: Next-Generation Sequencing Market, 2018-2024
Figure 8.31:    Rest-of-the-Asia-Pacific: Next-Generation Sequencing Market, 2018-2024
Figure 8.32:    Latin America: Next-Generation Sequencing Market, (2018-2024)
Figure 8.33:    Latin America: Market Dynamics
Figure 8.34:    Market Share Analysis: Latin America Sequencing Market, 2016 and 2017
Figure 8.35:    Latin America: Next-Generation Sequencing Market (by Country), 2018 and 2024
Figure 8.36:    Brazil: Next-Generation Sequencing Market, 2018-2024
Figure 8.37:    Mexico: Next-Generation Sequencing Market, 2018-2024
Figure 8.38:    Rest-of-Latin America: Next-Generation Sequencing Market, 2018-2024
Figure 8.39:    Rest-of-the-World: Next-Generation Sequencing Market, 2018-2024
Figure 9.1:    Shares of Key Company Profiles
Figure 9.2:    10x Genomics Product Offerings for Global Next-Generation Sequencing Market
Figure 9.3:    10X Genomics: SWOT Analysis
Figure 9.4:    Agilent Technologies, Inc. Product Offerings for Global Next-Generation Sequencing Market
Figure 9.5:    Agilent Technologies, Inc.: Overall Financials, 2016-2018
Figure 9.6:    Agilent Technologies, Inc.: Revenue (by Segment), 2016-2018
Figure 9.7:    Agilent Technologies, Inc.: Revenue (by Region), 2016-2018
Figure 9.8:    Agilent Technologies, Inc.: R&D Expenditure, 2016-2018
Figure 9.9:    Agilent Technologies, Inc.: SWOT Analysis
Figure 9.10:    Bio-Rad Laboratories, Inc. Product Offerings for Global Next-Generation Sequencing Market
Figure 9.11:    Bio-Rad Laboratories, Inc.: Overall Financials, 2015-2017
Figure 9.12:    Bio-Rad Laboratories, Inc.: Revenue (by Segment), 2015-2017
Figure 9.13:    Bio-Rad Laboratories, Inc.: Revenue (by Region), 2015-2017
Figure 9.14:    Bio-Rad Laboratories, Inc.: R&D Expenditure, 2015-2017
Figure 9.15:    Bio-Rad Laboratories, Inc.: SWOT Analysis
Figure 9.16:    BGI Product Offerings for Global Next-Generation Sequencing Market
Figure 9.17:    BGI : SWOT Analysis
Figure 9.18:    bioMérieux SA Product Offerings for Global Next-Generation Sequencing Market
Figure 9.19:    bioMérieux S.A.: Overall Financials, 2015-2017
Figure 9.20:    bioMérieux S.A.: Revenue (by Segment), 2015-2017
Figure 9.21:    bioMérieux S.A.: Revenue (by Region), 2015-2017
Figure 9.22:    bioMérieux S.A.: R&D Expenditure, 2015-2017
Figure 9.23:    bioMérieux SA.: SWOT Analysis
Figure 9.24:    Danaher Corporation Product Offerings for Global Next-Generation Sequencing Market
Figure 9.25:    Danaher Corporation: Overall Financials, 2015-2017
Figure 9.26:    Danaher Corporation: Revenue (by Segment), 2015-2017
Figure 9.27:    Danaher Corporation: Revenue (by Region), 2015-2017
Figure 9.28:    Danaher Corporation: R&D Expenditure, 2015-2017
Figure 9.29:    Danaher Corporation: SWOT Analysis
Figure 9.30:    F. Hoffmann-La Roche AG Product Offerings for Global Next-Generation Sequencing Market
Figure 9.31:    F. Hoffmann-La Roche AG: Overall Financials, 2016-2018
Figure 9.32:    F. Hoffmann-La Roche AG: Revenue (by Segment), 2016-2018
Figure 9.33:    F. Hoffmann-La Roche AG: Revenue (by Region), 2016-2018
Figure 9.34:    F. Hoffmann-La Roche AG: R&D Expenditure, 2016-2018
Figure 9.35:    F. Hoffmann-La Roche AG: SWOT Analysis
Figure 9.36:    Illumina, Inc. Product Offerings for Global Next-Generation Sequencing Market
Figure 9.37:    Illumina, Inc.: Overall Financials, 2016-2018
Figure 9.38:    Illumina, Inc.: Revenue (by Segment), 2016-2018
Figure 9.39:    Illumina, Inc.: Revenue (by Region), 2016-2018
Figure 9.40:    Illumina, Inc.: R&D Expenditure, 2016-2018
Figure 9.41:    Illumina, Inc.: SWOT Analysis
Figure 9.42:    New England Biolabs, Inc Product Offerings for Global Next-Generation Sequencing Market
Figure 9.43:    New England Biolabs, Inc.: SWOT Analysis
Figure 9.44:    NuGEN Technologies, Inc Product Offerings for Global Next-Generation Sequencing Market
Figure 9.45:    NuGEN Technologies, Inc.: SWOT Analysis
Figure 9.46:    Oxford Nanopore Technologies Limited Product Offerings for Global Next-Generation Sequencing Market
Figure 9.47:    Oxford Nanopore Technologies Limited : SWOT Analysis
Figure 9.48:    Pacific Biosciences of California, Inc. Product Offerings for Global Next-Generation Sequencing Market
Figure 9.49:    Pacific Biosciences of California, Inc.: Overall Financials, 2015-2017
Figure 9.50:    Pacific Biosciences of California, Inc.: Net Revenue by Region, 2015-2017
Figure 9.51:    Pacific Biosciences of California, Inc.:R&D Expenditure 2015-2017
Figure 9.52:    Pacific Biosciences of California, Inc.: SWOT Analysis
Figure 9.53:    QIAGEN N.V.: Overall Product Portfolio
Figure 9.54:    QIAGEN N.V.: Overall Financials, 2015-2017
Figure 9.55:    QIAGEN N.V.: Revenue (by Segment), 2015-2017
Figure 9.56:    QIAGEN N.V.: Revenue (by Region), 2015-2017
Figure 9.57:    QIAGEN N.V.: R&D Expenditure, 2015-2017
Figure 9.58:    QIAGEN N.V.: SWOT Analysis
Figure 9.59:    PerkinElmer, Inc. Product Offerings for Global Next-Generation Sequencing Market
Figure 9.60:    PerkinElmer, Inc.: Overall Financials, 2015-2017
Figure 9.61:    PerkinElmer, Inc.: Net Revenue (by Segment), 2015-2017
Figure 9.62:    PerkinElmer, Inc.: Net Revenue (By Region), 2015-2017
Figure 9.63:    PerkinElmer, Inc.: Net Revenue (By Region), 2016-2018
Figure 9.64:    PerkinElmer, Inc.: SWOT Analysis
Figure 9.65:    Thermo Fisher Scientific: Overall Product Portfolio (NGS Market)
Figure 9.66:    Thermo Fisher Scientific: Overall Financials, 2015-2017
Figure 9.67:    Thermo Fisher Scientific: Revenue (by Segment), 2015-2017
Figure 9.68:    Thermo Fisher Scientific: Revenue (by Region), 2015-2017
Figure 9.69:    Thermo Fisher Scientific: R&D Expenditure, 2015-2017
Figure 9.70:    Thermo Fisher Scientific: SWOT Analysis
Figure 10.1:    Next-Generation Sequencing: Market Segmentation
Figure 10.2:    Next-Generation Sequencing Market Segmentation
Figure 10.3:    Primary Research
Figure 10.4:    Secondary Research
Figure 10.5:    Data Triangulation
Figure 10.6:    Top-down Approach (Segment-wise Analysis)
Figure 10.7:    Bottom-up Approach (Segment-wise Analysis)
Figure 10.8:    Assumptions and Limitations
Figure 10.9:    Considered Factors for Data Prediction and Modelling

In the past few years, genome of several species has been sequenced using the automated sanger sequencing. There have been limitations associated with the sanger sequencing, leading to the development of improved sequencing technologies that are capable of sequencing a large number of human genome and are also capable of addressing the problems that were initially hindering growth of the next-generation sequencing (NGS) market. Further, several research centres initiated the designing of the new sequencing technologies which would not require gels and would allow sequencing of a large number of samples in parallel. The three parallel technologies that were introduced in the early 21st century are Polonator, the Heliscope Single Molecule Sequencer Technology, and the Ion Semi-Conductor (Torrent Ion Sequencing).  Since the introduction of these technologies, several attempts were made in the past to generate efficient sequencing technologies that would rely on single molecules, excluding the need for amplification steps. The two promising such technologies are Pacific Single molecule real time (SMRT) DNA sequencing and nanopore DNA sequencing.  The advent of aforementioned technologies has unleased some novel methods which hold the potential to make the $100 genome dream a reality in the near future.  These high-throughput sequencing methods have introduced new fields in the industry, which include analysis of RNA transcript, personal genomics, ChiP-Seq (Chromatin Immunoprecipitation sequencing), and ChiP-chip (Chromatin Immunoprecipitation coupled to DNA microarray), among others.

NGS in the clinical setting requires infrastructure, such as storage and computer capacity, and also the personnel expertise required to comprehensively analyse and interpret the subsequent data.

In addition, the volume of the data needs to be managed skilfully to properly extract the clinically important functions in a robust and clear interface.

The purpose of the study is to gain a holistic view of the next-generation sequencing market in terms of various influencing factors, such as recent trends, technological advancements, and regulatory aspects of the market. The scope of this report is centred upon conducting a detailed study of the technologies allied with the next-generation sequencing market. The global next-generation sequencing market is segmented on the basis of four sections, namely product, technology, application and geography. The global market value was estimated using these four different approaches and was validated with one another. These segments are further segmented into several sub-segments to ease the market estimation and to gain an in-depth view of the market.

The global next-generation sequencing market was $4.93 billion in 2018 and is estimated to grow over $9.91 billion by 2024. The global next-generation sequencing market is expected to grow with a double-digit compound annual growth rate between the years 2019 and 2024. With substantial increase in the demand for genome mapping programs and diagnostics tests based on sequencing, the NGS market is expected to witness an impressive growth and promises to be a lucrative field for investment. In terms of products, the kits and consumables sub-segment dominated the global next-generation sequencing market in 2018. However, the software sub-segment is expected to witness the highest CAGR in the forecast period from 2019 to 2024.

The reversible terminator sequencing technology currently dominates the global NGS market. Nanopore technology is estimated to witness the highest CAGR in the forecast period.

And by application, presently, the pharmaceuticals field holds the largest share of the global next-generation sequencing market and is expected to grow at 13.22% CAGR in the forecast period from 2019 to 2024.  However, with the growing demand for non-invasive diagnostic procedures, the diagnostic field is expected to witness an impressive CAGR in the forecast period from 2019 to 2024. The global next-generation sequencing market is segmented by geographical regions into North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World (RoW). North America is the leading contributor to the global next-generation sequencing market and contributed to 48% of the global market values in 2018. However, Asia-Pacific is expected to grow at a CAGR of 17.25% in the forecast period 2019-2024. Moreover, the Asia Pacific market contributed approximately 18.95% of the total global market value in 2018.

A paradigm shift in the dynamics market is expected in 2023 with the introduction of portable technologies in full scale. The leading players in the market are taking necessary steps to tackle the shift in the dynamics and sustain in the competition. The global next-generation sequencing market is majorly dominated by the U.S. players. Companies belonging to the U.S., such as Illumina, Inc., and Thermo Fisher Scientific, contributed to more than 70% of the market value in 2018. The key players which have significant contributions to the NGS market are 10x Genomics, Agilent Technologies, Inc., bioMérieux SA, Bio-Rad Laboratories, Inc., Danaher Corporation, F. Hoffmann-La Roche AG, GenapSys, Inc., Illumina, Inc., New England Biolabs, Inc., NuGEN Technologies Inc., Oxford Nanopore Technologies Limited, Pacific Biosciences of California, Inc., PerkinElmer, Inc., QIAGEN, and Thermo Fisher Scientific, among others.

The field of service providers for sequencing tests and the applications based on genome sequencing are perceived to be a lucrative business across the globe. With the impressive rise in the demand for sequencing-based diagnostics applications, namely non-invasive prenatal testing, companion diagnostics, and liquid biopsy, the service providing companies have gained popularity and acceptance across the globe. Additionally, substantial investments are being made in bioinformatics startups and service providing companies. With the growing demand for genome mapping programs, a large pool of genomic data is being generated, and the key players of the market are seeking help from the bioinformatics startups to meet the market requirement. Service providing companies help in expanding the global reach of the key players of the market and also play a significant role in increasing the adoptability of sequencing technologies across the globe.

Some of the opportunities on which significant work is being carried out presently in the market are hybridization of technologies and development of portable technologies. The best sequencer is the one with the ability to sequence long reeds, in short run time and with great accuracy. The present available sequencers on the market possess any one of the mentioned features, but not all three. In spite of the substantial investments made by prominent companies to develop the instruments with the aforementioned features, it is not expected to be the reality at any time soon. Thus, the hybridization of available technologies, such as SMRT and reversible semiconductor sequencing technology, is acknowledged to be a promising approach to cater to the needs of the market.

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