Published Year: 2024
Global Liquid Biopsy Market - A Global and Regional Analysis: Focus on Offering, Usage, Workflow, Ci
The global liquid biopsy market was valued at $4,072.6 million in 2023 and is expected to...
Market Research Report
A quick peek into the report
Introduction of Non-Cancer Liquid Biopsy Testing Market
The global non-cancer liquid biopsy testing market, initially valued at $4,276.1 million in 2024, is projected to witness substantial growth, surging to $19,308.8 million by 2035, marking a remarkable compound annual growth rate (CAGR) of 14.30% over the period from 2025 to 2035.
The global non-cancer liquid biopsy testing market is being propelled by the rising burden of chronic diseases, from cardiovascular and neurological disorders to prenatal and transplant care, and the growing demand for minimally invasive, real-time diagnostics. By analyzing blood-based biomarkers, liquid biopsy enables early detection and dynamic monitoring across a spectrum of indications without the risks of traditional sampling procedures. Advances in next-generation sequencing and assay sensitivity, coupled with significant industry investment, have positioned liquid biopsy as the preferred approach for applications such as non-invasive prenatal testing, graft-rejection surveillance and infectious-disease detection. However, high capital and per-test costs, along with an uneven reimbursement environment, continue to challenge widespread adoption. Strategic localization of workflows in underserved regions, exemplified by in-country deployments of CE-marked platforms, offers a powerful opportunity to reduce turnaround times, lower costs and broaden access, paving the way for liquid biopsy to become a cornerstone of precision and preventive medicine worldwide.
Market Introduction
The global non-cancer liquid biopsy testing market is rapidly growing as biopharma and diagnostics companies extend minimally invasive, blood-based molecular assays beyond oncology into critical areas such as prenatal screening, transplant surveillance and infectious?disease detection. By leveraging cell-free DNA, microRNAs and exosomes, liquid biopsy tests such as Illumina’s Verifi, Natera’s Panorama and Karius’ Spectrum, deliver early, real-time insights that traditionally required risky tissue sampling, improving patient safety and operational efficiency. Ongoing assay innovations and novel biomarker validations, combined with strategic partnerships, and targeted acquisitions, are localizing advanced workflows and reducing turnaround times, costs and logistical hurdles. As healthcare systems worldwide embrace precision and preventive medicine, the convergence of enhanced performance, regulatory compliance and digital?health integration positions non-cancer liquid biopsy as a cornerstone of next-generation diagnostics.
Industrial Impact
The non-cancer liquid biopsy testing market is witnessing rapid industrialization as key players leverage strategic alliances, targeted acquisitions, and significant funding to embed advanced, minimally invasive workflows within regional healthcare ecosystems. By partnering with digital-health providers and local laboratories, companies are streamlining end-to-end diagnostic pathways, slashing turnaround times and reducing per-test costs without compromising sample integrity. Simultaneously, mergers and geographic expansions are strengthening in-country capacities, while portfolio enhancements and new product launches are broadening application scopes, from prenatal and transplant monitoring to infectious-disease detection. Substantial capital inflows have accelerated R&D and commercialization, enabling assay standardization and regulatory compliance at scale. Together, these industrial dynamics are transforming non-cancer liquid biopsy from a niche innovation into a robust, globally accessible platform for precision and preventive medicine.
Market Segmentation:
Segmentation 1: by Application
• Prenatal Testing
• Organ Transplantation
• Others
Prenatal Testing Segment to Dominate the Non-Cancer Liquid Biopsy Testing Market (by Application)
The global non-cancer liquid biopsy testing market (by application) has been dominated by prenatal testing, representing 79.70% of the market share in 2024, and is expected to maintain its dominance during the forecast period. This reflects prenatal testing’s minimally invasive, single-blood-draw protocol with no risk, broad reimbursement coverage and universal guideline endorsements. These factors collectively support the growth of the prenatal testing in the non-cancer liquid biopsy space
Segmentation 2: Technology
• NGS
• PCR
• Others
NGS to Dominate the Non-Cancer Liquid Biopsy Testing Market (by Technology)
The global non-cancer liquid biopsy testing market (by technology) has been dominated by NGS, representing 59.68% of the market share in 2024, and is expected to maintain its dominance during the forecast period due to its unparalleled capacity for comprehensive, high-throughput genomic profiling in a single assay and its steadily declining per-sample costs enabled by technological advances and scale efficiencies.
Segmentation 3: by End User
• Clinical
• Research
Clinical to Dominate the Non-Cancer Liquid Biopsy Testing Market (by End User)
The global non-cancer liquid biopsy testing market (by end user) has been dominated by clinical segment, representing 86.22% of the market share in 2024, and is expected to maintain its dominance during the forecast period driven by rapid adoption of liquid biopsy in clinical laboratories and increasing utilization by pharmaceutical and biotech companies for drug development and clinical trial monitoring. This dominance reflects strong reimbursement pathways, integration into routine patient care and the escalating demand for minimally invasive diagnostics in both clinical practice and therapeutic innovation.
Segmentation 4: by Region
• North America
o U.S.
o Canada
• Europe
o U.K.
o France
o Germany
o Italy
o Spain
o Rest-of-Europe
• Asia-Pacific
o Japan
o China
o India
o Australia
o Rest-of-Asia-Pacific
• Latin America
o Brazil
o Mexico
o Rest-of-Latin America
• Middle East and Africa
o U.A.E.
o K.S.A.
o South Africa
o Rest-of-Middle East and Africa
The non-cancer liquid biopsy testing market in the Asia-Pacific region is expected to witness a significant growth rate of 15.77% during the forecast period.
Recent Developments
• In May 2025, BillionToOne, Inc. launched an expanded UNITY Fetal Risk Screen to assess fetal risk for up to 14 genetic conditions from a single blood sample as early as nine weeks into pregnancy.
• In Febrauary 2025, Yourgene Health launched IONA Care+, a comprehensive non-invasive prenatal testing (NIPT) service in the U.K. This service utilizes the IONA Nx NIPT Workflow to provide accurate screening for genetic conditions, including microdeletions.
• In Febrauary 2025, Acrannolife Genomics partnered with GOQii to launch a program aimed at enhancing post-transplant care in India through advanced digital and genomic solutions.
Demand – Drivers, Challenges, and Opportunities
Market Drivers:
Growing Disease Burden and Screening: The global non-cancer liquid biopsy testing market is witnessing growth due to the rising burden of chronic diseases and the need for non-invasive diagnostic tools. Liquid biopsy enables early detection and monitoring of conditions like cardiovascular and neurological disorders by analyzing biomarkers such as cfDNA and circulating/exosomal miRNAs. It offers real-time disease insights, particularly where traditional tissue biopsies are difficult. Beyond heart and brain health, it also supports applications in organ transplantation, prenatal testing, and infectious disease management.
Market Challenges:
Uncertain Reimbursement Landscape and High Setup Costs Hindering Widespread Adoption: The adoption of non-cancer liquid biopsy tests is limited by an uncertain and inconsistent reimbursement landscape, especially outside oncology applications. Despite their clinical potential, payers demand stronger evidence of cost-effectiveness, and rapid technological advancements often outpace policy updates. High setup costs for advanced sequencing platforms and expensive per-test pricing further restrict access, especially without insurance coverage. These challenges hinder widespread clinical integration, particularly in prenatal, infectious disease, and transplant-related diagnostics.
Market Opportunities:
Expanding Access in Underserved Regions: Non-cancer liquid biopsy companies are localizing advanced diagnostic services in underserved regions to improve access and reduce reliance on overseas labs. By implementing in-house workflows, such as Yourgene Health’s NIPT solutions in Morocco and Colombia, they’ve reduced turnaround times, costs, and test failures. These efforts enable faster, more accurate diagnoses while enhancing clinical autonomy. This approach presents a scalable opportunity for wider adoption across prenatal, transplant, and infectious disease diagnostics, promoting health equity and deeper market penetration.
Analyst’s Thoughts
According to Akash Mhaskar, Principal Analyst – BIS Research, “The global non-cancer liquid biopsy testing market is gaining strong momentum as healthcare shifts toward early, non-invasive, and personalized diagnostics. Continued innovation, clinical validation, and strategic localization are expected to drive broader adoption across prenatal, transplant, and infectious disease applications.”
Non-Cancer Liquid Biopsy Testing Market - A Global and Regional Analysis
Focus on Application, Technology, End User, and Regional Analysis - Analysis and Forecast, 2025-2035
Some Faq's
Frequently Asked Questions
The non-cancer liquid biopsy testing market comprises non-invasive or minimally invasive liquid biopsy testing, primarily through the analysis of blood, to detect and monitor a range of non-oncological conditions. These include prenatal genetic abnormalities, infectious diseases, organ transplant monitoring, and several other indications. By offering faster, safer, and more accessible alternatives to traditional invasive counterparts, non-cancer liquid biopsy testing supports early diagnosis, real-time disease monitoring, and improved clinical decision-making across healthcare settings.
Existing market players are adopting a range of strategies to strengthen their competitive position. These include launching advanced and expanded testing solutions to diversify their product portfolios, forming strategic partnerships to enhance regional access and streamline service delivery, securing substantial funding to support R&D and market expansion, and pursuing mergers and acquisitions to broaden their geographical presence and operational capacity. Such initiatives are enabling companies to meet growing demand, improve turnaround times, and deliver localized, high-quality diagnostic solutions.
The following are the USPs of this report:
• Market regulations and key trends in the non-cancer liquid biopsy testing market
• Market dynamic analysis of the opportunities, trends, and challenges in the market
• Country-wise testing volumes for the non-cancer liquid biopsy tests
The global non-cancer liquid biopsy testing market report is ideal for diagnostic companies and investors seeking to understand market trends, growth opportunities, and strategic developments. It also benefits digital health firms, research institutions, and consultants aiming to support innovation and adoption in precision diagnostics.
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