Phosphoramidite Market - A Global and Country Level Analysis

Focus on Type, End User, and Region - Analysis and Forecast, 2022-2032

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Market Report Coverage

Phosphoramidite Market
Forecast Period: 2022-2032
CAGR During Forecast Period: 7.78%

Phosphoramidite Market

Base Year

2021

Market Size in 2021

$900.3 Million

Forecast Period

2022-2032

Value Projection and Estimation by 2032

$2,062.9 Million

CAGR During Forecast Period

7.78%

Number of Tables

6

Number of Pages

126

Number of Figures

97

 

Key Market Players and Competition Synopsis

The companies that are profiled have been selected based on inputs gathered from primary experts and analyzing the company’s coverage, product portfolio, and market penetration.

Some of the prominent names in this market are:

•    Biosynth Carbosynth
•    Bioneer Corporation
•    Lumiprobe Corporation
•    QIAGEN N.V.
•    Danaher Corporation (IDT)
•    TriLink BioTechnologies
•    Creative Biolabs
•    PolyOrg, Inc.
•    Hongene Biotech Corporation
•    ChemGenes
•    BOC Sciences
•    Tokyo Chemical Industry Co., Ltd. (TCI)
•    LGC Science Group Holdings Limited
•    AAT Bioquest, Inc.
•    Thermo Fisher Scientific, Inc.
•    Merck KGaA

How can this report add value to an organization?

The report can help the reader gain a holistic view of the current and future global phosphoramidite market

Innovation Strategy: The global phosphoramidite report can help the reader gain a holistic view of the current and future global phosphoramidite market, including the competitive landscape, market size, and factors impacting the industry.

Growth/Marketing Strategy: The global phosphoramidite market has seen major development by key players operating in the market, such as acquisitions, business expansion and funding, and other developments. The favored strategy for the companies has been business expansion activities along with acquisitions to strengthen their position in the market.

Competitive Strategy: Key players in the global phosphoramidite market have been analyzed and profiled in the study. Moreover, a detailed competitive benchmarking of players operating in the global phosphoramidite market has been done to help the reader understand how players stack against each other, presenting a clear market landscape. Additionally, comprehensive competitive strategies such as partnerships, agreements, and collaborations will aid the reader in understanding the untapped revenue pockets in the market.

Industry and Technology Overview

The global phosphoramidite market is projected to reach $2,062.9 million by 2032 from $900.3 million in 2021.

Global Phosphoramidite Market: Industry Overview

The global phosphoramidite market is projected to reach $2,062.9 million by 2032 from $900.3 million in 2021, at a CAGR of 7.78% during the forecast period 2022-2032. The market growth can be ascribed to the rising demand for oligonucleotides, growing synthetic biology market, increasing partnerships and collaborations, continuous investment for research and development activities by private and public firms, and growing prevalence of several diseases creating an urgent need for novel therapeutic treatments.

Market Lifecycle Stage

The global phosphoramidite market is in the rapidly evolving and dynamic stage, which opens ample opportunities for life sciences companies. Also, companies that are already in the development phase for phosphoramidite are trying to bring diverse manufacturing options to the market to improve the quality of oligonucleotides. The companies operating in the global phosphoramidite market are now focusing more on high-quality and customized options. Also, major players such as Merck KGaA, Maravai LifeSciences Holdings, Inc, LGC Science Group Holdings Limited, and Thermo Fisher Scientific Inc. are investing heavily in research and development for their respective phosphoramidite products.

Figure: Global Phosphoramidite Market Snapshot

Phosphoramidite Market

Source: BIS Research Analysis

Impact

Before the discovery of phosphoramidites in 1981, deoxyribonucleic acid (DNA) synthesis techniques were restricted in the quality of DNA produced. Inefficient reactions generated truncated oligonucleotide sequences. Additionally, intermediates utilized in the synthesis process were highly unstable, predisposing the growing oligonucleotide sequence to damage. Together, several characteristics of phosphoramidites have enabled the chemistry to work well for a long time. Phosphoramidite chemistry is of fundamental importance for producing synthetic oligonucleotides that can be further utilized in a range of different areas, for instance, as primers for a polymerase chain reaction, oligonucleotide-based therapies, and genetic engineering. Millions of synthetic oligonucleotides are employed in research laboratories, pharmaceutical industries, and hospitals.

The phosphoramidite chemistry is unlikely to be replaced by emerging technologies, as the demand for primers and short-length DNA sequences is burgeoning within pharmaceuticals, synthetic biology, and molecular diagnostic industries. Essentially, synthetic DNA is applied for the discovery and engineering of biological pathways, making DNA synthesis a breakthrough of the last century. Thus, the market is anticipated to grow significantly during the forecast period 2022-2032. 

Market Segmentation

Segmentation 1: by Type
•    DNA Phosphoramidites
•    RNA Phosphoramidites
•    Labeled Phosphoramidites
•    Others

Growing research and development activities and demand within the synthetic biology, pharmaceutical, diagnostic, and other industries are increasing the adoption of DNA phosphoramidites. Therefore, the type segment is dominated by DNA phosphoramidites, which held a share of 74.30% in 2021.

Segmentation 2: by End User
•    Pharmaceutical and Biotechnology Companies
•    Diagnostic Laboratories
•    Synthetic Biology and Research Institutes

Among all three segments of end users, the pharmaceutical and biotechnology companies segment accounted for the largest share, holding 47.50% of the market in 2021.

Segmentation 3: by Region
•    North America
•    Europe
•    Asia-Pacific
•    Rest-of-the-World

North America is expected to dominate the global phosphoramidite market during the forecast period 2022-2032.

Recent Developments in the Global Phosphoramidite Market

•    In August 2019, the company acquired 75% ordinary capital of the parent company of Toronto Research Chemicals Inc., i.e., Biomed Pharmaceutical Limited.
•    In July 2022, TriLink BioTechnologies expanded its R&D leadership team's responsibility for leading the company’s scientific direction and research and development strategy.
•    In May 2022, TriLink BioTechnologies announced a cooperative agreement with the Department of Defense and included funding for TriLink’s expansion in San Diego, California, for nucleic acid production.
•    In November 2021, Biosynth Carbosynth acquired Kexing Biopharmaceutical Co., Ltd.’s raw material manufacturing unit located in Jinan, China, to expand its operations and deliver a wide range of products at a larger production volume and increased capacity. The facility extends to more than 30,000 square meters of area.
•    In November 2021, a leading investment firm, KKR, invested an undisclosed amount and acquired Biosynth Carbosynth from its founders, Armira and Dr. Urs Spitz. However, senior management will retain a significant ownership stake, and KKR will contribute as a strategic partner. KKR plans to encourage and accelerate the company's product portfolio expansion and geographic buildout and widen its capabilities.

Demand - Drivers and Limitations

Following are the demand drivers for the global phosphoramidite market:

•    Increasing Synthetic Nucleotide Applications in Therapeutics
•    Growth in Synthetic Biology

The market is expected to face some limitations due to the following challenges:

•    Challenges in Developing Long Nucleotide Sequences
•    Competition from Emerging DNA Synthesis Technologies

Analyst Perspective

According to Sara Virmani, Senior Research Analyst, BIS Research, “Growing research and development activities and demand within the synthetic biology, pharmaceutical, diagnostic, and other industries are increasing the adoption of DNA and RNA-based phosphoramidites. In addition, the increased flow of investments from private and public firms, the emergence of start-ups, and the rising number of partnerships coupled with mergers and acquisitions are fuelling the market growth.”

Table of Contents

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1.1    Product Definition
1.2    Inclusion and Exclusion

2.1    Key Questions Answered in the Report

3.1    Data Sources
         3.1.1    Primary Data Source
         3.1.2    Secondary Data Sources
3.2    Market Estimation Model
3.3    Criteria for Company Profiling

4.1    Introduction
4.2    Phosphoramidite Synthesis Process
         4.2.1    Stability Considerations for Phosphoramidite
4.3    Applications of Phosphoramidite Chemistry
4.4    Future Trends in Phosphoramidite Industry
4.5    COVID-19 Impact on Phosphoramidite Industry
4.6    Current Market Size and Growth Potential, $Million, 2022-2032

5.1    Overview
5.2    Regulatory Considerations for Phosphoramidite
         5.2.1    Challenges
         5.2.2    Current Regulatory Landscape
         5.2.3    GMP, Control Strategy, and Facility Considerations
                     5.2.3.1    Brief Control Strategy

6.1    Overview
6.2    Impact Analysis
6.3    Market Drivers
         6.3.1    Increasing Synthetic Nucleotide Applications in Therapeutics
         6.3.2    Growth in Synthetic Biology
6.4    Market Restraints
         6.4.1    Challenges in Developing Long Nucleotide Sequences
         6.4.2    Competition from Emerging DNA Synthesis Technologies
6.5    Market Opportunities
         6.5.1    Utilize advanced tools for lowering manufacturing cost and increasing production in gene synthesis

7.1    Overview
7.2    DNA Phosphoramidites
7.3    RNA Phosphoramidites
7.4    Labeled Phosphoramidites
7.5    Other Phosphoramidites

8.1    Overview
8.2    Pharmaceutical and Biotechnology Companies
8.3    Diagnostic Laboratories
8.4    Synthetic Biology and Research Institutes

9.1    Overview
9.2    North America
         9.2.1    U.S.
         9.2.2    Canada
9.3    Europe
         9.3.1    U.K.
         9.3.2    Germany
         9.3.3    France
         9.3.4    Spain
         9.3.5    Italy
         9.3.6    Rest-of-Europe
9.4    Asia-Pacific
         9.4.1    Japan
         9.4.2    China
         9.4.3    India
         9.4.4    Rest-of-Asia-Pacific
9.5    Rest-of-the-World

10.1    Key Strategies and Development
           10.1.1    Overview
           10.1.2    Business Expansions
           10.1.3    Mergers and Acquisitions
           10.1.4    Funding Activities
           10.1.5    Others
10.2    Market Share Analysis (by Company) 2021

11.1    Overview
11.2    Biosynth Carbosynth
           11.2.1    Company Overview
           11.2.2    Role of Biosynth Carbosynth in the Global Phosphoramidite Market    
           11.2.3    Key Competitors of the Company
           11.2.4    Corporate strategies
                        11.2.4.1    Synergistic Activities
           11.2.5    Analyst Perspective
11.3    Bioneer Corporation
           11.3.1    Company Overview
           11.3.2    Role of Bioneer Corporation in the Global Phosphoramidite Market    
           11.3.3    Key Competitors of the Company
           11.3.4    Analyst Perspective
11.4    Lumiprobe Corporation
           11.4.1    Company Overview
           11.4.2    Role of Lumiprobe Corporation in the Global Phosphoramidite Market
           11.4.3    Key Competitors of the Company
           11.4.4    Analyst Perspective
11.5    QIAGEN N.V.
           11.5.1    Company Overview
           11.5.2    Role of QIAGEN N.V. in the Global Phosphoramidite Market
           11.5.3    Key Competitors of the Company
           11.5.4    Financials
           11.5.5    Analyst Perspective
11.6    Danaher Corporation (IDT)
           11.6.1    Company Overview
           11.6.2    Role of Danaher Corporation (IDT) in the Global Phosphoramidite Market
           11.6.3    Key Competitors of the Company
           11.6.4    Key Customers of the Company
           11.6.5    Financials
           11.6.6    Analyst Perspective
11.7    TriLink BioTechnologies
           11.7.1    Company Overview
           11.7.2    Role of TriLink BioTechnologies in the Global Phosphoramidite Market
           11.7.3    Key Competitors of the Company
           11.7.4    Financials
           11.7.5    Business Strategies
           11.7.6    Analyst Perspective
11.8    Creative Biolabs
           11.8.1    Company Overview
           11.8.2    Role of Creative Biolabs in the Global Phosphoramidite Market
           11.8.3    Key Competitors of the Company
11.9    PolyOrg, Inc.
           11.9.1    Company Overview
           11.9.2    Role of PolyOrg, Inc. in the Global Phosphoramidite Market
           11.9.3    Key Competitors of the Company
11.10    Hongene Biotech Corporation
             11.10.1    Company Overview
             11.10.2    Role of Hongene Biotech Corporation in the Global Phosphoramidite Market
             11.10.3    Key Competitors of the Company
             11.10.4    Business Strategies
11.11    ChemGenes
             11.11.1    Company Overview
             11.11.2    Role of ChemGenes in the Global Phosphoramidite Market
             11.11.3    Key Competitors of the Company
11.12    BOC Sciences
             11.12.1    Company Overview
             11.12.2    Role of BOC Sciences in the Global Phosphoramidite Market
             11.12.3    Key Competitors of the Company
             11.12.4    Key Customers of the Company
11.13    Tokyo Chemical Industry Co., Ltd. (TCI)
             11.13.1    Company Overview
             11.13.2    Role of Tokyo Chemical Industry Co., Ltd. in the Global Phosphoramidite Market
             11.13.3    Key Competitors of the Company
11.14    LGC Science Group Holdings Limited
             11.14.1    Company Overview
             11.14.2    Role of LGC Science Group Holdings Limited in the Global Phosphoramidite Market
             11.14.3    Key Competitors of the Company
             11.14.4    Key Customers of the Company
             11.14.5    Financials
             11.14.6    Business Strategies
             11.14.7    Analyst Perspective
11.15    AAT Bioquest, Inc.
             11.15.1    Company Overview
             11.15.2    Role of AAT Bioquest, Inc. in the Global Phosphoramidite Market
             11.15.3    Key Competitors of the Company
11.16    Thermo Fisher Scientific, Inc.
             11.16.1    Company Overview
             11.16.2    Role of Thermo Fisher Scientific, Inc. in the Global Phosphoramidite Market
             11.16.3    Key Competitors of the Company
             11.16.4    Financials
             11.16.5    Analyst Perspective
11.17    Merck KGaA
             11.17.1    Company Overview
             11.17.2    Role of Merck KGaA in the Global Phosphoramidite Market
             11.17.3    Key Competitors of the Company
             11.17.4    Financials
             11.17.5    Analyst Perspective

Table 1:    Companies and COVID-19 Impact
Table 2:    Guideline Summary for Phosphoramidites
Table 3:    Decreased Coupling Efficiency with Extending Oligonucleotide Sequence
Table 4:    Key Characteristics of Enzymatic-based and Phosphoramidite Synthesis
Table 5:    Examples of RNA Phosphoramidites
Table 6:    List of Approved Oligonucleotide-Based Therapies, 1998-2020

Figure 1:    Global Phosphoramidite Market Dynamics
Figure 2:    Global Phosphoramidite Market (by Type), $Million, 2021 and 2032
Figure 3:    Global Phosphoramidite Market (by End User), $Million, 2021 and 2032
Figure 4:    Global Phosphoramidite Market (by Region), $Million, 2021-2032
Figure 5:    Global Phosphoramidite Market Segmentation
Figure 6:    Global Phosphoramidite Market Research Methodology
Figure 7:    Primary Research Methodology
Figure 8:    Volume-Based Market Sizing and Forecasting Methodology
Figure 9:    Structure of a Standard 2’-Deoxyadenosine Phosphoramidite
Figure 10:    Workflow of Phosphoramdite Synthesis Chemistry to Produce Oligonucleotides
Figure 11:    Phosphoramidite Synthesis Cycle
Figure 12:    Factors Impacting the Stability of Phosphoramidites
Figure 13:    Phosphoramidite Key Application Areas
Figure 14:    Global Phosphoramidite Market, $Million, 2021-2032
Figure 15:    Challenges for Phosphoramidite as a Drug Product
Figure 16:    Control Strategy: Phosphoramidite Elements
Figure 17:    Elements of Microbial Control Strategy
Figure 18:    Details of GMP, Control Strategy, and Facility Considerations
Figure 19:    Market Dynamics
Figure 20:    Impact Analysis
Figure 21:    Factors Influencing Rise in Oligonucleotide Demand and Growing Market
Figure 22:    Breakthrough Achievements in Synthetic Biology, 2016-2020
Figure 23:    Key Competitors Impacting Global Phosphoramidite Market Growth in Future
Figure 24:    Share of Global Phosphoramidite Market (by Type), $Million, 2021 and 2032
Figure 25:    Characteristics of DNA Phosphoramidites
Figure 26:    Global Phosphoramidite Market (DNA Phosphoramidites), $Million, 2021-2032
Figure 27:    Global Phosphoramidite Market (RNA Phosphoramidites), $Million, 2021-2032
Figure 28:    Global Phosphoramidite Market (Labeled Phosphoramidites), $Million, 2021-2032
Figure 29:    Global Phosphoramidite Market (Other Phosphoramidites), $Million, 2021-2032
Figure 30:    Share of Global Phosphoramidite Market (by End User), $Million, 2021 and 2032
Figure 31:    Global Phosphoramidite Market (Pharmaceutical and Biotechnology Companies), $Million, 2021-2032
Figure 32:    Global Phosphoramidite Market (Diagnostic Laboratories), $Million, 2021-2032
Figure 33:    Global Phosphoramidite Market (Synthetic Biology and Research Institutes), $Million, 2021-2032
Figure 34:    Global Phosphoramidite Market (by Region), $Million, 2021-2032
Figure 35:    Market Dynamics of North America Phosphoramidite Market
Figure 36:    North America Phosphoramidite Market, $Million, 2021-2032
Figure 37:    Projections of the Older Adult Population in the U.S.: 2016 to 2060 (Million)
Figure 38:    U.S. Phosphoramidite Market, $Million, 2021-2032
Figure 39:    Canada Phosphoramidite Market, $Million, 2021-2032
Figure 40:    Market Dynamics of Europe Phosphoramidite Market
Figure 41:    Europe Phosphoramidite Market, $Million, 2021-2032
Figure 42:    U.K. Phosphoramidite Market, $Million, 2021-2032
Figure 43:    Germany Phosphoramidite Market, $Million, 2021-2032
Figure 44:    France Phosphoramidite Market, $Million, 2021-2032
Figure 45:    Spain Phosphoramidite Market, $Million, 2021-2032
Figure 46:    Italy Phosphoramidite Market, $Million, 2021-2032
Figure 47:    Rest-of-Europe Phosphoramidite Market, $Million, 2021-2032
Figure 48:    Market Dynamics of the Asia-Pacific Phosphoramidite Market
Figure 49:    Asia-Pacific Phosphoramidite Market, $Million, 2021-2032
Figure 50:    Japan Phosphoramidite Market, $Million, 2021-2032
Figure 51:    China Phosphoramidite Market, $Million, 2021-2032
Figure 52:    India Phosphoramidite Market, $Million, 2021-2032
Figure 53:    Rest-of-APAC Phosphoramidite Market, $Million, 2021-2032
Figure 54:    Rest-of-the-World Phosphoramidite Market, $Million, 2021-2032
Figure 55:    Figure: Share of Key Developments, January 2019-August 2022
Figure 56:    Business Expansions (by Company), January 2019-August 2022
Figure 57:    Merger and Acquisition Activities (by Company), January 2019-August 2022
Figure 58:    Market Share Analysis for the Global Phosphoramidite Market, 2021
Figure 59:    Total Number of Companies Profiled
Figure 60:    Bioneer Corporation’s Phosphoramidite Manufacturing Capacity
Figure 61:    Bioneer Corporation: Selective Product Portfolio
Figure 62:    Lumiprobe Corporation: Selective Product Portfolio
Figure 63:    QIAGEN N.V.: Selective Product Profile
Figure 64:    QIAGEN N.V.: Overall Financials, 2019-2021
Figure 65:    QIAGEN N.V.: Revenue (by Segment), $Million, 2019-2021
Figure 66:    QIAGEN N.V.: Revenue (by Region), $Million, 2019-2021
Figure 67:    QIAGEN N.V.: R&D Expenditure, 2019-2021
Figure 68:    Danaher Corporation (IDT): Selective Product Portfolio
Figure 69:    Danaher Corporation (IDT): Overall Financials, $Million, 2019-2021
Figure 70:    Danaher Corporation (IDT): Revenue (by Segment), $Million, 2019-2021
Figure 71:    Danaher Corporation (IDT): Revenue (by Region), $Million, 2019-2021
Figure 72:    Danaher Corporation (IDT), R&D Expenditure, $Million, 2019-2021
Figure 73:    TriLink BioTechnologies: Selective Product Portfolio
Figure 74:    Maravai LifeSciences Holdings, Inc.: Overall Financials, $Million, 2019-2021
Figure 75:    Maravai LifeSciences Holdings, Inc.: Revenue (by Segment), $Million, 2019-2021
Figure 76:    Maravai LifeSciences Holdings, Inc.: Revenue (by Region), $Million, 2019-2021
Figure 77:    Maravai LifeSciences Holdings, Inc.: R&D Expenditure, $Million, 2019-2021
Figure 78:    Creative Biolabs: Selective Product Portfolio
Figure 79:    PolyOrg, Inc.: Selective Product Portfolio
Figure 80:    Hongene Biotech Corporation: Selective Product Portfolio
Figure 81:    ChemGenes: Selective Product Portfolio
Figure 82:    BOC Sciences: Selective Product Portfolio
Figure 83:    Tokyo Chemical Industry Co., Ltd.: Selective Product Portfolio
Figure 84:    LGC Science Group Holdings Limited: Selective Product Portfolio
Figure 85:    LGC Science Group Holdings Limited: Overall Financials, $Million, 2019-2021
Figure 86:    LGC Science Group Holdings Limited: Revenue (by Region), $Million, 2019-2021
Figure 87:    AAT Bioquest, Inc.: Selective Product Portfolio
Figure 88:    Thermo Fisher Scientific, Inc.: Selective Product Portfolio
Figure 89:    Thermo Fisher Scientific, Inc.: Overall Financials, 2019-2021
Figure 90:    Thermo Fisher Scientific, Inc.: Revenue (by Segment), $Million, 2019-2021
Figure 91:    Thermo Fisher Scientific, Inc.: Revenue (by Region), $Million, 2019-2021
Figure 92:    Thermo Fisher Scientific, Inc.: R&D Expenditure, $Million, 2019-2021
Figure 93:    Merck KGaA: Selective Product Portfolio
Figure 94:    Merck KGaA: Overall Financials, $Million, 2019-2021
Figure 95:    Merck KGaA: Revenue (by Segment), $Million, 2019-2021
Figure 96:    Merck KGaA: Revenue (by Region), $Million, 2019-2021
Figure 97:    Merck KGaA: R&D Expenditure, $Million, 2019-2021

Market Report Coverage

Phosphoramidite Market

Base Year

2021

Market Size in 2021

$900.3 Million

Forecast Period

2022-2032

Value Projection and Estimation by 2032

$2,062.9 Million

CAGR During Forecast Period

7.78%

Number of Tables

6

Number of Pages

126

Number of Figures

97

 

Key Market Players and Competition Synopsis

The companies that are profiled have been selected based on inputs gathered from primary experts and analyzing the company’s coverage, product portfolio, and market penetration.

Some of the prominent names in this market are:

•    Biosynth Carbosynth
•    Bioneer Corporation
•    Lumiprobe Corporation
•    QIAGEN N.V.
•    Danaher Corporation (IDT)
•    TriLink BioTechnologies
•    Creative Biolabs
•    PolyOrg, Inc.
•    Hongene Biotech Corporation
•    ChemGenes
•    BOC Sciences
•    Tokyo Chemical Industry Co., Ltd. (TCI)
•    LGC Science Group Holdings Limited
•    AAT Bioquest, Inc.
•    Thermo Fisher Scientific, Inc.
•    Merck KGaA

How can this report add value to an organization?

Innovation Strategy: The global phosphoramidite report can help the reader gain a holistic view of the current and future global phosphoramidite market, including the competitive landscape, market size, and factors impacting the industry.

Growth/Marketing Strategy: The global phosphoramidite market has seen major development by key players operating in the market, such as acquisitions, business expansion and funding, and other developments. The favored strategy for the companies has been business expansion activities along with acquisitions to strengthen their position in the market.

Competitive Strategy: Key players in the global phosphoramidite market have been analyzed and profiled in the study. Moreover, a detailed competitive benchmarking of players operating in the global phosphoramidite market has been done to help the reader understand how players stack against each other, presenting a clear market landscape. Additionally, comprehensive competitive strategies such as partnerships, agreements, and collaborations will aid the reader in understanding the untapped revenue pockets in the market.

Industry and Technology Overview

Global Phosphoramidite Market: Industry Overview

The global phosphoramidite market is projected to reach $2,062.9 million by 2032 from $900.3 million in 2021, at a CAGR of 7.78% during the forecast period 2022-2032. The market growth can be ascribed to the rising demand for oligonucleotides, growing synthetic biology market, increasing partnerships and collaborations, continuous investment for research and development activities by private and public firms, and growing prevalence of several diseases creating an urgent need for novel therapeutic treatments.

Market Lifecycle Stage

The global phosphoramidite market is in the rapidly evolving and dynamic stage, which opens ample opportunities for life sciences companies. Also, companies that are already in the development phase for phosphoramidite are trying to bring diverse manufacturing options to the market to improve the quality of oligonucleotides. The companies operating in the global phosphoramidite market are now focusing more on high-quality and customized options. Also, major players such as Merck KGaA, Maravai LifeSciences Holdings, Inc, LGC Science Group Holdings Limited, and Thermo Fisher Scientific Inc. are investing heavily in research and development for their respective phosphoramidite products.

Figure: Global Phosphoramidite Market Snapshot

Phosphoramidite Market

Source: BIS Research Analysis

Impact

Before the discovery of phosphoramidites in 1981, deoxyribonucleic acid (DNA) synthesis techniques were restricted in the quality of DNA produced. Inefficient reactions generated truncated oligonucleotide sequences. Additionally, intermediates utilized in the synthesis process were highly unstable, predisposing the growing oligonucleotide sequence to damage. Together, several characteristics of phosphoramidites have enabled the chemistry to work well for a long time. Phosphoramidite chemistry is of fundamental importance for producing synthetic oligonucleotides that can be further utilized in a range of different areas, for instance, as primers for a polymerase chain reaction, oligonucleotide-based therapies, and genetic engineering. Millions of synthetic oligonucleotides are employed in research laboratories, pharmaceutical industries, and hospitals.

The phosphoramidite chemistry is unlikely to be replaced by emerging technologies, as the demand for primers and short-length DNA sequences is burgeoning within pharmaceuticals, synthetic biology, and molecular diagnostic industries. Essentially, synthetic DNA is applied for the discovery and engineering of biological pathways, making DNA synthesis a breakthrough of the last century. Thus, the market is anticipated to grow significantly during the forecast period 2022-2032. 

Market Segmentation

Segmentation 1: by Type
•    DNA Phosphoramidites
•    RNA Phosphoramidites
•    Labeled Phosphoramidites
•    Others

Growing research and development activities and demand within the synthetic biology, pharmaceutical, diagnostic, and other industries are increasing the adoption of DNA phosphoramidites. Therefore, the type segment is dominated by DNA phosphoramidites, which held a share of 74.30% in 2021.

Segmentation 2: by End User
•    Pharmaceutical and Biotechnology Companies
•    Diagnostic Laboratories
•    Synthetic Biology and Research Institutes

Among all three segments of end users, the pharmaceutical and biotechnology companies segment accounted for the largest share, holding 47.50% of the market in 2021.

Segmentation 3: by Region
•    North America
•    Europe
•    Asia-Pacific
•    Rest-of-the-World

North America is expected to dominate the global phosphoramidite market during the forecast period 2022-2032.

Recent Developments in the Global Phosphoramidite Market

•    In August 2019, the company acquired 75% ordinary capital of the parent company of Toronto Research Chemicals Inc., i.e., Biomed Pharmaceutical Limited.
•    In July 2022, TriLink BioTechnologies expanded its R&D leadership team's responsibility for leading the company’s scientific direction and research and development strategy.
•    In May 2022, TriLink BioTechnologies announced a cooperative agreement with the Department of Defense and included funding for TriLink’s expansion in San Diego, California, for nucleic acid production.
•    In November 2021, Biosynth Carbosynth acquired Kexing Biopharmaceutical Co., Ltd.’s raw material manufacturing unit located in Jinan, China, to expand its operations and deliver a wide range of products at a larger production volume and increased capacity. The facility extends to more than 30,000 square meters of area.
•    In November 2021, a leading investment firm, KKR, invested an undisclosed amount and acquired Biosynth Carbosynth from its founders, Armira and Dr. Urs Spitz. However, senior management will retain a significant ownership stake, and KKR will contribute as a strategic partner. KKR plans to encourage and accelerate the company's product portfolio expansion and geographic buildout and widen its capabilities.

Demand - Drivers and Limitations

Following are the demand drivers for the global phosphoramidite market:

•    Increasing Synthetic Nucleotide Applications in Therapeutics
•    Growth in Synthetic Biology

The market is expected to face some limitations due to the following challenges:

•    Challenges in Developing Long Nucleotide Sequences
•    Competition from Emerging DNA Synthesis Technologies

Analyst Perspective

According to Sara Virmani, Senior Research Analyst, BIS Research, “Growing research and development activities and demand within the synthetic biology, pharmaceutical, diagnostic, and other industries are increasing the adoption of DNA and RNA-based phosphoramidites. In addition, the increased flow of investments from private and public firms, the emergence of start-ups, and the rising number of partnerships coupled with mergers and acquisitions are fuelling the market growth.”

FAQ's

What is phosphoramidite?

Phosphoramidites are building blocks of oligonucleotide sequences and highly reactive derivatives of nucleosides. They contain prime protecting groups making them the most suitable choice as raw materials compared to others. Typically, the chemistry produces up to 200-300 long oligonucleotide sequences. However, as the synthesized oligonucleotide sequence length grows, its stability and accuracy decrease.

What kinds of new strategies are being adopted by existing market players to strengthen their positions in the industry?

Most companies are focusing on expanding their product portfolios with the launch of best-in-class distinctive novel phosphoramidites and trying to address the limitations and challenges with diversifying phosphoramidites products with efforts to increase their global footprint alongside. According to BIS Research, among the different key developments, business expansions followed by acquisitions constituted the dominant contributor's strategies. The business expansion strategy comprised 63.64% of the total strategies witnessed by the market between January 2019 and August 2022.

For a new company looking to enter the global phosphoramidite market, which areas could it focus upon to stay ahead of the competition?

A new entrant can focus on developing a product high in quality with reduced cost and enhanced customization.

What is the USP of this report?

The following can be seen as some of the USPs of this report:

• Extensive competitive benchmarking of key players offering a holistic view of the global phosphoramidite market landscape 
• Market ranking analysis based on product portfolio, recent developments, and region-level analysis

Who should buy this report?

Established companies involved in the development of phosphoramidite-related products such as oligonucleotides and new entrants who want to focus on the phosphoramidite market would be suitable buyers for this report.

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