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Industry and Technology Overview
Global Multicancer Screening Market Industry Overview
The global multicancer screening market is projected to reach $7.78 billion by 2032 from $1.90 billion in 2022, growing at a CAGR of 15.09% during the forecast period 2023-2032. The growth in the global multicancer screening market is expected to be driven by the increased use of liquid biopsy testing and increasing prevalence of cancers.
Market Lifecycle Stage
Multicancer screening is a cancer screening test that has the potential to screen for more than one cancer type with a single test. This test can be tissue-based or liquid biopsy-based. Most of the newly developed multicancer screening tests in the market right now are liquid biopsy-based, which detects cancer biomarkers in bodily fluids such as blood, saliva, urine, etc. Biomarkers/genetic markers from RNA, DNA, or protein are analyzed from these samples. If any of these biomarkers or gene mutations are positive in the analysis, further follow-up tests need to be performed to confirm the findings.
Some multicancer screening tests can also identify the tissue of the origin of cancer, while others need imaging tests to verify the origin. There are a lot of laboratory-based multicancer screening tests available in the market right now, and a few have also received U.S. Food and Drug Administration (FDA) and conformité européenne (CE) approvals as well. Multicancer screening tests are also important because, according to the America Cancer Society, Inc., 70% of all cancer deaths are from cancers that still do not have any proven individual screening tests. This can be extremely decreased with the advent of new biomarkers through increasing funding investments in multicancer screening tests.
Figure: Global Multicancer Screening Market Snapshot
Source: BIS Research Analysis
Impact
• For instance, in October 2020, Exact Sciences Corporation launched Oncotype MAP Pan-Cancer Tissue test for patients with metastatic, advanced, recurrent, or refractory cancer. The Oncoptype MAP test provides clinically actionable information from hundreds of cancer-related genes that allows physicians to understand the tumor profile of patients and recommend effective clinical trials or targeted therapies.
• In February 2022, GRAIL, LLC. (Illumina, Inc.) collaborated with Point32Health for a two-phased pilot trial of Galleri, which is GRAIL's proprietary multicancer blood test. With this collaboration, Point32Health is the first health plan that would work with GRAIL to complement the recommended cancer screenings.
Impact of COVID-19
In 2019, the world was hit by a pandemic. The culprit is coronavirus disease (COVID-19), which is an illness caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. SARS-CoV-2 was found to be a novel type of coronavirus that started causing severe illness and deaths around the world. The global pandemic began in early 2020, causing mild respiratory tract infections to serious lower respiratory infections. The first case of coronavirus was reported in Wuhan, China, in December 2019.
According to an electronic medical record company, there was approximately an 80%-90% decline in screenings of breast, cervical, and colorectal cancers in patients during March and April of 2020 as compared to the same months in 2019. Even though screenings did increase in June 2020, they were still down by 29%-36%. Additionally, according to the Centers for Disease Control and Prevention, HPV vaccinations dropped by 73% between February and April 2020. The full impact of these delays will be realized in the coming years.
Market Segmentation:
Segmentation 1: by Test Type
• Laboratory Developed Tests (LDTs)
• In-Vitro Diagnostics (IVDs)
The global multicancer screening market (by test type) is expected to be dominated by the laboratory developed tests (LDTs) segment during the forecast period 2023-2032. The in-vitro diagnostics (IVDs) segment is expected to grow with a high CAGR and have a market share of 35.72% till 2032.
Segmentation 2: by Technology
• Next-Generation Sequencing (NGS)
• Polymerase Chain Reaction (PCR)
• Immunohistochemistry (IHC)
• Fluorescence In-Situ Hybridization (FISH)
• Other Technologies
The global multicancer screening market (by technology) is expected to be dominated by the next-generation sequencing (NGS) segment during the forecast period 2023-2032. This is because it is the most efficient and accurate technology currently available when it comes to gene analysis.
Segmentation 3: by Sample
• Tissue
• Blood
• Saliva and Buccal Swab
• Others
The global multicancer screening market (by sample) is expected to be dominated by the tissue segment during the forecast period 2023-2032. This is due to the high validation and trust on these tests as compared to the newer liquid biopsy-based tests.
Segmentation 4: by Method
• DNA
• RNA
• Proteins
The DNA segment is expected to dominate the global multicancer screening market (by method) during the forecast period 2023-2032. This growth in this segment is attributed to the fact that DNA analysis is the most convenient, even with the fast-growing liquid biopsy methods.
Segmentation 5: by Cancer Type
• Breast and Gynecologic
• Gastrointestinal
• Endocrine
• Genitourinary
• Skin
• Brain/Nervous System
• Sarcoma
• Hematological Malignancies
• Lung
• Head and Neck
• Other Cancer Types
The global multicancer screening market (by cancer type) is expected to be dominated by the breast and gynecological segment during the forecast period 2023-2032. This is because the high prevalence of these cancer types and high number of known biomarkers makes them easy to screen for.
Segmentation 6: by Application
• Clinical
• Research
As of 2021, the global multicancer screening market (by application) was dominated by the research segment, holding a 85.06% market share.
Segmentation 7: by End User
• Hospitals
• Diagnostic and Clinical Laboratories
• Academic and Research Institutions
• Other End Users
As of 2021, the global multicancer screening market (by end user) was dominated by the academic and research institutions segment, holding a 62.17% market share.
Segmentation 8: by Region
• North America
• Europe
• Asia-Pacific
• Latin America
• Rest-of-the-World
North America is expected to dominate the global multicancer screening market with a revenue of $0.87 billion in 2021. However, the Asia-Pacific (APAC) region, constituting several emerging economies, is expected to register the highest CAGR of 17.60% during the forecast period 2023-2032.
Recent Developments in Global Multicancer Screening Market
• In March 2021, Agilent Technologies, Inc. made an agreement to acquire Resolution Bioscience Inc. to expand the company's NGS-based cancer diagnostics and its fast-growing precision medicine segment. This agreement was made for $550 million in cash at closing and an additional $145 million when the company achieves future performance milestones.
• In December 2022, Integrated DNA Technologies, Inc. acquired Invitae Corporation.'s next-generation sequencing (NGS) research assays with the Archer trademark for $48 million.
• In January 2023, Laboratory Corporation of America Holdings. acquired Personal Genome Diagnostics for $450 million and for another $125 million as contingent milestone payments. Personal Genome Diagnostics was a next-generation sequencing test maker, and with this acquisition, Laboratory Corporation of America Holdings. has increased its NGS testing portfolio.
• In January 2023, FOUNDATION MEDICINE, INC. (F. Hoffmann-La Roche Ltd) got FDA approval for its FoundationOne Liquid CDx as a companion diagnostic for Rozlytrek. This test is relevant for ROS1+NSCLC patients and NTRK fusion-positive solid tumors patients.
• In January 2023, Burning Rock DX got an FDA Breakthrough Device Designation for its Multi-Cancer Detection Blood Test called OverC. This test is intended for the detection of lung, liver, ovarian, esophageal, and pancreatic cancer for adults aged between 50 and 75 years.
Demand – Drivers and Limitations
Following are the demand drivers for the global multicancer screening market:
• Early Detection of Cancer Leads to Higher Survival Chances and Better Treatment
• Increasing Popularity of Liquid Biopsy Leading to Easier Screening
• Reduced Treatment Cost Due to Earlier Cancer Detection
The market is expected to face some limitations too due to the following challenges:
• Lack of Awareness about the Multicancer Screening Tests
• Too Costly to be Used as Preventive Care
Analyst’s View
According to Swati Sood, Principal Analyst, BIS Research, “Global multicancer screening market is a rapidly emerging market and is expected to revolutionize the field of oncology field in the coming years due to the continuous increase in the demand for cancer diagnosis and industrial analysis.”
Multicancer Screening Market - A Global and Regional Analysis
Focus on Test Type, Technology, Sample, Method, Cancer Type, Application, End User, and Region Analysis - Analysis and Forecast, 2023-2032
Frequently Asked Questions
Multicancer screening is a cancer screening test that has the potential to screen for more than one cancer type with a single test. This test can be tissue-based or liquid biopsy-based. Most of the newly developed multicancer screening tests in the market right now are liquid biopsy-based, which detect cancer biomarkers in bodily fluids such as blood, saliva, urine, etc. Biomarkers/genetic markers from RNA, DNA, or protein are analyzed from these samples. If any of these biomarkers or gene mutations are positive in the analysis, further follow-up tests need to be performed to confirm the findings.
The major advantage of multicancer screening, as compared to individual screening tests, is the ability to screen for multiple tests at the same time. The increasing prevalence of cancer due to the changing lifestyle around the globe calls for a major need for screening tests. Additionally, the advancements in liquid biopsy-based methods and better analysis using technologies like NGS are really increasing the market potential and are expected to revolutionize the oncology field in the coming years.
The global multicancer screening market has seen major developments such as business expansions, partnerships, collaborations, and joint ventures by key players operating in the market. According to BIS Research analysis, the majority of the companies preferred partnerships, collaborations, and joint ventures in addition to multiple product launches as a strategy to further increase their growth in the global multicancer screening market.
A new entrant needs to make sure that the different cancers being tested for are using a validated analytical method, and the discovery of new biomarkers is also an advantage. Additionally, the ability to screen a few rare cancer types can be an advantage. Furthermore, approvals from FDA are still hard to get, and thus all the necessary precautions should be taken to be able to launch it as an LDT as well.
The following can be considered the USPs of the report:
· Vast segmentation of the report, especially the vast number of cancer types considered
· Product specifications and comparative analysis
· Market dynamic analysis of the opportunities, trends, and challenges in the market
· Competitive benchmarking of key players for each product type
· Growth share analysis for key segments
This report will be useful for firms planning to enter the multicancer screening market and investors who want to invest in the product. Additionally, established market players in this market can also benefit from this report. This is because the report discusses the benefits of using multicancer screening tests and the latest advancements in the market right now.